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Ophthalmology General

Identification of Novel Mutations in the and Genes in Patients with Familial Exudative Vitreoretinopathy in South India.

Jan 31, 2020

Familial exudative vitreoretinopathy (FEVR) is an inheritable retinal vascular disease, which often leads to severe vision loss and blindness in children. However, reported mutations can only account...

A sensitive period in the neural phenotype of language in blind individuals.

Jan 31, 2020

Congenital blindness modifies the neural basis of language: "visual" cortices respond to linguistic information, and fronto-temporal language networks are less left-lateralized. We tested the hypothes...

Design and baseline data of a population-based metabonomics study of eye diseases in eastern China: the Yueqing Ocular Diseases Investigation.

Jan 30, 2020

China is undergoing a massive transition toward an urban and industrial economy. These changes will restructure the demographics and economy which will eventually influence the future patterns of dis...

Survival and ocular preservation in a long-term cohort of Japanese patients with retinoblastoma.

Jan 30, 2020

Retinoblastoma is an ocular tumor in infants with cancer predisposition. Treatment of the rare tumor needs to be optimized for ocular preserved survival without second primary malignancy (SPM).We stud...

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits.

Jan 30, 2020

Dry eye disease (DED) is a complex disease with multiple etiologies and variable symptoms, having ocular surface inflammation as its key pathophysiologic step. Despite advances in our understanding of...

The Role of Fish Oil in Inflammatory Eye Diseases

Jan 30, 2020

Consumption of fish oil is associated with reduced morbidity and mortality of cardiovascular diseases and also reduces the severity of many other inflammatory diseases and autoimmune disorders. The be...

Ocular Involvement in Systemic Lupus Erythematosus Patients

Jan 30, 2020

To evaluate ocular involvement in a cohort of systemic lupus erythematosus (SLE) patients of a tertiary referral center and to compare the results with the existing literature.Patients underwent a com...

HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease.

Jan 30, 2020

The purpose of this study was to investigate the expression of death ligands in the lacrimal glands (LGs), identify upstream factors that regulate their expression, and determine the functional roles ...

Effects of Switching to Aflibercept in Treatment Resistant Macular Edema Secondary to Retinal Vein Occlusion.

Jan 30, 2020

The aim of this study was to examine 12-month outcomes of eyes switched from intravitreal ranibizumab or bevacizumab to aflibercept for cystoid macular edema due to retinal vein occlusion (RVO).Retros...

Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice.

Jan 30, 2020

Diabetic retinopathy (DR) is a significant cause of blindness in working-age adults worldwide. Lack of effective strategies to prevent or reduce vision loss is a major problem. Since the degeneration ...

Do we have enough ophthalmologists to manage vision-threatening diabetic retinopathy? A global perspective.

Jan 30, 2020

We aimed to estimate the supply of ophthalmologists in relation to the global and regional burden of vision-threatening diabetic retinopathy (VTDR). Diabetes mellitus (DM) population data from seven w...

Diabetes retinopathy and related health management in Asians versus whites using BRFSS 2005-2017 data.

Jan 30, 2020

Asian Americans had high rate of type 2 diabetes and less risk for diabetes complications compared to white. The purpose of this study was to examine diabetic retinopathy and related healthcare manage...

The Diameter of Retinal Arterioles Is Unaffected by Intravascular Administration of the Adenosine A Receptor Agonist Regadenoson in Normal Persons.

Jan 30, 2020

The neurotransmitter adenosine has been proposed to be involved in the pathogenesis of diabetic retinopathy, which may be due to the vasoactive properties of the compound. Previous studies have shown ...

Antioxidant status in rabbit aqueous humor after instillation of ascorbyl laurate-based nanostructures.

Jan 30, 2020

BACKGROUND: The aim of this work was evaluate the antioxidant effect of ascorbyl laurate (ASC12) based nanostructures applied topically to the cornea of ocular normotensive and hypertensive rabbits. T...

Ocular Manifestations In Late Onset Behçet's Disease.

Jan 30, 2020

Behçet's disease is frequent in Tunisia and potentially serious which it can endanger both the vital and visual prognosis. Late occurrence of the disease is uncommon and less frequently investigated....

Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells.

Jan 30, 2020

Vacuolar protein sorting 35 (Vps35) mutations and protein dysfunction have been linked to the hyperphosphorylation and accumulation of tau protein in a number of central neurodegenerative disorders. T...

The Sustained Release of Tafluprost with a Drug Delivery System Prevents the Axonal Injury-induced Loss of Retinal Ganglion Cells in Rats.

Jan 30, 2020

: To investigated whether a new drug delivery system (DDS) could enable the controlled release of tafluprost and suppress retinal ganglion cell (RGC) death in rats after optic nerve transection (ONT)....

Age-Related Eye Disease and Cognitive Function: The Search for Mediators.

Jan 17, 2020

Age-related eye disease may be associated with cognitive decline, but the scientific literature has not been consistent. Furthermore, no studies have been able to explain the relationship. Our objecti...

Bioengineered Acellular Dermal Matrix Spacer Grafts for Lower Eyelid Retraction Repair: A Report by the American Academy of Ophthalmology.

Jan 17, 2020

To review the literature on the efficacy and safety of bioengineered acellular dermal matrix (BADM) grafts for lower eyelid retraction repair.A literature search was conducted in the PubMed database i...

A case of bilateral acute depigmentation of the Iris in one of two identical twins.

Jan 17, 2020

Bilateral Acute Depigmentation of the Iris (BADI) is a condition which was first described in a case series from Turkey by Tugal-Tutkin and Urgancioglu in (Graefes Arch Clin Exp Ophthalmol 244:742-6, ...

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