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Ophthalmology General

Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial.

Mar 23, 2020

Pharmacological prevention against relapses in patients with neuromyelitis optica spectrum disorder (NMOSD) is developing rapidly. We aimed to investigate the safety and efficacy of rituximab, an anti...

The role of TLR4/NF-κB signaling pathway in activated microglia of rats with chronic high intraocular pressure and vitro scratch injury-induced microglia.

Mar 23, 2020

Glaucoma is a kind of blind-causing disease with structural damages of optic nerve and defection of visual field. It is believed that the death of retinal ganglion cell (RGC) is a consequential event ...

Disease mechanisms and gene therapy for Usher syndrome.

Mar 23, 2020

Usher syndrome (USH) is a major cause of deaf-blindness in humans, affecting ∼400 000 patients worldwide. Three clinical subtypes, USH1-3, have been defined, with 10 USH genes identified so far. In...

Crossmodal reorganisation in deafness: mechanisms for functional preservation and functional change.

Mar 23, 2020

The study of deafness and blindness has contributed unique knowledge to our understanding of the brain, showing that environmental experience critically shapes neural structure and function. Neverthel...

Advances in the Evaluation and Management of Cortical/Cerebral Visual Impairment in Children.

Mar 23, 2020

Cortical/cerebral visual impairment (CVI) is the most frequent cause of pediatric visual impairment in developed countries and is increasing in prevalence in developing nations. The most common underl...

Unilateral Orbital Emphysema Secondary to Vitreoretinal Surgery.

Mar 23, 2020

To describe preoperative, intraoperative, and postoperative characteristics, imaging findings, and clinical evolution of patients who developed orbital emphysema after vitreoretinal surgery.Retrospect...

Features of cotton wool spots in diabetic retinopathy: a spectral-domain optical coherence tomography angiography study.

Mar 23, 2020

To describe the features of cotton wool spots (CWSs) in diabetic retinopathy (DR) by using spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCT angio...

Mortality and causes of death in a population with blindness in Korea: A longitudinal follow-up study using a national sample cohort.

Mar 19, 2020

The influence of visual impairment and blindness on the risk of mortality has been reported in diverse cohort studies. However, the results reported have varied from nonsignificant to significant asso...

Managing intravascular complications following treatment with calcium hydroxylapatite: An expert consensus.

Mar 19, 2020

Inadvertent intra-arterial injection of dermal fillers including calcium hydroxylapatite (CaHA) can result in serious adverse events including soft tissue necrosis, permanent scarring, visual impairme...

Correlation of Non-invasive Tear Break-Up Time with Tear Osmolarity and Other Invasive Tear Function Tests.

Mar 19, 2020

: To compare the outcomes of non-invasive break-up time (NI-BUT) test and the other conventional dry eye tests.: The right eyes of 170 subjects were included in the study. In order to evaluate the tea...

Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction.

Mar 19, 2020

Meibomian gland dysfunction (MGD) is the major cause of evaporative dry eye disease, which is the more prevalent form of dry eye disease. Intense pulsed light (IPL) therapy, involving treatment of the...

New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study.

Mar 19, 2020

To evaluate the effects of a new lubricating, antioxidant solution (VisuEvo) on dry eye disease (DED) in patients undergoing cataract surgery.Patients requiring cataract surgery with either healthy oc...

Thinning of Macular Neuroretinal Layers Contributes to Sleep Disorder in Patients With Type 2 Diabetes Without Clinical Evidences of Neuropathy and Retinopathy.

Mar 19, 2020

To investigate the impact of thinning at individual grids of macular neuroretinal layers, clinical factors, and inadequate light exposure on the specific components of sleep disorder in patients with...

Choroidal Thickness and Urinary Albumin Excretion in Type 2 Diabetic Patients without Retinopathy.

Mar 19, 2020

The role of retinal vasculature's dysfunction in the physiopathology of Diabetic Retinopathy (DR) has been extensively described. Recently, the existence of a diabetic choroidal vasculopathy has been ...

Effect of Astragalus polysaccharide in treatment of diabetes mellitus: a narrative review.

Mar 19, 2020

Diabetes mellitus is a chronic endocrine/metabolism disease characterized by hyperglycemia arising from defects in insulin action, insulin secretion, or both. Diabetes mellitus is often complicated by...

Effects of Huangban Bianxing One decoction combined with ranibizumab on treating exudative age-related macular degeneration.

Mar 19, 2020

To evaluate the clinical efficacy and safety of Chinese medicine formula Huangban Bianxing One decoction (HBOD) combined with ranibizumab for treating exudative age-related macular degeneration (AMD) ...

Gait and Balance as Predictors and/or Mediators of Falls in Glaucoma.

Mar 19, 2020

To investigate the association between balance and gait measures with fall rates in glaucoma patients.Balance and gait were measured for 239 participants with glaucoma or suspected glaucoma. Daily fal...

The vitamin B12 processing enzyme, mmachc, is essential for zebrafish survival, growth and retinal morphology.

Mar 19, 2020

Cobalamin C deficiency (cblC), the most common inborn error of intracellular cobalamin metabolism, is caused by mutations in MMACHC, a gene responsible for the processing and intracellular trafficking...

Intravitreal Conbercept Injection as an Adjuvant in Vitrectomy with Silicone Oil Infusion for Severe Proliferative Diabetic Retinopathy.

Mar 19, 2020

To assess the clinical effects of preoperative, intraoperative, or preoperative combined with intraoperative intravitreal conbercept (IVC) injection in vitrectomy with silicone oil tamponade for seve...

The relative influence of intellectual disabilities and autism on sensory impairments and physical disability: A whole-country cohort of 5.3 million children and adults.

Mar 19, 2020

Intellectual disabilities and autism are lifelong and often co-occur. Little is known on their extent of independent association with sensory impairments and physical disability.For Scotland's populat...

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