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Ophthalmology General

Pretreatment with frequent topical betamethasone in Ahmed glaucoma valve implantation.

Jun 03, 2021

To evaluate the efficacy of pretreatment with topical betamethasone in Ahmed glaucoma valve (AGV) implantation.Randomized clinical trial.Sixty-two eyes from 62 patients undergoing AGV.We randomly assi...

Large-scale machine learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology.

Jun 03, 2021

Genome-wide association studies (GWASs) require accurate cohort phenotyping, but expert labeling can be costly, time intensive, and variable. Here, we develop a machine learning (ML) model to predict ...

Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA.

Jun 03, 2021

Cupping of the optic nerve head, a highly heritable trait, is a hallmark of glaucomatous optic neuropathy. Two key parameters are vertical cup-to-disc ratio (VCDR) and vertical disc diameter (VDD). Ho...

AUTHENTIC RESEARCH IN THE CLASSROOM INCREASES APPRECIATION FOR PLANTS IN UNDERGRADUATE BIOLOGY STUDENTS.

May 31, 2021

Engaging students in authentic research increases student knowledge, develops STEM skills, such as data analysis and scientific communication, and builds community. Creating authentic research opportu...

Risk Factors for Corneal Striae in Eyes after Glaucoma Surgery.

May 31, 2021

Eyes with corneal striae had steeper cornea, induced astigmatism, and higher corneal hysteresis, which implies a relationship between striae, corneal shape, and the cornea's resistance to deformation ...

Intraocular epidermal growth factor concentration, axial length, and high axial myopia.

May 31, 2021

Various molecules such as dopamine have been found to be associated with axial elongation in experimental studies. Here, we examined whether intraocular EGF is associated with axial length in myopic p...

A multicenter clinical trial of orthokeratology in school-aged children and adolescents in Japan.

May 31, 2021

This study investigated the safety and efficacy of orthokeratology in myopic children in Japan.Prospective clinical trial.This study enrolled myopic children aged 6-16 years with a spherical equivale...

Impact of virtual reality headset use on eye blinking and lipid layer thickness.

May 31, 2021

Blinking plays an important role in protecting the eyes, and the use of computers has been associated with a reduction in the blink rate. The goal of this study was to evaluate the effect of a virtual...

Combined Intense Pulsed Light and Low-Level Light Therapy for the Treatment of Dry Eye: A Retrospective Before-After Study with One-Year Follow-Up.

May 31, 2021

To assess the effectiveness of a combination of intense pulsed light and low-level light therapy (IPL/LLLT) for the treatment of dry eye.Retrospective before-after single-center clinical study.Patient...

Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation.

May 31, 2021

Dry eye disease (DED) affects hundreds of millions of people worldwide. It is characterized by the production of inflammatory cytokines and chemokines as well as damaging matrix metalloproteinases (MM...

Efficacy of calcium dobesilate in treating Chinese patients with mild-to-moderate non-proliferative diabetic retinopathy (CALM-DR): protocol for a single-blind, multicentre, 24-armed cluster-randomised, controlled trial.

May 31, 2021

Calcium dobesilate (CaD) has been used in the treatment of diabetic retinopathy (DR) due to its potential in protecting against retinal vascular damage. However, there is limited evidence exploring it...

A deep learning system for detecting diabetic retinopathy across the disease spectrum.

May 31, 2021

Retinal screening contributes to early detection of diabetic retinopathy and timely treatment. To facilitate the screening process, we develop a deep learning system, named DeepDR, that can detect ear...

Analysis of progressive neovascularization in diabetic retinopathy using widefield optical coherence tomography angiography.

May 31, 2021

To quantitatively and morphologically document enlarged neovascularization elsewhere (NVE) using widefield swept-source (SS) optical coherence tomography angiography (OCTA) with vitreoretinal interfac...

Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study.

May 31, 2021

To compare the effectiveness and safety of the MicroShunt versus trabeculectomy in patients with primary open-angle glaucoma (POAG).One-year results from a 2-year, prospective, randomized, multicenter...

Semi-AI and Full-AI digitizer: The ways to digitalize visual field big data.

May 31, 2021

Glaucoma is one of the major diseases that cause blindness, which is incurable and irreversible, and it is essential to detect glaucoma vision deficits in treatment and check the progression of vision...

Sensitive period for the plasticity of alpha activity in humans.

May 31, 2021

Visual experience is crucial for the development of neural processing. For example, alpha activity development is a vision-dependent mechanism. Indeed, studies report no alpha activity is present in b...

Detection and Referral of Orbital and Ocular Injuries Associated With Intimate Partner Violence Following an Educational and Screening Initiative in an Emergency Department.

May 31, 2021

Intimate partner violence (IPV) is a substantial cause of morbidity and mortality in the US. Previous studies indicate gaps in identifying and referring female patients with IPV-associated orbital and...

Partial recovery of visual function in a blind patient after optogenetic therapy.

May 27, 2021

Optogenetics may enable mutation-independent, circuit-specific restoration of neuronal function in neurological diseases. Retinitis pigmentosa is a neurodegenerative eye disease where loss of photorec...

Utilizing a responsive web portal for studying disc tracing agreement in retinal images.

May 27, 2021

Glaucoma is a leading cause of blindness worldwide whose detection is based on multiple factors, including measuring the cup to disc ratio, retinal nerve fiber layer and visual field defects. Advances...

Axial length and its relationship to refractive error in Chinese university students.

May 27, 2021

To investigate the relationship between axial length (AL) and refractive error (RE).Participants comprised Chinese university students. In total, 894 eyes with low hyperopia to emmetropia (-0.50D ≤ ...

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