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Ophthalmology General

Hypomethylation of Notch1 DNA is Associated with the Occurrence of Uveitis.

Jun 04, 2020

Uveitis is a serious intraocular inflammatory disease that can lead to visual impairment even blindness worldwide. Notch signaling can regulate the differentiation of naïve CD4 T cells, influencing t...

Determination of Tear Lipid Film Thickness Based on a Reflected Placido Disk Tear Film Analyzer.

Jun 04, 2020

This study aims at determining the thickness of the tear lipid layer (LL) observed from a placido-disc-based tear film analyzer. We prospectively collected reflections of placido-disk LL images using ...

Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye.

Jun 04, 2020

The ocular drug discovery field has evidenced significant advancement in the past decade. The FDA approvals of Rhopressa, Vyzulta, and Roclatan for glaucoma, Brolucizumab for wet age-related macular d...

A Multi-Center Study of the Prevalence of Dry Eye Disease in Chinese Refractive Surgery Candidates.

Jun 04, 2020

To determine the prevalence of preoperative dry eye disease and evaluate tear film function in refractive surgery candidates in China.In this prospective noninterventional cross-sectional study, refra...

Tilianin Protects Diabetic Retina through the Modulation of Nrf2/TXNIP/NLRP3 Inflammasome Pathways.

Jun 04, 2020

Oxidative stress and inflammation are regarded as prime reasons for the progression and development of diabetic retinopathy. Currently, nuclear factor erythroid-2-related factor 2 (Nrf2), thioredoxin ...

Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes.

Jun 04, 2020

Mitochondrial damage in the cells comprising inner (retinal endothelial cells) and outer (retinal pigment epithelium (RPE)) blood-retinal barriers (BRB) is known to precede the initial BRB breakdown a...

Comprehensive genomic diagnosis of inherited retinal and optical nerve disorders reveals hidden syndromes and personalized therapeutic options.

Jun 04, 2020

In the era of precision medicine, genomic characterization of blind patients is critical. Here, we evaluate the effects of comprehensive genetic analysis on the etiologic diagnosis of potentially here...

Structural assessment of the optic nerve in patients with obstructive sleep apnea syndrome: Case-control study.

Jun 04, 2020

Obstructive sleep apnea syndrome has been identified as a possible risk factor for optic nerve pathology such as glaucoma, nonarteritic ischemic optic neuropathy, and optic disk edema. Accordingly, we...

A pilot study to evaluate the levels of aqueous humor trace elements in open-angle glaucoma.

Jun 04, 2020

Primary open angle glaucoma (POAG) is the most common form of chronic, progressive optic neuropathies characterized by slow degeneration of the retinal ganglion cells and their axons, resulting in vis...

The role of Th17 immunity in chronic ocular surface disorders.

Jun 01, 2020

Th17 cells have been implicated in the pathogenesis of numerous inflammatory and autoimmune conditions. At the ocular surface, Th17 cells have been identified as key effector cells in chronic ocul...

Evaluation of ocular surface disease in elderly patients with glaucoma: expression of matrix metalloproteinase-9 in tears.

Jun 01, 2020

To evaluate the symptoms and signs of ocular surface disease (OSD) and tear-film matrix metalloproteinase-9 (MMP-9) overexpression using point-of-care testing (InflammaDry test) in patients with prima...

Dry Eye and Quantitative and Qualitative Changes of Meibomian Glands in Patients With Pemphigus.

Jun 01, 2020

To evaluate dry eye and quantitative and qualitative changes of meibomian glands with meibography in patients with pemphigus.Twenty left eyes of 20 patients with pemphigus (group 1) and 20 left eyes o...

Efficacy of conbercept combined with panretinal photocoagulation in the treatment of proliferative diabetic retinopathy.

Jun 01, 2020

This prospective clinical study was to compare the effect of panretinal photocoagulation (PRP) associated with intravitreal conbercept injections versus PRP alone in the treatment of proliferative dia...

Intravitreal ranibizumab alone or in combination with panretinal photocoagulation for the treatment of proliferative diabetic retinopathy with coexistent macular edema: long-term outcomes of a prospective study.

Jun 01, 2020

To compare intravitreal ranibizumab as monotherapy or in combination with panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR) and coexistent diabetic macular ed...

Dichloroacetate prevents TGFβ-induced epithelial-mesenchymal transition of retinal pigment epithelial cells.

Jun 01, 2020

Proliferative retinopathies are associated with formation of fibrous epiretinal membranes. At present, there is no pharmacological intervention for the treatment of retinopathies. Cytokines such as TG...

Le Fort III Distraction Osteogenesis Without Bicoronal Incision.

Jun 01, 2020

Recently, midfacial hypoplasia for syndromic craniosynostosi has been corrected by Le Fort III distraction osteogenesis. During conventional Le Fort III osteotomy, osteotomy is performed via bicoronal...

No olfactory compensation in food-related hazard detection among blind and deaf adults: a psychophysical approach.

Jun 01, 2020

The exposure-driven olfactory compensation associated with sensory loss is likely to be observed in assessment of food-related dangers. Therefore, in the current study we tested the hypothesis that ol...

Causes of vision loss at China's largest blind school during a period of significant economic growth: 2008-2016.

Jun 01, 2020

To investigate the different causes of vision loss and school-based treatment regimens at Quanzhou Blind School (QBS), China's largest blind school, in 2008 and 2016.In 2008, 144 students received com...

Successful cataract surgery leads to an improvement of depressive symptomatology.

May 28, 2020

Introduction Cataract is the most common reversible cause of blindness worldwide and the associated vision impairment has been associated with an adverse impact on health-related quality of life and m...

The Efficacy of Intense Pulsed Light Combined With Meibomian Gland Expression for the Treatment of Dry Eye Disease Due to Meibomian Gland Dysfunction: A Multicenter, Randomized Controlled Trial.

May 28, 2020

To compare the efficacy of intense pulsed light (IPL) combined with Meibomian gland expression (MGX), and instant warm compresses combined with MGX, for treatment of dry eye disease (DED) due to meibo...

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