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Ophthalmology General

Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.

May 06, 2021

Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF) that has been used as a systemic chemotherapy treatment of various malignancies in adults since 2000. It has...

Pilot Study of Clinician-Patient Collaboration in Glaucoma.

May 06, 2021

This pilot study was undertaken to examine the feasibility of a larger scale trial examining the effect of interventions to improve patient-clinician collaboration. The primary outcome was the extent ...

Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies.

May 03, 2021

Neural cell death is the main feature of all retinal degenerative disorders that lead to blindness. Despite therapeutic advances, progression of retinal disease cannot always be prevented, and once ne...

The Spectrum of Maculopathy in Mitochondrial DNA A3243G Mutation: A Case Series of Six Patients.

May 03, 2021

The mitochondrial DNA (mtDNA) A3243G point mutation encompasses a heterogenous group of disorders including mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), maternally ...

Clinical Classification of Acquired Concomitant Esotropia.

May 03, 2021

Classification and management of acquired concomitant esotropia is controversial. We sought to establish a simple clinical classification in order to determine in which cases further investigations in...

Characteristics of progressive temporal visual field defects in patients with myopia.

May 03, 2021

Temporal visual field damage (VFD) is the common type of non-glaucomatous VF defects found in eyes with myopia. However, little is known about the factors associated with its progression. We investiga...

Computerised dynamic posturography for postural control assessment in subjects wearing multifocal contact lenses dedicated for myopia control.

May 03, 2021

To measure body balance using computerised dynamic posturography in young adults wearing multifocal contact lenses (MFCL) with high addition powers designed for myopia control.Twenty-four young adults...

Optimization of goblet cell density quantification methods.

May 03, 2021

The purpose of this study was to develop a standardized, accurate and efficient method for estimating conjunctival goblet cell density (GCD) via optimizing sample storage conditions and quantification...

Inducing dry eye disease using a custom engineered desiccation system: Impact on the ocular surface including keratin-14-positive limbal epithelial stem cells.

May 03, 2021

Dry eye disease (DED) is characterized by loss of tear film stability that becomes self-sustaining in a vicious cycle of pathophysiological events. Currently, desiccation stress (DS) is the dominant p...

Neuropathic corneal pain and dry eye: a continuum of nociception.

May 03, 2021

Throughout the body, damage to peripheral nerves normally involved in nociception may produce a constellation of symptoms-including irritation, itchiness and pain. The neurobiological processes involv...

Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets.

May 03, 2021

Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading cause of visual loss in working-age individuals in many industrialized countries. It has been traditionally regar...

Plasma miR-26a-5p is a biomarker for retinal neurodegeneration of early diabetic retinopathy.

May 03, 2021

Retinal neurodegeneration is an early pathological change in diabetic retinopathy (DR). Early-stage retinal neurodegeneration is usually asymptomatic. This study aims to identify circulating microRNAs...

Simultaneous determination of six main components in Bushen Huoxue prescription by HPLC-CAD.

May 03, 2021

The Bushen Huoxue prescription is a traditional Chinese medicine formula treating diabetic retinopathy, which was developed by our research group. Catalpol, puerarin, salvianolic acid B, ginsenoside R...

[Micropulse cyclophotocoagulation lowers the intraocular pressure: half year results].

May 03, 2021

Cyclophotocoagulation (CPC) is a simple noninvasive and quickly available procedure for lowering intraocular pressure but due to its dreaded potential for complications it continues to play an outsid...

[Screening for retinopathy of prematurity-the most important changes in the new German guidelines 2020].

May 03, 2021

Due to improvements in neonatal care of premature infants and the development of novel treatment options for retinopathy of prematurity (ROP), the requirements for screening for ROP have changed since...

Naturalistic Driving Techniques and Association of Visual Risk Factors With At-Fault Crashes and Near Crashes by Older Drivers With Vision Impairment.

May 03, 2021

Government motor vehicle crash reports used in the study of driver safety can be biased and incomplete. Naturalistic driving methods using in-vehicle instrumentation have been developed in recent year...

Evaluation of the Manchester COVID-19 Urgent Eyecare Service (CUES).

May 03, 2021

Pressure on capacity in ophthalmology alongside the coronavirus (COVID-19) pandemic led to the development of the COVID-19 Urgent Eyecare Service (CUES), allowing patients to receive a prompt ophthalm...

The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems.

Apr 29, 2021

Diseases that result in retinal pigment epithelium (RPE) degeneration, such as age-related macular degeneration (AMD), are among the leading causes of blindness worldwide. Atrophic (dry) AMD is the mo...

Discovery of Novel Small-Molecule Antiangiogenesis Agents to Treat Diabetic Retinopathy.

Apr 29, 2021

Diabetic retinopathy is the leading cause of blindness which is associated with excessive angiogenesis. Using the structure of wondonin marine natural products, we previously created a scaffold to dev...

Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methods.

Apr 29, 2021

Myopic maculopathy (MM) is the most serious and irreversible complication of pathologic myopia, which is a major cause of visual impairment and blindness. Clinic proposed limited number of factors rel...

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