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Ophthalmology General

Visual loss and optic neuropathy in a patient with Klinefelter's syndrome, open-angle glaucoma, vitamin B (cobalamin) and folate deficiency.

Feb 28, 2022

A 54-year-old man with Klinefelter's syndrome presented to the neuro-ophthalmology clinic with progressive painless visual blurring in the right eye over 2 years. He was receiving intramuscular testos...

Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.

Feb 28, 2022

Serine/threonine protein kinase 25 (STK25) has critical importance for diabetic complications. However, whether STK25 has a link with diabetic retinopathy is not clearly understood. The damages of ret...

Multimodal image encoding pre-training for diabetic retinopathy grading.

Feb 28, 2022

Diabetic retinopathy is an increasingly prevalent eye disorder that can lead to severe vision impairment. The severity grading of the disease using retinal images is key to provide an adequate treatme...

Long term outcomes from the HORIZON randomized trial for a Schlemm's canal microstent in combination cataract and glaucoma surgery.

Feb 28, 2022

5-year results of the HORIZON trial comparing cataract surgery combined with an intracanalicular microstent to cataract surgery alone.Prospective, multicenter, controlled randomized clinical trial.Pat...

Multifaceted Amblyopia Screening with blinq, 2WIN, and PDI Check.

Feb 28, 2022

Novel devices target different facets of amblyopia risk factors (ARFs). Through birefringence, the Rebion blinq assesses binocular foveation. The Adaptica 2WIN is a multiradial infrared photorefractor...

Dexamethasone Implant for Diabetic Macular Oedema: 1-Year Treatment Outcomes from the Fight Retinal Blindness! Registry.

Feb 21, 2022

Phase III clinical trials of dexamethasone intravitreal implant for diabetic macular oedema (DMO) have reported significant improvements in visual acuity (VA). Studies evaluating the treatment of DMO...

Vector analysis of moderate to high myopic astigmatism after small-incision lenticule extraction (SMILE): 12-month follow-up.

Feb 21, 2022

To evaluate the refractive outcomes of small-incision lenticule extraction (SMILE) surgery in moderate to high myopic astigmatism.Prospective interventional case series.This study evaluated 111 eyes o...

Alterations of lower- and higher-order aberrations after unilateral horizontal rectus muscle surgery in children with intermittent exotropia: A retrospective cross-sectional study.

Feb 21, 2022

This retrospective, cross-sectional study investigated changes in corneal lower- and higher-order aberrations that cause visual disturbance after lateral rectus recession and medial rectus resection i...

Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1 mediated mitophagy.

Feb 21, 2022

To investigate the role and mechanism of melatonin-loaded polymer polyvinyl caprolactam-polyvinyl acetate-polyethyleneglycol graft copolymer (PVCL-PVA-PEG) micelles (Mel-Mic) in dry eye disease (DED)....

Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort.

Feb 21, 2022

We hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range (high ACR) are at greater risk of three-step diabetic retin...

Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion.

Feb 21, 2022

Autophagy and exosome secretion in photoreceptor and RPE cells play an important role during diabetic retinopathy (DR). Thioredoxin (Trx) upregulation delays diabetes-induced photoreceptor cell degene...

Anti-Vascular Endothelial Growth Factor Drug Conbercept-Loaded Peptide Hydrogel Reduced Angiogenesis in the Neovascular Age-Related Macular Degeneration.

Feb 21, 2022

Age-related macular degeneration (AMD) accounts for 8.7% of the global blindness and neovascular form of AMD (nAMD) occupies a large proportion of severe visual loss and legal blindness caused by AMD ...

Virtual Reality and Augmented Reality- Emerging Screening and Diagnostic Techniques in Ophthalmology: a Systematic Review.

Feb 21, 2022

In healthcare, virtual reality (VR) and augmented reality (AR) have been applied extensively for many purposes. Similar to other technologies such as telemedicine and artificial intelligence, VR and A...

Teaching home tonometry using a remote video link.

Feb 21, 2022

Intraocular pressure (IOP) is the primary modifiable risk factor in the progression of glaucoma. The ICare HOME is a self-tonometer which empowers patients to measure their own IOP and allows a more c...

Risk factors, causative organisms and sensitivity patterns of infective keratitis in a tertiary care hospital in Rawalpindi.

Feb 14, 2022

To determine the risk factors, causative organisms, sensitivity patterns and treatment outcomes of infective corneal ulcers.The prospective cohort study was conducted from January 2018 to December 201...

Assessment of Refractive Outcome of Photo Refractive Keratectomy in Myopia and Myopic Astigmatism.

Feb 14, 2022

To determine the refractive outcomes of wavefront optimized photo refractive keratectomy (PRK) in patients having myopia and myopic astigmatism in terms of efficacy, safety, accuracy, stability and pr...

Comparison of transepithelial and conventional photorefractive keratectomy in myopic and myopic astigmatism patients: a randomized contralateral trial.

Feb 14, 2022

To assess transepithelial photorefractive keratectomy (tPRK) in terms of corneal epithelial healing rate, postoperative pain, postoperative discomfort, and visual and refraction outcomes compared to m...

[Dry eye and qualitative tear alteration in essential blepharospasm].

Feb 14, 2022

We aimed to analyze the tears of patients with Benin Essential Blepharospasm (BEB) to explore possible corneo-conjunctival mechanisms for photophobia, tear deficiency and ocular pain.Using an observat...

Tear film and ocular surface neuropeptides: Characteristics, synthesis, signaling and implications for ocular surface and systemic diseases.

Feb 14, 2022

Ocular surface neuropeptides are vital molecules primarily involved in maintaining ocular surface integrity and homeostasis. They also serve as communication channels between the nervous system and th...

Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.

Feb 14, 2022

Diabetic retinopathy (DR) manifests as a complicated and blinding complication in diabetes mellitus. First-line treatments for advanced DR have shown ocular side-effects in some patients. Ginsenoside ...

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