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Ophthalmology General

Hyperglycemia-induced severe mitochondrial bioenergetic deficit of lacrimal gland contributes to the early onset of dry eye in diabetic mice.

Mar 15, 2021

Dry eye and diabetic keratopathy represent the major diabetic complications in ocular surface. Here we found that diabetic mice exhibited the early onset of reduced tear secretion and lacrimal gland w...

The Effect of Upper Eyelid Muller Muscle Conjunctival Resection Surgery on Lower Eyelid Position.

Mar 15, 2021

: To examine whether Müller's-muscle-conjunctival-resection (MMCR) changes the position of the lower eyelid.: Retrospective controlled-cohort study. All patients who underwent MMCR (study group) or b...

A Phase II, Multicenter, Randomized, Placebo-Controlled, Double-Masked Trial of a Topical Estradiol Ophthalmic Formulation in Postmenopausal Women with Moderate-to-Severe Dry Eye Disease.

Mar 15, 2021

Dry eye disease (DED) is a multifactorial disorder of the ocular surface. The current phase II study was performed to assess the safety and dose regimen of a recently developed topical estradiol form...

miR-126 Mimic Counteracts the Increased Secretion of VEGF-A Induced by High Glucose in ARPE-19 Cells.

Mar 15, 2021

Vascular endothelial growth factor-A (VEGF-A) has a pathologic role in microvascular diabetic complication, such as diabetic retinopathy (DR). miR-126 plays an important role in vascular development a...

Intracystic hyperreflective material in centre-involving diabetic macular oedema.

Mar 15, 2021

To report evolution and predictive value of intracystic hyperreflective material (ICHRM) on optical coherence tomography (OCT) in centre-involving diabetic macular oedema (CI-DME).Demographic and OCT ...

Deep learning-based detection and stage grading for optimising diagnosis of diabetic retinopathy.

Mar 15, 2021

To establish an automated method for identifying referable diabetic retinopathy (DR), defined as moderate nonproliferative DR and above, using deep learning-based lesion detection and stage grading.A ...

Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma.

Mar 15, 2021

We examined responsiveness to ripasudil as a potential factor for predicting the effect of selective laser trabeculoplasty (SLT) when performed for primary open-angle glaucoma (POAG). A total of 70 ey...

Characteristics of Gln368Ter Myocilin variant and influence of polygenic risk on glaucoma penetrance in the UK Biobank.

Mar 15, 2021

MYOC (myocilin) mutations account for 3-5% of primary open angle glaucoma (POAG). We aimed to understand the true population-wide penetrance and characteristics of glaucoma among individuals with the ...

Photocoagulation for retinal vein occlusion.

Mar 15, 2021

The role of photocoagulation in retinal vein occlusion (RVO) has been studied since 1974. The most serious complications of central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRV...

Successful Implementation of Femtosecond Laser-Assisted Cataract Surgery: A Real-World Economic Analysis.

Mar 15, 2021

To calculate the minimum number of Femtosecond laser-assisted cataract surgery (FLACS) procedures required per month to pay off the fixed investment cost over 5 years to achieve break-even.A rural oph...

Patient Harm due to Diagnostic Error of Neuro-Ophthalmologic Conditions.

Mar 15, 2021

To prospectively examine diagnostic error of neuro-ophthalmic conditions and resultant harm at multiple sites.Prospective cross-sectional study.496 consecutive adult new patients seen at three univers...

A multi-scale convolutional neural network with context for joint segmentation of optic disc and cup.

Mar 11, 2021

Glaucoma is the leading cause of irreversible blindness. For glaucoma screening, the cup to disc ratio (CDR) is a significant indicator, whose calculation relies on the segmentation of optic disc(OD) ...

A novel missense mutation in the HSF4 gene of giant pandas with senile congenital cataracts.

Mar 11, 2021

Cataracts are a common cause of visual impairment and blindness in mammals. They are usually associated with aging, but approximately one third of cases have a significant genetic component. Cataracts...

Association between greater residential greenness and decreased risk of preschool myopia and astigmatism.

Mar 11, 2021

Rapid urbanization has led to reduced greenness in many areas, this has been linked to adverse health outcomes. The aim was to determine the association between residential greenness experienced durin...

Emmetropic, But Not Myopic Human Eyes Distinguish Positive Defocus From Calculated Blur.

Mar 11, 2021

Defocus blur imposed by positive lenses can induce hyperopia, whereas blur imposed by diffusers induces deprivation myopia. It is unclear whether the retina can distinguish between both conditions whe...

Flow pattern and perforating vessels in three different phases of myopic choroidal neovascularization seen by swept-source optical coherence tomography angiography.

Mar 11, 2021

To compare the choroidal neovascularization (CNV) flow patterns and the relationship between perforating vessels (PVs) and CNV in the three different stages of networks in myopic CNV (mCNV) using swep...

Corneal sub-basal nerve plexus assessment and its association with phenotypic features and lymphocyte subsets in Sjögren's Syndrome.

Mar 11, 2021

To assess and compare corneal sub-basal nerve plexus morphology with circulating lymphocyte subsets, immunologic status and disease activity in Sjögren syndrome (SjS) patients.Fifty-five SjS patients...

Inhibitory effect of host ocular microenvironmental factors on chlorhexidine digluconate activity.

Mar 11, 2021

spp. are free-living protozoan that cause a serious human eye disease called keratitis (AK). Several new and effective medical therapy for AK patients remains highly debated and therefore, CHG is st...

An overview of optometrists' diabetic retinopathy practice patterns - a cross-sectional survey.

Mar 11, 2021

Contemporary eye care increasingly recommends the use of advanced retinal imaging technology. Anecdotal evidence suggests that this equipment is widely available in primary eye care settings; however,...

Reproducing diabetic retinopathy features using newly developed human induced-pluripotent stem cell-derived retinal Müller glial cells.

Mar 11, 2021

Muller glial cells (MGCs) are responsible for the homeostatic and metabolic support of the retina. Despite the importance of MGCs in retinal disorders, reliable and accessible human cell sources to be...

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