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Ophthalmology General

Phase 1 Dose-Escalation Study of Plasma Kallikrein Inhibitor THR-149 for the Treatment of Diabetic Macular Edema.

Dec 27, 2021

The purpose of this study was to evaluate the safety and preliminary efficacy of a single intravitreal injection of 3 dose levels of THR-149 in adults with center-involved diabetic macular edema (DME)...

The effect of psychotherapy on anxiety, depression, and quality of life in patients with diabetic retinopathy: A protocol for systematic review and network meta-analysis.

Dec 27, 2021

Diabetic retinopathy (DR) is one of the common microvascular complications in diabetic patients, which is characterized by progressive development and often leads to irreversible visual impairment. Mo...

Periocular Adverse Reactions to Omidenepag Isopropyl: Periocular Adverse Reactions to Omidenepag Isopropyl.

Dec 27, 2021

To investigate the periocular adverse reactions to omidenepag isopropyl (OMDI).Non-randomized comparative clinical study.We enrolled 100 patients (100 eyes) with primary open-angle glaucoma or ocular ...

Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis.

Dec 27, 2021

To evaluate the performance of machine learning (ML) in detecting glaucoma using fundus and retinal optical coherence tomography (OCT) images.Meta-analysis.PubMed and EMBASE were searched on August 11...

Limitations in cataract surgical services for children in Ethiopia: a nationwide survey of pediatric cataract surgeons.

Dec 27, 2021

Bilateral cataract is a significant cause of blindness in children in Ethiopia. This study aimed to identify the resources available for cataract surgery in children, and to assess current surgical pr...

Perceptions of Respect From Clinicians by Patients in Racial and Ethnic Minority Groups With Eye Disease.

Dec 20, 2021

The perception of being treated with respect by clinicians may be a driver of disparities in individuals in racial and ethnic minoritie groups with eye diseases. Understanding these drivers may help i...

Visual and Refractive Outcomes of Toric Implantable Collamer Lens Implantation in Stable Keratoconus After Combined Topography-Guided PRK and CXL.

Dec 20, 2021

To evaluate the safety and efficacy of toric implantable Collamer lens (ICL) (STAAR Surgical) implanted at least 6 months after combined topography-guided photorefractive keratotomy (TG-PRK) and corne...

Effect of Central Corneal Thickness on Corneal Higher Order Aberrations After Cataract Surgery.

Dec 20, 2021

To investigate the changes of corneal higher order aberrations (HOAs) before and after phacoemulsification in patients with different central corneal thickness (CCT).In this retrospective non-randomiz...

Incidence and Risk Factors of Dry Eye in Children and Adolescents With Diabetes Mellitus: A 3-Year Follow-Up Study.

Dec 20, 2021

To investigate the incidence and risk factors of dry eye in children with diabetes mellitus (DM) over a period of 3 years. Children and adolescents with DM (age: 3-14 years) from the Shanghai Childr...

Meibomian Gland Morphology Changes After Cataract Surgery: A Contra-Lateral Eye Study.

Dec 20, 2021

To evaluate the morphology changes of meibomian glands (MGs) after cataract surgery. Hangzhou Branch of the Eye Hospital of Wenzhou Medical University, Zhejiang, China. In this contra-lateral eye s...

[Smartphone-based fundus imaging: applications and adapters].

Dec 20, 2021

Smartphone-based fundus imaging (SBFI) is an innovative and low-cost alternative for color fundus photography. Since the first reports on this topic more than 10 years ago a large number of studies ...

Development and optimization of Riluzole-loaded biodegradable nanoparticles incorporated in a mucoadhesive in situ gel for the posterior eye segment.

Dec 20, 2021

Riluzole-loaded PLGA nanoparticles (RLZ-NPs) were developed to improve the biopharmaceutical profile of RLZ after ocular administration. Moreover, RLZ-NPs were dispersed in an in situ gelling system (...

Fungal keratitis: A review of clinical presentations, treatment strategies and outcomes.

Dec 20, 2021

Infectious keratitis is a significant cause of corneal blindness worldwide. Although less prevalent in the developed world, cases of fungal keratitis account for almost half of all keratitis cases, oc...

Penetrating Excimer Laser Keratoplasty with vs without the Homburg Cross-Stitch Marker in Inexperienced Surgeons.

Dec 20, 2021

The Homburg cross-stitch marker, according to Suffo, was developed in 2017 in the Department of Ophthalmology at Saarland University Medical Center. With this instrument, a surgeon can precisely defin...

Can the long term using of pregabalin in fibromyalgia affect the choroid and retinal nerve fiber layer?

Dec 13, 2021

In this study, the effects of long-term pregabalin use on the choroid and retinal nerve fiber layer were investigated in the fibromyalgia disease.The patient group consisted of 41 fibromyalgia patient...

Scholarly Impact of Academic Ophthalmologists and Vision Scientists in Canada.

Dec 13, 2021

To outline the current impact of Canadian ophthalmology and vision science research as measured by novel research metrics.Cross-sectional survey.All Canadian ophthalmologists (n = 687) and vision scie...

Rift Valley Fever Virus Propagates in Human Villous Trophoblast Cell Lines and Induces Cytokine mRNA Responses Known to Provoke Miscarriage.

Nov 29, 2021

The mosquito-borne Rift Valley fever (RVF) is a prioritised disease that has been listed by the World Health Organization for urgent research and development of counteraction. Rift Valley fever virus ...

Increasing trend in rhegmatogenous retinal detachment in Korea from 2004 to 2015.

Nov 29, 2021

To determine the 12-year incidence of and trends in rhegmatogenous retinal detachment (RRD) requiring surgery in Korea.This was a nationwide, population-based, retrospective study. We identified 53,17...

High myopia and macular vascular density: an optical coherence tomography angiography study.

Nov 29, 2021

To investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography ...

Development of Lutein-Containing Eye Drops for the Treatment of Dry Eye Syndrome.

Nov 29, 2021

Dry eye syndrome (DES) is a common ophthalmological disease that decreases tear secretion and causes dryness, photophobia, pain, severe corneal rupture, and even blindness. Ocular and lacrimal gland i...

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