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Ophthalmology General

Vision-Related Quality of Life among Adult Patients with Visual Impairment at University of Gondar, Northwest Ethiopia.

Apr 14, 2020

The purpose of this study was to assess vision-related quality of life and associated factors among adult patients with visual impairment at the University of Gondar Tertiary Eye Care and Training Cen...

Genetic characterization and long-term management of severely affected siblings with intellectual developmental disorder with cardiac arrhythmia syndrome.

Apr 14, 2020

We report two brothers with severe global cognitive and motor delay, cortical visual impairment and sick sinus syndrome who were born to consanguineous parents. Standard genetic evaluations did not re...

[Comprehensive Assessment and Treatment of Cataracts].

Apr 14, 2020

Cataract is a global disease that may cause blindness. Due to the slow pace of disease progression, patients often presume incorrectly that their blurred vision is caused by excessive fatigue or lack ...

Latanoprost niosomes as a sustained release ocular delivery system for the management of glaucoma.

Apr 14, 2020

Glaucoma is a leading cause of irreversible blindness worldwide. Whereas latanoprost is one of the most effective drugs in glaucoma treatment, its eye drops need frequent application leading to lack ...

Physician Satisfaction with Anti-Inflammatory Topical Medications for the Treatment of Dry Eye Disease.

Apr 14, 2020

Dry eye disease (DED) is one of the most common ophthalmic disorders. Pathogenesis of the disease includes inflammation of the ocular surface and lacrimal gland. Two anti-inflammatory prescription tre...

The Lacritin-Syndecan-1-Heparanase Axis in Dry Eye Disease.

Apr 14, 2020

Homeostasis and visual acuity of the surface of the eye are dependent on tears, a thin film comprising at least 1800 different extracellular proteins and numerous species of lipids through which 80% o...

Patient-Reported Burden of Dry Eye Disease in the United States: Results of an Online Cross-Sectional Survey.

Apr 14, 2020

To evaluate functional vision, general health status, and work productivity in individuals with and without dry eye disease (DED).Cross-sectional study.SettingGeneral US population (2018).Adults ≥18...

Effect of Diquafosol Ophthalmic Solution on Airflow-Induced Ocular Surface Disorder in Diabetic Rats.

Apr 14, 2020

To examine the effect of 3% diquafosol ophthalmic solution (DQS) on ocular surface disorders in diabetic model rats maintained in a continuous airflow condition.Goto-Kakizaki (GK) rats, a spontaneous ...

A Retrospective Study of Treatment Outcomes and Prognostic Factors of Intense Pulsed Light Therapy Combined With Meibomian Gland Expression in Patients With Meibomian Gland Dysfunction.

Apr 14, 2020

To evaluate clinical changes after intense pulsed light and meibomian gland expression (IPL/MGX) treatment in meibomian gland dysfunction (MGD) patients, and to identify ideal candidates, and the ther...

Leu124Serfs*26, a novel mutation in congenital generalized lipodystrophy with early cardiovascular complications.

Apr 14, 2020

Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by the near-total loss of subcutaneous adipose tissue soon after birth, resulting in ectopic fat deposit...

Impact of Carotid Endarterectomy on Choroidal Thickness and Volume in Enhanced Depth Optical Coherence Tomography Imaging.

Apr 14, 2020

Carotid endarterectomy (CEA) is considered an effective therapeutic method for improving ocular circulation. The choroid is a predominantly vascular tissue; thus, systemic and local vascular alteratio...

Association between diabetic retinopathy and interleukin-related gene polymorphisms: A machine learning aided meta-analysis.

Apr 14, 2020

: Diabetic retinopathy (DR) is a severe complication of diabetes and a common cause of visual loss in adults. We aimed to assess the correlation between IL gene-related SNPs and the incidence of DR an...

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography.

Apr 14, 2020

The vascular supply to the retina has been shown to dynamically adapt through vasoconstriction and vasodilation to accommodate the metabolic demands of the retina. This process, referred to as retinal...

Early prevention of diabetes microvascular complications in people with hyperglycaemia in Europe. ePREDICE randomized trial. Study protocol, recruitment and selected baseline data.

Apr 14, 2020

To assess the effects of early management of hyperglycaemia with antidiabetic drugs plus lifestyle intervention compared with lifestyle alone, on microvascular function in adults with pre-diabetes.Tri...

Is it Usher syndrome? Collaborative diagnosis and molecular genetics of patients with visual impairment and hearing loss.

Apr 14, 2020

: Usher syndrome is the most common hereditary syndrome combining deafness and blindness. In the 2017 National Child Count of Children and Youth who are Deaf-Blind, Usher syndrome represented 329 of 1...

Evaluation of the association between five genetic variants and primary open-angle glaucoma in a Han Chinese population.

Apr 14, 2020

: A large genome-wide association study showed that five new variants, { (rs3816415), (rs1258267), (rs736893), (rs7494379), and (rs3739821)}, were associated primary angle-closure glaucoma (PACG)....

Association of High-Mobility Group Box-1 with Inflammation-Related Cytokines in the Aqueous Humor with Acute Primary Angle-Closure eyes.

Apr 14, 2020

Aiming at measuring levels of High-mobility group box-1 (HMGB1) and inflammation-related cytokines in the aqueous humor of patients with acute primary angle-closure glaucoma (APAG) and age-related cat...

Ginkgo Biloba Extract in Ophthalmic and Systemic Disease, With a Focus on Normal-Tension Glaucoma.

Apr 14, 2020

Glaucoma is a neurodegenerative eye disease that results in retinal ganglion cell loss and ultimately loss of vision. Elevated intraocular pressure (IOP) is the most common known risk factor for retin...

Comparison of Rate of change between Bruch's Membrane Opening-Minimum Rim Width and RNFL in Eyes showing Optic Disc Hemorrhage.

Apr 14, 2020

To investigate and compare the longitudinal rate of change of Bruch's membrane opening-minimum rim width(BMO-MRW) and peripapillary retinal nerve fiber layer(RNFL) thickness in eyes showing optic-disc...

Endogenous Endophthalmitis: yield of the diagnostic evaluation.

Apr 14, 2020

Endogenous endophthalmitis is an infection of the eye secondary to sepsis, occurring in 0.04-0.5% of bacteremia or fungemia. Risk factors include intravenous drug abuse (IVDA), diabetes, indwelling ca...

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