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Ophthalmology General

Melatonin exerts protective effects on diabetic retinopathy via inhibition of Wnt/β-catenin pathway as revealed by quantitative proteomics.

Mar 01, 2021

Diabetic retinopathy (DR), the most common ocular complication resulting from diabetes in working-age adults, causes vision impairment and even blindness because of microvascular damage to the retina....

mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy.

Mar 01, 2021

Neurodegeneration, an early event in the pathogenesis of diabetic retinopathy (DR), precedes clinically detectable microvascular damage. Autophagy dysregulation is considered a potential cause of neur...

Long-term HbA1c variability and the development and progression of diabetic retinopathy in subjects with type 2 diabetes.

Mar 01, 2021

This study aimed to investigate whether long-term HbA1c variability is associated with the development and progression of diabetic retinopathy (DR) in subjects with type 2 diabetes. We retrospectively...

Fluocinolone acetonide vitreous insert for chronic diabetic macular oedema: a systematic review with meta-analysis of real-world experience.

Mar 01, 2021

We conducted a meta-analysis of real-world studies on the 0.19 mg Fluocinolone Acetonide (FAc) intravitreal implant for chronic diabetic macular oedema (DMO), comparing these findings with the Fluoci...

Predictive factors of radio-induced complications in 194 eyes undergoing gamma knife radiosurgery for uveal melanoma.

Mar 01, 2021

To report the factors predictive of radio-induced complications (i.e. radiation retinopathy [RR], radiation papillopathy [RP] and neovascular glaucoma [NVG]) in uveal melanoma (UM) patients undergoing...

Parenchymal brain injuries in abusive head trauma.

Mar 01, 2021

The consequences of abusive head trauma (AHT) can be devastating for both the individual child and for wider society. Death is undoubtedly a very real possibility, but even for those children who surv...

OCT Angiography for the Diagnosis of Glaucoma: A Report by the American Academy of Ophthalmology.

Mar 01, 2021

To review the current published literature on the use of OCT angiography (OCTA) to help detect changes associated with the diagnosis of primary open-angle glaucoma.Searches of the peer-reviewed litera...

Can the Three-Dimensional Heads-Up Display Improve Ergonomics, Surgical Performance, and Ophthalmology Training Compared to Conventional Microscopy?

Mar 01, 2021

To explore ophthalmic surgeons' opinions regarding three-dimensional heads-up display (3D HUD) use and investigate musculoskeletal (MSK) complaints among ophthalmologists.Physicians were invited to co...

Surgical Outcomes among Focused versus Diversified Cataract Surgeons.

Mar 01, 2021

Narrowly focused surgical practice has become increasingly common in ophthalmology and may have an effect on surgical outcomes. Previous research evaluating the influence of surgical focus on cataract...

Elevated apolipoprotein A1 and HDL cholesterol associated with age-related macular degeneration: two population cohorts.

Feb 18, 2021

To enable prevention and treatment of age-related macular degeneration(AMD), understanding risk factors for AMD is important.We tested the hypotheses that elevated plasma apolipoprotein A1 and high-de...

A novel proline substitution (Arg201Pro) in alpha helix 8 of TMEM98 causes autosomal dominant nanophthalmos-4, closed angle glaucoma and attenuated visual acuity.

Feb 18, 2021

Nanophthalmos-4 is a rare autosomal dominant disorder caused by two known variations in TMEM98. An Austrian Caucasian pedigree was identified suffering from nanophthalmos and late onset angle-closure ...

Refractive Error Prevalence among School Children in Dadeldhura District of Nepal.

Feb 18, 2021

Background Uncorrected refractive error is the major cause of visual impairment worldwide. There is no data on refractive error prevalence among school children in hilly region of Far West Nepal. Obje...

Changes in ocular surface and Meibomian gland after penetrating Keratoplasty.

Feb 18, 2021

To acquire desirable outcomes of penetrating keratoplasty (PKP), various factors affecting graft survival, visual function, and subjective symptom should be considered. As ocular surface and meibomian...

Elevated apolipoprotein A1 and HDL cholesterol associated with age-related macular degeneration: two population cohorts.

Feb 18, 2021

To enable prevention and treatment of age-related macular degeneration(AMD), understanding risk factors for AMD is important.We tested the hypotheses that elevated plasma apolipoprotein A1 and high-de...

Cost Analysis of Routine Vitrectomy Surgery.

Feb 18, 2021

To use electronic health record (EHR) time logs to calculate the complete cost profile of routine pars plana vitrectomy surgery DESIGN: Economic analysis.Patients undergoing elective vitrectomy proced...

Cost Analysis of Routine Vitrectomy Surgery.

Feb 18, 2021

To use electronic health record (EHR) time logs to calculate the complete cost profile of routine pars plana vitrectomy surgery DESIGN: Economic analysis.Patients undergoing elective vitrectomy proced...

Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization.

Feb 18, 2021

Age-related macular degeneration (AMD) represents the most common cause of blindness in the elderly in the Western world. An impairment of the outer blood-retina barrier and a localized inflammatory m...

Identification of additional outer segment targeting signals in zebrafish rod opsin.

Feb 18, 2021

In vertebrate photoreceptors, opsins are highly concentrated in a morphologically distinct ciliary compartment known as the outer segment (OS). Opsin is synthesized in the cell body and transported to...

Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort.

Feb 18, 2021

Refractive errors, particularly myopia, are common and a leading cause of blindness. This study aimed to explore associations between medications and refractive error in an aging adult cohort and to d...

Higher HbA1c may reduce axial length elongation in myopic children: a comparison cohort study.

Feb 18, 2021

To compare the annual axial length (AL) changes in myopic children with type 1 diabetes mellitus (T1DM) and those without diabetes.There are two groups of myopic children in this retrospective cohort ...

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