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Ophthalmology General

Correlation between Optical Coherence Tomography Angiography and Multifocal Electroretinogram Findings in Patients with Diabetes Mellitus.

Oct 04, 2021

Diabetic retinopathy is characterized by microvascular, neural and glial cell damage. Optical coherence tomography angiography (OCTA) can detect subclinical microvasculopathy while multifocal electror...

Beta-adrenergic glaucoma eye drops reduce lymphatic clearance from the eye: A sequential photoacoustic imaging study.

Oct 04, 2021

Our study aims to determine whether the beta-adrenergic system is involved in the regulation of lymphatic drainage from the eye. For this purpose, we assessed the effect of 2 topical beta-adrenergic b...

Parkin Prevents Glutamate Excitotoxicity Through Inhibiting NLRP3 Inflammasome in Retinal Ganglion Cells.

Oct 04, 2021

Glutamate excitotoxicity is one of the important pathophysiological culprits in retinal ganglion cells (RGCs) damage after acute optic nerve injury such as traumatic optic neuropathies and glaucoma. I...

Utilization of Remote Diabetic Retinal Screening in a Suburban Healthcare System.

Oct 04, 2021

We conducted a cross-sectional study to assess the utilization of a tele-ophthalmology screening program in a low-risk, suburban population of patients with diabetes.A total of 214 diabetic patients w...

Suppression of Diurnal (9AM-4PM) IOP Fluctuations with Minimally Invasive Glaucoma Surgery: An Analysis of Data from the Prospective, Multicenter, Single-Arm GEMINI Study.

Oct 04, 2021

This study analyzes diurnal IOP data (9AM, 12PM, 4PM) from a prospective 12-month trial of the OMNI Surgical System in open-angle glaucoma (OAG) patients with the aim of evaluating effect of MIGS surg...

THE ECONOMIC BURDEN OF VISION LOSS AND BLINDNESS IN THE UNITED STATES.

Sep 27, 2021

Approximately 8 million Americans self-report vision loss and blindness (VL), potentially resulting in a significant economic burden.Estimate the economic burden of VL in the US and by state.Analysis ...

Cone photoreceptor density in the Copenhagen Child Cohort at age 16-17 years.

Sep 27, 2021

To examine cone density in relation to gestational and morphological parameters in the Copenhagen Child Cohort (CCC2000).The macula was imaged using adaptive optics in 1,296 adolescents aged 16-17 ye...

Evaluation of the Ocular Surface, Conjunctival Impression Cytology and Meibomian Gland Dropout in Patients with Familial Mediterranean Fever.

Sep 27, 2021

Familial Mediterranean fever (FMF) is an idiopathic disease with chronic inflammation. We aimed to determine the changes caused by the chronic inflammatory nature of FMF on the ocular surface, meibomi...

Downregulation of acylglycerol kinase suppresses high glucose-induced endothelial-mesenchymal transition in HRECs through regulating the LPAR1/TGF-β/Notch signaling pathway.

Sep 27, 2021

The endothelial-mesenchymal transition (EndMT) participates in the progression of diabetic retinopathy (DR), but cell-intrinsic factors modulating this process remain elusive. In this study, we explor...

The dynamic optotype (Dyop): a novel visual acuity test for use in children.

Sep 27, 2021

To evaluate the "dynamic optotype" (Dyop), a simple visual acuity test based on a dynamic target that requires minimal knowledge of symbols and letters.A total of 160 consecutive, systemically healthy...

Visual Outcomes in Eyes with Neovascular Glaucoma and Anterior Segment Neovascularization Without Glaucoma.

Sep 27, 2021

To find predictive factors of neovascular glaucoma (NVG) development in anterior segment neovascularization without glaucoma (ASNVWG) and poor visual outcomes in eyes that have already developed NVG.R...

Quality of life in adults with childhood glaucoma: An interview study.

Sep 27, 2021

To explore and report on the quality of life (QoL) issues encountered by adults with childhood glaucoma.Exploratory qualitative study.Forty-seven participants with childhood glaucoma (defined as disea...

Retinal Capillary Basement Membrane

Sep 21, 2021

This study states that the Vascular basement membrane (BM) thickening has been hailed over half a century as the most prominent histological lesion in diabetic microangiopathy, and represents an early...

Compound heterozygous mutations in the LTBP2 gene associated with microspherophakia in a Chinese patient: a case report and literature review.

Sep 20, 2021

Microspherophakia (MSP, OMIM 251,750) is a rare inherited autosomal recessive eye disorder characterized by small spherically shaped lens. Several studies have indicated that the transforming growth...

Compound heterozygous KCNV2 variants contribute to cone dystrophy with supernormal rod responses in a Chinese family.

Sep 20, 2021

Cone dystrophy with supernormal rod response (CDSRR) is an autosomal recessive retinal disorder characterized by myopia, dyschromatopsia, nyctalopia, photophobia, and nystagmus. CDSRR is caused by mut...

Emerging therapeutic opportunities for integrin inhibitors.

Sep 20, 2021

Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLÎ...

Effect of ethnicity and other sociodemographic factors on attendance at diabetic eye screening: a 12-month retrospective cohort study.

Sep 20, 2021

To examine the association of sociodemographic characteristics with attendance at diabetic eye screening in a large ethnically diverse urban population.Retrospective cohort study.Screening visits in t...

Sight-threatening retinopathy in 9 adolescents with early-onset type 1 diabetes.

Sep 20, 2021

In adults, there has been a decline in the incidence of diabetic retinopathy associated with improvements in diabetes management. Data on incident severe diabetic retinopathy in adolescents are sparse...

Juvenile-onset Open-angle Glaucoma - A Clinical and Genetic Update.

Sep 20, 2021

Juvenile-onset open-angle glaucoma (JOAG) is a subset of primary open-angle glaucoma that is diagnosed before 40 years of age. The disease may be familial or non-familial, with proportions varying amo...

A Genotype-Phenotype Analysis of the Bardet-Biedl Syndrome in Puerto Rico.

Sep 20, 2021

Bardet-Biedl syndrome is a complex heterogeneous ciliopathy caused by genetic mutations. Although establishing genotype-phenotype correlations has been challenging, some regional variations have been ...

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