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Ophthalmology General

Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema.

Apr 26, 2021

Diabetic macular edema (DME) is the most common cause of vision loss in diabetic retinopathy, affecting 1 in 15 patients with diabetes mellitus (DM). The disruption of the inner blood-retina barrier (...

The risk of micro and macrovascular disease in Egyptian patients with diabetes and peripheral arterial disease.

Apr 26, 2021

: The aim of this study was to assess the prevalence of micro- and macrovascular disease in Egyptian patients with diabetes mellitus (DM) and peripheral arterial disease (PAD). : The study included 16...

Transthyretin affects the proliferation and migration of human retinal microvascular endothelial cells in hyperglycemia via hnRNPA2B1.

Apr 26, 2021

Transthyretin (TTR) has been proved to repress neovascularization in diabetic retinopathy environment by regulating the molecules in and downstream of the STAT-4/miR-223-3p/FBXW7 signal pathway; howev...

The influence of axial myopia on optic disc characteristics of glaucoma eyes.

Apr 26, 2021

This study characterizes differences in glaucomatous eyes with and without high axial myopia using custom automated analysis of OCT images. 452 eyes of 277 glaucoma patients were stratified into non (...

Anterior versus posterior endoscopic cyclophotocoagulation: comparison of indications, populations, and outcomes.

Apr 26, 2021

To examine how indications, patient characteristics, and outcomes differ between anterior and posterior approaches of endoscopic cyclophotocoagulation (ECP) in the treatment of glaucoma.This is a retr...

Donor demographics and factors affecting corneal utilisation in Eye Bank of North India.

Apr 26, 2021

Nearly 6.8 million people in India have vision less than 6/60 in at least one eye due to corneal diseases; of these, about a million had bilateral involvement.To identify the challenges faced; the tre...

Racial/Ethnic Disparities in Ophthalmology Clinical Trials Resulting in US Food and Drug Administration Drug Approvals From 2000 to 2020.

Apr 26, 2021

Diverse, representative enrollment in pivotal clinical trials is vital to sufficiently power subgroup analyses and ensure equity and validity of trial results.To evaluate the racial/ethnic representat...

Citizen science with colour blindness: A case study on the Forel-Ule scale.

Apr 22, 2021

Many citizen science projects depend on colour vision. Examples include classification of soil or water types and biological monitoring. However, up to 1 in 11 participants are colour blind. We simula...

Identification of patient benefit from proton beam therapy in brain tumour patients based on dosimetric and NTCP analyses.

Apr 22, 2021

The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies, such as the model-based approach. In this study, we assessed the dosimetric benefit of PBT com...

Gene network analyses unveil possible molecular basis underlying drug-induced glaucoma.

Apr 22, 2021

Drug-induced glaucoma (DIG) is a kind of serious adverse drug reaction that can cause irreversible blindness. Up-to-date, the molecular mechanism of DIG largely remains unclear yet due to the medical ...

Coadministration With Carbidopa Enhances the Antimyopic Effects of Levodopa in Chickens.

Apr 22, 2021

Topical application of levodopa inhibits the development of form-deprivation myopia (FDM) and lens-induced myopia (LIM) in chicks. Here we examine whether coadministration with carbidopa enhances this...

Corneal thickness changes in myopic children during and after short-term orthokeratology lens wear.

Apr 22, 2021

To evaluate thickness changes in the central and mid-peripheral cornea (CCT and mPCT), corneal epithelium (CET and mPET) and stroma (CST and mPST) of myopic children during and after short-term orthok...

Protective effects of sunlight exposure against PRK-induced myopia in infant rhesus monkeys.

Apr 22, 2021

Extensive clinical evidence suggests that time spent outdoors might reduce the risk of myopia. This study aimed to determine whether increasing sunlight exposure has a protective effect on hyperopic-d...

Animal Models of Dry Eye: Their Strengths and Limitations for Studying Human Dry Eye Disease.

Apr 22, 2021

Dry eye disease (DED), also called the keratoconjunctivitis sicca (KCS), is one of the most common diseases in the ophthalmology clinics. While DED is not a life-threatening disease, life quality may ...

Dry eye signs and symptoms in patients on aromatase inhibitor therapy.

Apr 22, 2021

The study aimed to test whether symptomatic dry eye in aromatase inhibitor (AI) patients is associated with the clinical features of evaporative dry eye.A cross-sectional, observational study of postm...

Prevalence and risk factors of dry eye disease in young and middle-aged office employee: a Xi'an Study.

Apr 22, 2021

To estimate the prevalence of and risk factors for dry eye disease (DED) in young and middle-aged office employee in Xi'an.This cross-sectional study of the prevalence of and risk factors for DED inve...

A comparison of visual acuity measured by ETDRS chart and Standard Logarithmic Visual Acuity chart among outpatients.

Apr 22, 2021

To compare the results of visual acuity (VA) measured by Early Treatment Diabetic Retinopathy Study (ETDRS) chart, 5 m Standard Logarithm Visual Acuity (5SL) chart, and 2.5 m Standard Logarithm Visual...

A simple new technique for the induction of residual posterior vitreous cortex removal and membrane peeling.

Apr 22, 2021

To describe a quick, cost-effective alternative to using a scraper to remove the residual posterior vitreous cortex and create an inner limiting membrane (ILM) flap during vitrectomy.The surgical tech...

Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study.

Apr 22, 2021

We hypothesize that a collapse of the optic nerve subarachnoid space (ONSAS) in the upright posture may protect the eyes from large translamina cribrosa pressure differences (TLCPD) believed to play a...

Correlation between intraocular pressure obtained with water drinking test versus modified diurnal tension curve measurement in pseudoexfoliation glaucoma.

Apr 22, 2021

The aim of this paper was to study the correlation and agreement between the intraocular pressure (IOP) peak value and fluctuations detected with the modified diurnal tension curve (mDTC) and the wate...

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