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Ophthalmology General

Outcomes and complications of implantable collamer lens for mild to advance keratoconus.

Mar 29, 2021

To evaluate the outcome and safety of implantable collamer lens (ICL; (Visian, STAAR Surgical, Monrovia, CA, USA) in mild to advance keratoconus patients with myopia and myopic astigmatism.This retros...

Associations between visual function and magnitude of refractive error for emmetropic to moderately hyperopic 4- and 5-year-old children in the Vision in Preschoolers - Hyperopia in Preschoolers Study.

Mar 29, 2021

To evaluate associations between visual function and the level of uncorrected hyperopia in 4- and 5-year-old children without strabismus or amblyopia.Children with spherical equivalent (SE) cycloplegi...

Rabbit models of dry eye disease: Current understanding and future needs for translational approaches.

Mar 29, 2021

The dry eye disease (DED) is rising as an eye health pandemic, affecting millions across the world. The development of novel drugs, drug delivery systems, and targeted therapies for addressing the inf...

Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction.

Mar 29, 2021

To evaluate the precorneal tear film (PCTF) and lipid layer (TFLL) thicknesses and thinning rates in meibomian gland dysfunction (MGD) using a combined ultra-high-resolution optical coherence tomograp...

Diquafosol tetrasodium elicits total cholesterol release from rabbit meibomian gland cells via P2Y purinergic receptor signalling.

Mar 29, 2021

Diquafosol tetrasodium (DQS), a purinergic P2Y receptor agonist, stimulates secretion of both water and mucins from the conjunctiva into tears. Hence, DQS-containing eye drops have been approved as a ...

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction.

Mar 29, 2021

Homo sapiens evolved under conditions of intermittent food availability and prolonged fasting between meals. Periods of fasting are important for recovery from meal-induced oxidative and metabolic str...

Evaluation of morphological characteristics of diabetic macular edema in patients with non-proliferative versus proliferative diabetic retinopathy: a spectral-domain optical coherence tomography study.

Mar 29, 2021

To evaluate the morphological characteristics in patients with diabetic macular edema (DME), either with co-existent non-proliferative diabetic retinopathy (NPDR) or with PDR.Retrospective study inclu...

Retrospective study of aflibercept in combination therapy for high-risk proliferative diabetic retinopathy and diabetic maculopathy.

Mar 29, 2021

To evaluate whether anti-vascular endothelial growth factor (VEGF) therapy combined with panretinal photocoagulation could reverse diabetic retinopathy (DR).Fifty-two patients (72 eyes) with high-risk...

The Role of PGS/PCL Scaffolds in Promoting Differentiation of Human Embryonic Stem Cells into Retinal Ganglion Cells.

Mar 29, 2021

The stem cell-based retinal ganglion cells (RGCs) replacement therapy offers a potential to restore vision in progressive optic neuropathies including glaucoma by replacing degenerated RGCs and by sim...

Factors Associated with the Macular Ganglion Cell-Inner Plexiform Layer Thickness in a Cohort of Middle-aged U.S. Adults.

Mar 29, 2021

The macular ganglion cell-inner plexiform layer (mGCIPL) may serve as a quick and easily obtained measure of generalized neurodegeneration. Investigating factors associated with this thickness could h...

Derivation of Induced Pluripotent Stem Cell (iPSC) Lines from Patient-Specific Peripheral Blood Mononuclear Cells (PBMC) Using Episomal Vectors.

Mar 29, 2021

Inherited retinal diseases (IRDs) are a diverse group of rare eye disorders, resulting in vision loss or blindness. The underlying reason is mutation in one or more than 250 different genes associated...

Corneal and lens densitometry in patients with vernal keratoconjunctivitis.

Mar 25, 2021

To evaluate corneal and crystalline lens densitometry in patients with vernal keratoconjunctivitis (VKC).This is a case-control study. Patients with VKC and age-gender-matched healthy controls underwe...

Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation.

Mar 25, 2021

Precise regulation of ocular size is a critical determinant of normal visual acuity. Although it is generally accepted that ocular growth relies on a cascade of signaling events transmitted from the r...

Transepithelial photorefractive keratectomy to treat mild myopia.

Mar 25, 2021

To assess the safety and effectiveness of transepithelial photorefractive keratectomy (T-PRK) in patients with mild myopia using the Schwind Amaris 750 s Excimer laser system which take corneal epith...

Ocular manifestations and biomarkers of Gulf War Illness in US veterans.

Mar 25, 2021

Gulf War Illness (GWI) is a multisystem disease with variable presentations, making diagnosis difficult. Non-invasive biomarkers would aid in disease diagnosis. We hypothesized that the eye could serv...

Prevalence of dry eye syndrome in association with the use of contact lenses in Saudi Arabia.

Mar 25, 2021

Dry eye disease is a tear film disorder which can cause discomfort to patients and negatively affect vision acuity. A number of risk factors has been reported to affect the incidence and severity of d...

Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases (Review).

Mar 25, 2021

The tear film is a layer of body fluid that maintains the homeostasis of the ocular surface. The superior accessibility of tears and the presence of a high concentration of functional proteins make te...

Surgery for idiopathic epiretinal membrane.

Mar 25, 2021

Epiretinal membrane is an abnormal sheet of avascular fibrocellular tissue that develops on the inner surface of the retina. Epiretinal membrane can cause impairment of sight as a consequence of progr...

Protective role of vitamin D against oxidative stress in diabetic retinopathy.

Mar 25, 2021

Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus. There is much evidence showing that a high level of mitochondrial overproduction of reactive oxygen species in the diabe...

Connective tissue growth factor promotes retinal pigment epithelium mesenchymal transition via the PI3K/AKT signaling pathway.

Mar 25, 2021

Proliferative vitreoretinopathy (PVR) is a disease leading to the formation of contractile preretinal membranes (PRMs) and is one of the leading causes of blindness. Connective tissue growth factor (...

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