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Ophthalmology General

Assessment of four validated questionnaires for screening of dry eye disease in an African cohort.

May 24, 2021

To evaluate the 5-item dry eye questionnaire (DEQ-5) for measurement precision and unidimensionality, and assess the ability of Ocular Surface Disease Index (OSDI), McMonnies Dry Eye Questionnaire (MQ...

The role of KPI-121 0.25% in the treatment of dry eye disease: penetrating the mucus barrier to treat periodic flares.

May 24, 2021

The tear film, which includes mucins that adhere to foreign particles, rapidly clears allergens and pathogens from the ocular surface, protecting the underlying tissues. However, the tear film's abili...

Ocular Involvement in COVID-19: Conjunctivitis and More.

May 24, 2021

Since the beginning of 2020, SARS-CoV-2, the pathogen of COVID-19, has led to a global pandemic that also affects ophthalmology. Ophthalmologists can be confronted at any time with potentially COVID-1...

Delay in seeking medical care after the onset of symptoms in patients with sight-threatening diabetic retinopathy.

May 24, 2021

To investigate the reasons for delays in seeking medical care in patients with diabetic retinopathy and associated risk factors.We retrospectively reviewed data for patients with sight-threatening dia...

HIF1α-PFKFB3 Pathway’s Role In Diabetic Retinopathy

May 24, 2021

Diabetic retinopathy (DR) is the leading cause of blindness in adults of developed countries. Both microvasculopathy and neurodegeneration are implicated in mechanisms of DR development, with neuronal...

Neuroprotective role of sphingolipid rheostat in excitotoxic retinal ganglion cell death.

May 24, 2021

The glutamate excitotoxicity has been suggested as a factor involved in the loss of retinal neuronal cells, including retinal ganglion cell (RGC), in various retinal degenerative diseases including is...

Human RGR Gene and Associated Features of Age-related Macular Degeneration Revealed in Models of Retina-Choriocapillaris Atrophy.

May 24, 2021

Age-related macular degeneration (AMD) is a progressive degenerative eye disease that is the most common cause of blindness among elderly humans. AMD is characterized by early atrophy of the choriocap...

Gamma sterilization and in vivo evaluation of cationic nanostructured lipid carriers as potential ocular delivery systems for antiglaucoma drugs.

May 24, 2021

Solid lipid nanoparticles and nanostructured lipid carriers showed promising results for enhancement of ocular bioavailability of drugs with poor corneal permeability. One of these drugs is methazolam...

Genetic Analysis in a Swiss Cohort of Bilateral Congenital Cataract.

May 24, 2021

Identification of geographic population-based differences in genotype and phenotype heterogeneity are important for targeted and patient-specific diagnosis and treatment, counseling, and screening str...

Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis.

May 20, 2021

Uveitis is an ocular inflammation that can affect individuals of all ages and is a major cause of blindness. We have tested the therapeutic efficacy of a cell penetrating peptide from the kinase inhib...

Effect of Scleral Crosslinking Using Multiple Doses of Genipin on Experimental Progressive Myopia in Tree Shrews.

May 20, 2021

To evaluate the effect of scleral crosslinking (SXL) on slowing experimental progressive myopia in tree shrew eyes using sub-Tenon's injections of genipin (GEN) at different concentrations and number ...

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia.

May 20, 2021

The purpose of this study was to investigate the relationship of posterior staphyloma (PS) types in pathological myopia (PM) with age, best-corrected visual acuity (BCVA), spherical equivalent (SE), a...

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity.

May 20, 2021

To compare the patterns of longitudinal refractive error development during the first 3.5 years in children with severe retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IVB) or ...

Improvement of Evaporative Dry Eye With Meibomian Gland Dysfunction in Model Mice by Treatment With Ophthalmic Solution Containing Mineral Oil.

May 20, 2021

Meibomian gland dysfunction (MGD) is a major cause of evaporative dry eye. The purpose of this study is to assess the efficacy of a mineral oil-containing ophthalmic solution (MO) in mitigating the ev...

Smart Eye Camera: A Validation Study for Evaluating the Tear Film Breakup Time in Human Subjects.

May 20, 2021

This study aimed to demonstrate the efficacy of a "Smart Eye Camera (SEC)" in comparison with the efficacy of the conventional slit-lamp microscope by evaluating their diagnostic functionality for dry...

A Novel Rabbit Dry Eye Model Induced by a Controlled Drying System.

May 20, 2021

To establish an environment-induced dry eye model in rabbits using a controlled drying system (CDS).Rabbits were randomly divided into two groups. The rabbits in the dry group were housed in the CDS, ...

Sex-Based Analysis of Potential Inflammation-Related Protein Biomarkers in the Aqueous Humor of Patients With Diabetes Mellitus.

May 20, 2021

To investigate whether men have higher inflammatory protein biomarker concentrations in their aqueous humor (AH) compared with women in groups of patients with varying levels of diabetic disease.This ...

Validation of a Diagnostic Support System for Diabetic Retinopathy Based on Clinical Parameters.

May 20, 2021

To validate a clinical decision support system (CDSS) that estimates risk of diabetic retinopathy (DR) and to personalize screening protocols in type 2 diabetes mellitus (T2DM) patients.We utilized a ...

Spleen Tyrosine Kinase Mediates Microglial Activation in Mice With Diabetic Retinopathy.

May 20, 2021

Diabetic retinopathy (DR) is a leading cause of blindness in developed countries, in which microglial activation is involved. However, the mechanism of microglial activation in DR remains largely unkn...

High-Pass Visual Acuity Loss and Macular Structure-Function Relationship in Patients With Primary Open-Angle Glaucoma.

May 20, 2021

The Logarithm of the Minimum Angle of Resolution (logMAR) chart is the most common clinical test for assessing central visual function in glaucoma. However, based on the use of these charts, visual ac...

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