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Ophthalmology General

Leber Hereditary Optic Neuropathy: Case Report and Literature Review.

May 28, 2020

Leber hereditary optic neuropathy (LHON) is a genetic condition that typically presents with unilateral, painless, sub-acute central vision loss followed by contralateral vision loss after a few weeks...

Identifying outcomes that are important to patients with ocular hypertension or primary open-angle glaucoma: a qualitative interview study.

May 28, 2020

To explore patients' perspectives and experiences living with glaucoma and identify important benefits and risks that patients consider before electing for new glaucoma treatments, such as minimally i...

Orbital Fat Volume After Treatment with Topical Prostaglandin Agonists.

May 28, 2020

Topical prostaglandin analogs (PGAs) are common treatment for primary open-angle glaucoma (POAG) but reportedly may cause adnexal fat atrophy. We asked if patients with POAG treated with PGAs have abn...

Exergames for balance dysfunction in neurological disability: a meta-analysis with meta-regression.

May 26, 2020

To evaluate systematically the efficacy of exergames for balance dysfunction in neurological conditions and to identify factors of exergaming protocols that may influence their effects.We searched ele...

Risk factors associated with severity of dry eye syndrome in ocular graft-versus-host disease.

May 26, 2020

The aim of this study was to identify risk factors for the development of severe dry eye syndrome (DES) in patients with ocular graft-versus-host disease (oGVHD).Retrospective Chart Review.Patients un...

Next-Generation Sequencing of the Ocular Surface Microbiome: In Health, Contact Lens Wear, Diabetes, Trachoma, and Dry Eye.

May 26, 2020

To assess publications examining the occurrence, composition, and clinical significance of a microbiome at the ocular surface.MEDLINE, EMBASE, and Google Scholar were searched. Reference lists of incl...

Simplified Classification of Tear Film Break-Up Patterns and Their Clinicopathological Correlations in Patients With Dry Eye Disease.

May 26, 2020

To analyze the pathophysiological differences between patients with dry eye disease (DED) having different tear film break-up patterns (TBUPs).This investigative analysis involved 91 eyes of 91 patien...

Inflammation and oxidative stress induced by lipid peroxidation metabolite 4-hydroxynonenal in human corneal epithelial cells.

May 26, 2020

Oxidative stress is widely known to be a major contributor in the pathogenesis of dry eye disease (DED). 4-Hydroxynonenal (4-HNE), a well-known byproduct frequently measured as an indicator of oxidati...

The Human Lacrimal Gland: Historical Perspectives, Current Understanding and Recent Advances.

May 26, 2020

The lacrimal glands produce the aqueous component of the pre-ocular tear film, which is essential for ocular health and optimal vision. This review explores its history, current understanding and rece...

Preclinical challenges for developing long acting intravitreal medicines.

May 26, 2020

The majority of blinding conditions arise due to chronic pathologies in the retina. During the last two decades, antibody-based medicines administered by intravitreal injection directly into the back ...

Quantitative assessment of the severity of diabetic retinopathy.

May 26, 2020

To determine whether a quantitative approach to assessment of the severity of diabetic retinopathy (DR) lesions on ultrawide field (UWF) images can provide new parameters to predict progression to pro...

Extended Zone Retinal Vascular Caliber and Risk of Diabetic Retinopathy in Adolescents with Type 1 Diabetes.

May 26, 2020

Retinal vascular caliber has been linked to diabetic retinopathy (DR). Newer imaging technologies allow analysis of retinal vascular caliber beyond the standard areas surrounding the optic disc. We in...

Association of alcohol intake with incidence and progression of diabetic retinopathy.

May 26, 2020

We examined the longitudinal association of baseline alcohol intake and frequency with the 6-year incidence and progression of diabetic retinopathy (DR) in a population-based cohort of Singaporean Ind...

Long non-coding RNA VIM Antisense RNA 1 (VIM-AS1) sponges microRNA-29 to participate in diabetic retinopathy.

May 26, 2020

Long non-coding RNA (lncRNA) VIM Antisense RNA 1 (VIM-AS1) has been reported to be correlated with type 2 diabetes (T2D) susceptibility, while the roles of this lncRNA in T2D and its complications rem...

Prevalence of Visual Impairment and Coverage of Cataract Surgical Services: Associations with Sex, Disability, and Economic Status in Five Diverse Sites.

May 26, 2020

Prevalence of visual impairment (VI) and access to services can vary significantly across and between different population groups. With renewed focus on universal health coverage and leaving no one be...

Eye Care Utilization in A Community-oriented Mobile Screening Programme for Improving Eye Health in Iran: A Cluster Randomized Trial.

May 26, 2020

To evaluate the effect of a mobile-based screening programme on eye care utilization in Iran.In this cluster randomized community trial, a representative sample of residents aged≥50 years from urba...

Rates of Glaucomatous Structural and Functional Change from a Large Clinical Population: The Duke Glaucoma Registry Study.

May 26, 2020

To investigate rates of structural and functional change in a large clinical population of glaucoma and glaucoma suspect patients.Retrospective cohort.29,548 spectral-domain optical coherence tomograp...

Learning from the past: Mitomycin C use in trabeculectomy and its application to bleb-forming minimally invasive glaucoma surgery.

May 26, 2020

Trabeculectomy has been performed since the mid-1960s and remains the gold standard for glaucoma surgery. Newer surgical options have evolved, collectively referred to as minimally invasive glaucoma s...

Functional Annotations of Single-Nucleotide Polymorphism (SNP)-Based and Gene-Based Genome-Wide Association Studies Show Genes Affecting Keratitis Susceptibility.

May 26, 2020

BACKGROUND Keratitis is a complex condition in humans and is the second most common cause of legal blindness worldwide. MATERIAL AND METHODS To reveal the genomic loci underlying keratitis, we perform...

Atypical Horner's syndrome: frequency, features and aetiology in a paediatric population.

May 26, 2020

Paediatric Horner's syndrome (HS) may present atypically with incomplete or intermittent clinical features, yet could represent sinister pathology including neuroblastoma. We aim to report the frequen...

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