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Ophthalmology General

Central nervous signs, blindness and cerebral vermicosis in free-ranging peregrine falcons (Falco peregrinus) associated with aberrant larval migrations.

May 26, 2020

Four free-ranging peregrine falcons (Falco peregrinus) were submitted with a history of unilateral or bilateral blindness and central nervous signs to a veterinary clinic in Germany. There were no ind...

Efficacy of adjunctive therapy using Vizoovet in improving clinical signs of keratoconjunctivitis sicca in dogs: A pilot study.

May 12, 2020

To assess the clinical safety and efficacy of adjunctive therapy using Vizoovet to ameliorate clinical signs of keratoconjunctivitis sicca (KCS) in dogs.Twenty client-owned dogs.Canine patients diagno...

Pigment Epithelium-derived factor secreted by corneal epithelial cells regulates dendritic cell maturation in dry eye disease.

May 12, 2020

In this study, we quantify Pigment Epithelium-derived Factor (PEDF) secreted by corneal epithelial cells and its immunomodulatory functions in a murine model of dry eye disease (DED).We induced DED in...

Dry anophthalmic socket syndrome - Standardized clinical evaluation of symptoms and signs.

May 12, 2020

To assess symptoms and signs of the dry anophthalmic socket syndrome (DASS) in a standardized manner.87 unilateral anophthalmic patients were evaluated using the Ocular Surface Disease Index (OSDI), t...

When rheumatoid arthritis is mentioned, should only dryness come to mind?

May 12, 2020

To evaluate corneal parameters of rheumatoid arthritis (RA) patients by corneal topography.One hundred two RA patients and 60 control subjects were enrolled. Corneal topography measurements and ophtha...

Loteprednol Etabonate for the Treatment of Dry Eye Disease: A Literature Review.

May 12, 2020

Dry eye disease (DED) is a common ocular condition that can impair vision and may adversely impact quality of life. Due to the inflammatory nature of this disorder, topical corticosteroids are an effe...

Diabetic retinopathy in well-controlled type 2 diabetes: role of glycaemic memory.

May 12, 2020

As diabetic retinopathy (DR) can occur even in well-controlled patients with type 2 diabetes (T2D), our study sought to determine whether it might be related to 'glucose memory 'by evaluating patients...

Correlation of Quantitative Measurements with Diabetic Disease Severity Utilizing Multiple En-Face OCTA Image Averaging.

May 12, 2020

To evaluate the effect of averaging en-face optical coherence tomography angiography (OCTA) images on quantitative measurements of the retinal microvasculature and their correlation to diabetic retino...

Matrix Metalloproteases and Cathepsin D in Human Serum do not Cleave Prolactin to Generate Vasoinhibin.

May 12, 2020

Vasoinhibin is generated in the pituitary gland and in multiple target tissues by proteolytic cleavage of prolactin by matrix metalloproteinases and cathepsin D. A dysregulation of vasoinhibin generat...

Evaluating Signs of Microangiopathy Secondary to Diabetes in Different Areas of the Retina with Swept Source OCTA.

May 12, 2020

The purpose of this study was to compare perfusion parameters of the parafovea with scans outside the parafovea to find an area most susceptible to changes secondary to diabetic retinopathy (DR).Patie...

Vascular changes precede tomographic changes in diabetic eyes without retinopathy and improve artificial intelligence diagnostics.

May 12, 2020

The purpose of this study was to evaluate early vascular and tomographic changes in the retina of diabetic patients using artificial intelligence (AI). The study included 74 age-matched normal eyes, 1...

Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism.

May 12, 2020

FGF8-FGFR1 signalling is involved in multiple biological processes, while impairment of this signalling is one of the main reasons for isolated hypogonadotropic hypogonadism (IHH). Recently, several n...

Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma.

May 12, 2020

Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of blindness worldwide. As an o...

Expression of mRNAs, miRNAs, and lncRNAs in Human Trabecular Meshwork Cells Upon Mechanical Stretch.

May 12, 2020

Intraocular pressure (IOP), the primary risk factor for primary open-angle glaucoma, is determined by resistance to aqueous outflow through the trabecular meshwork (TM). IOP homeostasis relies on TM r...

Comparison of Lamina Cribrosa Morphology in Normal Tension Glaucoma and Autosomal-Dominant Optic Atrophy.

May 12, 2020

To compare lamina cribrosa (LC) morphology in patients with normal tension glaucoma (NTG) and autosomal-dominant optic atrophy (ADOA).This cross-sectional study matched 24 patients diagnosed with ADOA...

Review of Longitudinal Glaucoma Progression: 5 Years after the Shaffer Lecture.

May 12, 2020

In 2013, the senior author delivered the American Academy of Ophthalmology Robert N. Shaffer Lecture entitled "Glaucoma Changes-Reality Bites." This talk focused on describing the longitudinal structu...

Disease Course in Siblings With Stargardt Disease

May 08, 2020

Stargardt disease (STGD1) is an autosomal recessively inherited retinal disease (IRD) caused by variants in the ABCA4 gene, and it is characterized by degeneration of the central retina, leading to de...

Prediction of vestibular schwannoma recurrence using artificial neural network.

Apr 28, 2020

To compare two statistical models, namely logistic regression and artificial neural network (ANN), in prediction of vestibular schwannoma (VS) recurrence.Seven hundred eighty-nine patients with VS dia...

microRNA-216a protects against human retinal microvascular endothelial cell injury in diabetic retinopathy by suppressing the NOS2/JAK/STAT axis.

Apr 28, 2020

Since microRNAs (miRNAs) represent as effective therapeutic targets for diabetic retinopathy (DR), we identified aberrantly expressed miRNAs related to cellular dysfunction in DR and further detected ...

Neurodegeneration in systemic lupus erythematosus: layer by layer retinal study using optical coherence tomography.

Apr 28, 2020

Systemic lupus erythematosus (SLE) is a chronic, autoimmune and multisystemic disease. Recent studies with functional and structural magnetic resonance imaging and cognitive tests report an unexpected...

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