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Ophthalmology General

Restoration of mGluR6 Localization Following AAV-Mediated Delivery in a Mouse Model of Congenital Stationary Night Blindness.

Mar 18, 2021

Complete congenital stationary night blindness (cCSNB) is an incurable inherited retinal disorder characterized by an ON-bipolar cell (ON-BC) defect. GRM6 mutations are the third most prevalent cause ...

Relationship between Axial Length and Levels of TGF- in the Aqueous Humor and Plasma of Myopic Patients.

Mar 18, 2021

To investigate the levels of transforming growth factor- (TGF-) in human aqueous humor (AH) and plasma (PL) of patients with myopia, and verify whether there is an association between these levels and...

Bardet-Biedl syndrome-7 () shows treatment potential and a cone-rod dystrophy phenotype that recapitulates the non-human primate model.

Mar 18, 2021

: To provide a detailed ophthalmic phenotype of two male patients with Bardet-Biedl Syndrome (BBS) due to mutations in the gene: Two brothers ages 26 (Patient 1, P1) and 23 (P2) underwent comprehensi...

The Clouclip, a wearable device for measuring near-work and outdoor time: validation and comparison of objective measures with questionnaire estimates.

Mar 18, 2021

To validate a novel wearable device that can measure both viewing distance and light exposure, Clouclip, and compare questionnaire estimates regarding near-work and outdoor time with the objective mea...

Repeatability of Non-invasive Keratograph Break-Up Time measurements obtained using Oculus Keratograph 5M.

Mar 18, 2021

The aim of this study is to assess the intraexaminer repeatability of Non-invasive Keratograph Break-Up Time (NIKBUT) obtained using the Oculus Keratograph 5M (K5M), given its relevance as a homeostas...

Overview of Ocular Side Effect of Selinexor.

Mar 18, 2021

The aim of this review is to elucidate the type and frequency of ocular adverse events associated with selinexor with a goal to quantify the occurrence of these events in our investigator-initiated tr...

Exploring the human lacrimal gland using organoids and single-cell sequencing.

Mar 18, 2021

The lacrimal gland is essential for lubrication and protection of the eye. Disruption of lacrimal fluid production, composition, or release results in dry eye, causing discomfort and damage to the ocu...

Evaluating the Viability of a Smartphone-Based Annotation Tool for Faster and Accurate Image Labelling for Artificial Intelligence in Diabetic Retinopathy.

Mar 18, 2021

Deep Learning (DL) and Artificial Intelligence (AI) have become widespread due to the advanced technologies and availability of digital data. Supervised learning algorithms have shown human-level perf...

Injury Related to Fall and Its Predictors among Medically Diagnosed Adults with Visual Impairment in Ethiopia: An Observational Cross-Sectional Study.

Mar 18, 2021

Fall-related injury is the common cause of unintentional injury and premature death among people with visual impairment. So far, the knowledge about fall-related injuries among medically diagnosed vis...

Diabetic Macular Edema Treatment with Bevacizumab Does Not Depend on the Retinal Nonperfusion Presence.

Mar 18, 2021

This study evaluated the relationship between the retinal nonperfusion area (NPA) presence and the effectiveness of bevacizumab treatment (IVB) in patients with diabetic macular edema (DME). It also t...

[Treatment of vascularized high-risk eyes with a Boston keratoprosthesis].

Mar 18, 2021

In severely compromised and vascularized high-risk eyes, the Boston keratoprosthesis procedure is often the last treatment option. The transparency of the optics is not impaired by endothelial immune ...

Aetiology and clinical characteristics of uveitic glaucoma in Turkish patients.

Mar 18, 2021

To investigate the types, frequency and clinical profiles of uveitic glaucoma seen at a tertiary care center and also to have an idea about the distribution of uveitic glaucoma types in Turkish popula...

Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure and improves retinal ganglion cells function in glaucoma.

Mar 18, 2021

Glaucoma is a progressive optic neuropathy associated with damage to retinal ganglion cells (RGCs) and disrupted circadian rhythms. Melatonin is a promising substance to ameliorate glaucoma-associated...

The relationship between education levels, lifestyle, and religion regarding the prevalence of myopia in Israel.

Mar 18, 2021

The ultra-Orthodox Jewish community has a unique lifestyle including minimal outdoor activity and intense, prolonged nearby work, beginning at a very young age. Their prevalence of myopia is extremely...

Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China.

Mar 15, 2021

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly due in large part to age-dependent atrophy of retinal pigment epithelium (RPE) cells. RPE cells form a monolayer...

Automatic Staging for Retinopathy of Prematurity with Deep Feature Fusion and Ordinal Classification Strategy.

Mar 15, 2021

Retinopathy of prematurity (ROP) is a retinal disease which frequently occurs in premature babies with low birth weight and is considered as one of the major preventable causes of childhood blindness....

Extending the phenotypic spectrum of PRPF8, PRPH2, RP1 and RPGR, and the genotypic spectrum of early-onset severe retinal dystrophy.

Mar 15, 2021

To present the detailed retinal phenotype of patients with Leber Congenital Amaurosis/Early-Onset Severe Retinal Dystrophy (LCA/EOSRD) caused by sequence variants in four genes, either not (n = 1)...

Tree shrews do not maintain emmetropia in initially-focused narrow-band cyan light.

Mar 15, 2021

We asked if emmetropia, achieved in broadband colony lighting, is maintained in narrow-band cyan light that is well focused in the emmetropic eye, but does not allow for guidance from longitudinal chr...

Variants in FLRT3 and SLC35E2B identified using exome sequencing in seven high myopia families from Central Europe.

Mar 15, 2021

High myopia (HM) is an eye disorder with both environmental and genetic factors involved. Many genetic factors responsible for HM were recognized worldwide, but little is known about genetic variants ...

Progression of myopia in children and teenagers: a nationwide longitudinal study.

Mar 15, 2021

Data on myopia prevalence and progression in European children are sparse. The aim of this work was to evaluate the progression of myopia in children and teenagers in a large prospective study.A prosp...

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