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Ophthalmology General

Designing and Validating a Low-Cost Real Time Locating System to Continuously Assess Patient Wait Times.

Apr 28, 2020

Outpatient clinics lack infrastructure to easily measure and understand patient wait times. Our objective was to design a low-cost, portable passive real time locating system within an outpatient clin...

Accuracy of Autorefraction in Children: A Report by the American Academy of Ophthalmology.

Apr 28, 2020

The purpose of this assessment is to evaluate the accuracy of autorefraction compared with cycloplegic retinoscopy in children.Literature searches were last conducted in October 2019 in the PubMed and...

Intense Pulsed Light for Meibomian Gland Disease: A Report by the American Academy of Ophthalmology.

Apr 28, 2020

To review the literature on the efficacy of intense pulsed light (IPL) on the eyelids in the management of meibomian gland disease (MGD) and meibomian gland-related ocular surface disease.A literature...

SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration.

Apr 22, 2020

Retinal degeneration is the leading cause of incurable blindness worldwide and is characterised by progressive loss of light-sensing photoreceptors in the neural retina. SARM1 is known for its role in...

Clinical Accuracy of an Advanced Corneal Topographer with Tear-Film Analysis in Functional and Structural Evaluation of Dry Eye Disease.

Apr 22, 2020

: Dry eye disease (DED) is a common condition that significantly lowers the quality of life. As the disease grows more prevalent, multiple commercial instruments have been developed to measure the ocu...

Amniotic membrane transplantation for managing dry eye and neurotrophic keratitis.

Apr 22, 2020

Neurotrophic keratitis (NK), a degenerative disease caused by damage to the trigeminal nerve, abolishes both tearing and blinking reflexes, thus causing the most severe forms of dry eye disease (DED)....

Efficacy and safety of 0.0015% tafluprost versus 0.005% latanoprost in primary open angle glaucoma, ocular hypertension: a Meta-analysis.

Apr 22, 2020

To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of tafluprost 0.0015% eye drops [benzalkonium chloride (BAK) 0.1 mg/mL] compared with that of latanoprost 0.005% eye drops (BAK ...

Systemic risk factors of dry eye disease subtypes: A New Zealand cross-sectional study.

Apr 22, 2020

To evaluate systemic risk factors of dry eye disease, aqueous tear deficiency, and meibomian gland dysfunction.Three hundred and seventy-two community residents (222 females, 150 males; mean ± SD...

Aberrant HLA-DR expression in the conjunctival epithelium after autologous serum treatment in patients with graft-versus-host disease or Sjögren's syndrome.

Apr 22, 2020

The aim of this study was to determine the effect of autologous serum (AS) eye drops on the density of human leucocyte antigen (HLA)-DR-positive epithelial cells and Langerhans cells on the ocular sur...

Concentrations of Selected Cytokines and Vascular Endothelial Growth Factor in Aqueous Humor and Serum of Diabetic Patients.

Apr 22, 2020

: To investigate the aqueous humor and serum levels of selected cytokines and vascular endothelial growth factor (VEGF) in diabetic patients, implicating their role in the pathogenesis of diabetic eye...

Vasant Kusmakar Ras, an ayurvedic herbo-mineral formulation prevents the development of diabetic retinopathy in rats.

Apr 22, 2020

Diabetic retinopathy is a slow progressing complication of diabetes mellitus with multifactorial aetiology affecting approximately 80% of diabetics worldwide. Chronic hyperglycemic milieu of Diabetes ...

Epigenetics and Mitochondrial Stability in the Metabolic Memory Phenomenon Associated with Continued Progression of Diabetic Retinopathy.

Apr 22, 2020

Retinopathy continues to progress even when diabetic patients try to control their blood sugar, but the molecular mechanism of this 'metabolic memory' phenomenon remains elusive. Retinal mitochondria ...

Different fundus imaging modalities and technical factors in AI screening for diabetic retinopathy: a review.

Apr 22, 2020

Effective screening is a desirable method for the early detection and successful treatment for diabetic retinopathy, and fundus photography is currently the dominant medium for retinal imaging due to ...

Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells.

Apr 22, 2020

Impairment of mitochondrial structure and function is strongly linked to glaucoma pathogenesis. Despite the widely appreciated disease relevance of mitochondrial dysfunction and loss, the molecular me...

Using an integrative machine learning approach utilising homology modelling to clinically interpret genetic variants: CACNA1F as an exemplar.

Apr 22, 2020

Advances in DNA sequencing technologies have revolutionised rare disease diagnostics and have led to a dramatic increase in the volume of available genomic data. A key challenge that needs to be overc...

Questionnaire survey on complications during 24-h measurement of intraocular pressure-related patterns with a contact lens sensor.

Apr 22, 2020

We investigated glaucoma patients' complications, subjective symptoms, and side effects of continuous 24-h measurement of intraocular pressure (IOP)-related patterns with a contact lens sensor (CLS). ...

Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane.

Apr 22, 2020

Corneal trauma and ulcerations are leading causes of corneal blindness around the world. These lesions require attentive medical monitoring since improper healing or infection has serious consequences...

Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head.

Apr 22, 2020

To study the effect of changing heart rate on the ocular pulse and the dynamic biomechanical behavior of the optic nerve head (ONH) using a comprehensive mathematical model.In a finite element model o...

Recent trends in vision impairment certifications in England and Wales.

Apr 22, 2020

The Certificate of Visual Impairment (CVI) provides essential data for preventable sight loss indicators as part of the Public Health Outcomes Framework (PHOF) published annually by the Department of ...

Outcomes and Complications Associated with Noninfectious Uveitis in Patients Presenting with Rhegmatogenous Retinal Detachment.

Apr 22, 2020

To evaluate the visual outcomes and complications associated with noninfectious uveitis in patients presenting with a rhegmatogenous retinal detachment (RRD).Retrospective cohort study.A total of 554 ...

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