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Ophthalmology General

Association of Cataract Surgery With Risk of Diabetic Retinopathy Among Asian Participants in the Singapore Epidemiology of Eye Diseases Study.

Jun 18, 2020

Cataracts and diabetic retinopathy (DR) are the leading causes of acquired blindness worldwide. Although extraction is the standard treatment option for cataracts, it is also reported to increase the ...

Discordant vascular parameter measurements in diabetic and non-diabetic eyes detected by different optical coherence tomography angiography devices.

Jun 18, 2020

To compare quantitative changes in macular parameters in diabetic patients detected by two optical coherence tomography angiography (OCTA) instruments.80 phakic eyes were classified as no diabetes, di...

Longitudinal Angiographic Evidence that Intraretinal Microvascular Abnormalities Can Evolve into Neovascularization.

Jun 18, 2020

The hallmark of proliferative diabetic retinopathy (PDR) is retinal neovascularization (NV). Tortuous intraretinal vascular segments known as intraretinal microvascular abnormalities (IRMAs) are a kno...

Next generation sequencing using phenotype-based panels for genetic testing in inherited retinal diseases.

Jun 18, 2020

Diagnostic next generation sequencing (NGS) services for patients with inherited retinal diseases (IRD) traditionally use gene panel based approaches, which have cost and resource implications. Phenot...

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).

Jun 18, 2020

To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and...

Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders: From Bench to Bedside.

Jun 15, 2020

Neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD) is a chronic, recurrent, antibody-mediated, inflammatory demyelinating disease of the central nervous system, characterized by optic neuritis a...

Autologous serum eye drops improve tear production, both lachrymal flow and stability tests and conjunctival impression cytology with transfer in dry eye disease.

Jun 15, 2020

Autologous serum eye drops, produced by separation of liquid and cellular components of the patient's blood, contain biological nutrients present in natural tears. The aim of this study was to analyse...

The effect of astaxanthin on inflammation in hyperosmolarity of experimental dry eye model in vitro and in vivo.

Jun 15, 2020

Hyperosmolarity is pro-inflammatory stress to the ocular surface epithelium for dry eye disease (DED). Astaxanthin (AST) is a kind of carotene, which exists in seafood and has been proved to inhibit i...

Blepharospasm, dry eye and extractable nuclear antigen antibodies.

Jun 15, 2020

To study whether there is an association between benign essential blepharospasm and Sjögren's syndrome by analyzing the presence of antibodies to extractable nuclear antigens in this population.Seven...

Destruction of the blood-retina barrier in diabetic retinopathy depends on angiotensin-converting enzyme-mediated TGF-β1/Smad signaling pathway activation.

Jun 15, 2020

Diabetes mellitus (DM) is a systemic, chronic metabolic disease that is related to heredity and autoimmunity and is often accompanied by complications of retinopathy. However, the causative mechanism ...

Artificial intelligence for anterior segment diseases: Emerging applications in ophthalmology.

Jun 15, 2020

With the advancement of computational power, refinement of learning algorithms and architectures, and availability of big data, artificial intelligence (AI) technology, particularly with machine learn...

Omidenepag Isopropyl Versus Latanoprost in Primary Open-angle Glaucoma and Ocular Hypertension: ThePhase 3 AYAME Study.

Jun 15, 2020

To evaluate the efficacy and safety of omidenepag isopropyl (OMDI), a selective, non-prostaglandin, prostanoid EP2 receptor agonist, in Japanese patients with primary open-angle glaucoma (POAG) or ocu...

Differential adaptations in rod outer segment disc membranes in different models of congenital stationary night blindness.

Jun 15, 2020

Rod photoreceptor cells initiate scotopic vision when the light receptor rhodopsin absorbs a photon of light to initiate phototransduction. These photoreceptor cells are exquisitely sensitive and have...

MicroRNA miR-29c-3p modulates FOS expression to repress EMT and cell proliferation while induces apoptosis in TGF-β2-treated lens epithelial cells regulated by lncRNA KCNQ1OT1.

Jun 15, 2020

Age-related cataract (ARC) is a main cause of blindness for elderly people. MicroRNA hsa_miR-29c-3p (miR-29c-3p) was implicated in many biological processes in complicated diseases. However, the biolo...

Association of Weight-Adjusted Caffeine and β-Blocker Use With Ophthalmology Fellow Performance During Simulated Vitreoretinal Microsurgery.

Jun 15, 2020

Vitreoretinal surgery can be technically challenging and is limited by physiologic characteristics of the surgeon. Factors that improve accuracy and precision of the vitreoretinal surgeon are invaluab...

Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones.

Jun 11, 2020

Diffusible small molecule microbial hormones drastically alter the expression profiles of antibiotics and other drugs in actinobacteria. For example, avenolide (a butenolide) regulates production of a...

The effect of oral isotretinoin therapy on meibomian gland morphology and dry eye tests.

Jun 11, 2020

The aim of study was to evaluate the effects of oral isotretinoin on meibomian gland (MG) morphology detected with non-contact meibography and to investigate its relation with clinical dry eye tests....

Fibromyalgia Syndrome and Eye - a review.

Jun 11, 2020

Fibromyalgia is a chronic, widespread pain syndrome, with unclear etiology, characterized by fatigue, sleeping problems, cognitive disorders, somatic complaints and severe pain in tender points of the...

Cataract surgery and dry eye disease: A review.

Jun 11, 2020

To review published literature concerning cataract surgery and dry eye disease (DED).A search was undertaken using the following: PubMed (all years), Web of Science (all years), Ovid MEDLINE(R) (1946 ...

The relationship of central corneal thickness with the status of diabetic retinopathy.

Jun 11, 2020

To compare central corneal thickness (CCT) values measured by three different devices: slit-scanning topography (SST), ultrasonic pachymetry (UP), and optical coherence tomography (OCT) in diabetic ey...

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