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Ophthalmology General

Remnant cholesterol predicts progression of diabetic nephropathy and retinopathy in type 1 diabetes.

May 10, 2021

We aimed to assess whether remnant cholesterol concentration and variability predict the progression of diabetic nephropathy (DN) and severe diabetic retinopathy (SDR) in type 1 diabetes.This observat...

Amelioration of diabetic retinopathy in db/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F.

May 10, 2021

Berberis dictyophylla F., a famous Tibetan medicine, has been used to prevent and treat diabetic retinopathy (DR) for thousands of years in clinic. However, its underlying mechanisms remain unclear.Th...

Inter-eye relationship of intraocular pressure change after unilateral trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation.

May 10, 2021

This study assesses short-term intraocular pressure (IOP) change in the fellow eye of glaucoma patients after mitomycin C-augmented trabeculectomy, filtering canaloplasty, or PreserFlo™ microsh...

Joint optic disc and optic cup segmentation based on boundary prior and adversarial learning.

May 10, 2021

The most direct means of glaucoma screening is to use cup-to-disc ratio via colour fundus photography, the first step of which is the precise segmentation of the optic cup (OC) and optic disc (OD). In...

New Compound Heterozygous CYP4V2 Mutations in Bietti Crystalline Corneoretinal Dystrophy.

May 10, 2021

Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessive retinal dystrophy which is caused by the mutations of CYP4V2, usually progressing to legal blindness by the 5th or 6th decade...

Patient and Resource Management of Emergency Walk-In Clinic During a COVID-19 Pandemic State Lockdown.

May 10, 2021

To gather data on the most common chief complaints, diagnoses, in-office procedures, and surgeries that presented to the Kresge Eye Institute's Emergency Clinic in Detroit, Michigan during the COVID-1...

Diagnostic accuracy of current machine learning classifiers for age-related macular degeneration: a systematic review and meta-analysis.

May 10, 2021

The objective of this study was to systematically review and meta-analyze the diagnostic accuracy of current machine learning classifiers for age-related macular degeneration (AMD). Artificial intelli...

Postoperative Photoreceptor Integrity in Retinal Detachment Repair

May 06, 2021

Pneumatic retinopexy (PnR) is a condition associated with reduced vertical metamorphosis and greater visual acuity compared to pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment...

Racial/Ethnic Disparities in Ophthalmology Clinical Trials

May 06, 2021

Representative and diverse enrollment in pivotal clinical trials is crucial for adequately powering subgroup analysis and ensuring credibility, equity, and validity of the results. This study aims to ...

Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration.

May 06, 2021

Limbal stem cells (LSC) maintain the transparency of the corneal epithelium. Chemical burns lead the loss of LSC inducing an up-regulation of pro-inflammatory and pro-angiogenic factors, triggering co...

Strehl Ratio and Myopia in Chinese Adolescents: The Tuyou County Pediatric Eye (TYPE) Study.

May 06, 2021

To investigate the relationships between property of the visual quality, Strehl ratio (SR) and the degree of myopia.A total of 444 anatomically normal eyes of 222 adolescents were enrolled in the TYPE...

Axial length targets for myopia control.

May 06, 2021

Both emmetropic and myopic eyes elongate throughout childhood. The goals of this study were to compare axial elongation among untreated progressing myopes, progressing myopes treated with a myopia con...

Genetic testing results of children suspected to have Stickler syndrome type collagenopathy after ocular examination.

May 06, 2021

Stickler syndrome is a collagenopathy that is typically COL2A1-related (autosomal dominant) and less commonly related to other collagen gene mutations. Diagnosis is straightforward when a child has my...

Patient-reported experience of dry eye management: An international multicentre survey.

May 06, 2021

To explore the journey taken by patients in a range of different countries to manage their dry eye symptoms.Members of the general public who responded positively to the question "Do your eyes ever fe...

Pathophysiology of Meibomian Glands - An Overview.

May 06, 2021

: The meibomian glands are located in the tarsal plate of the upper and lower eyelid and are responsible for the production of a lipid-rich secretion, the meibum, which forms the outer component of th...

Established soft contact lens wearers' awareness of and initial experiences with orthokeratology.

May 06, 2021

To understand the initial awareness of and experience with orthokeratology in a group of adult, symptomatic, soft contact lens (CL) wearers.This was a prospective, 3-month, open-label study of symptom...

Bilirubin is inversely related to diabetic peripheral neuropathy assessed by sural nerve conduction study.

May 06, 2021

Diagnosis of diabetic peripheral neuropathy (DPN) depends on subjective findings, disturbing certain investigations for DPN risks. Bilirubin protects against vascular complications by reducing oxidati...

Erectile Dysfunction in Type-2 Diabetes Mellitus Patients: Predictors of Early Detection and Treatment.

May 06, 2021

To identify risk factors and potential predictors of erectile dysfunction (ED) in type-2 diabetes mellitus (T2DM) patients for early detection and treatment.A retrospective cohort was used to assess t...

Laser in Glaucoma and Ocular Hypertension Trial (LIGHT) in China A Randomized Controlled Trial: Design and Baseline Characteristics.

May 06, 2021

To describe the baseline characteristics of a trial to evaluate whether selective laser trabeculoplasty (SLT), as a first-line treatment, provides superior economic and health-related quality of life ...

Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy.

May 06, 2021

The major event in the development of diabetes-related blindness and vision impairment is the onset of retinal cell damage. Overall awareness of insulin-like growth factor-2 (IGF2) mechanisms emphasiz...

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