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Orthopedics General

An SNX10-dependent mechanism downregulates fusion between mature osteoclasts.

May 13, 2021

Homozygosity for the R51Q mutation in sorting nexin 10 (SNX10) inactivates osteoclasts (OCLs) and induces autosomal recessive osteopetrosis in humans and in mice. We show here that the fusion of wild-...

Risk Factors and Clinical Characteristics of Metabolic Bone Disease of Prematurity.

May 13, 2021

 The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birthweig...

Acute Response of Sclerostin to Whole-body Vibration with Blood Flow Restriction.

May 13, 2021

Blood flow restriction may augment the skeletal response to whole-body vibration. This study used a randomised, crossover design to investigate the acute response of serum sclerostin and bone turnover...

Dietary patterns and hip fracture in the Adventist Health Study 2: combined vitamin D and calcium supplementation mitigate increased hip fracture risk among vegans.

May 10, 2021

Concerns regarding the adequacy of vegetarian diets with respect to fracture risk continue.We aimed to explore the influence of 5 previously defined dietary patterns on hip fracture risk and whether t...

Pancreaticoduodenectomy for hepatic portal lymph node metastasis after hepatic resection for hepatocellular carcinoma: A clinical case report.

May 10, 2021

In 2018, Hepatocellular carcinoma (HCC) was predicted to be the sixth most commonly diagnosed cancer. Extra-hepatic metastasis due to HCC is a poor prognostic factor, depending on the stage of the dis...

Estrogen receptor α in mature osteoblasts regulates the late stage of bone regeneration.

May 10, 2021

Estrogen deficiency impairs fracture healing and homeostasis of bone tissue. OVX-induced estrogen deficiency in mice attenuates fracture healing and changes the expression ratio of estrogen receptor (...

Use of a Double Reverse Traction Repositor versus a Traction Table for the Treatment of Intertrochanteric Femur Fractures: A Comparative Study.

May 06, 2021

The aim of the present study was to compare the clinical results for unstable femoral intertrochanteric fractures treated with a double reverse traction repositor (DRTR) and those treated using a trac...

Anatomical Location of Initial and Repeat Mandible Fractures: A 5-Year, Multi-Institution Retrospective Study.

May 06, 2021

The purpose of the present study was to investigate new fracture patterns resulting from low velocity mechanisms in subjects who had previously fractured their mandible and had been treated with open ...

The association of Spondylitis and Aortic Aneurysm Disease.

May 06, 2021

The aim of this study is to assess any relation between spondylitis and aortic aneurysmal disease by reviewing the current literature.A systematic search was undertaken using MEDLINE, EMBASE and CENTR...

Comprehensive Interventions Including Vitamin D Effectively Reduce the Risk of Falls in Elderly Osteoporotic Patients.

May 06, 2021

To evaluate the effects of different intervention measures to prevent falls in elderly osteoporotic patients.A randomized controlled trial was conducted in our outpatient ward from August 2014 to Sept...

Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

May 06, 2021

The pioneer transcription factor (TF) PU.1 controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing nonpioneer TFs to enter otherwise inaccessible genomic sites. PU.1 de...

IFNλ Therapy Prevents Severe Gastrointestinal Graft-versus-Host Disease.

May 06, 2021

Immunopathology and intestinal stem cell (ISC) loss in the gastrointestinal (GI) tract is the prima-facie manifestation of graft-versus-host disease (GVHD) and is responsible for significant mortality...

Vertebral multiple myeloma with pathological fracture: the most common etiology for emergency spine surgery in patients with no cancer diagnosis on admission.

May 03, 2021

Vertebral compression fractures are common in multiple myeloma (MM). Modern treatment paradigms place emphasis on treatment with radiation, with surgery reserved for cases involving frank instability ...

Interhospital transfer status for spinal metastasis patients in the United States is associated with more severe clinical presentations and higher rates of inpatient complications.

May 03, 2021

In patients with metastatic spinal disease (MSD), interhospital transfer can potentially impact clinical outcomes as the possible benefits of transferring a patient to a higher level of care must be w...

Single-center outcomes for percutaneous pedicle screw fixation in metastatic spinal lesions: can spontaneous facet fusion occur?

May 03, 2021

Survival of cancer patients continues to improve with systemic treatment advancements, leading to an increase in cancer-related complications such as pathological spinal fractures. In this study, the ...

Factors associated with adjacent-level tumor progression in patients receiving surgery followed by radiosurgery for metastatic epidural spinal cord compression.

May 03, 2021

Separation surgery followed by spine stereotactic radiosurgery (SSRS) has been shown to achieve favorable rates of local tumor control and patient-reported outcomes in patients with metastatic epidura...

Posterior vertebral column resection as a safe procedure leading to solid bone fusion in metastatic epidural spinal cord compression.

May 03, 2021

Cancer is one of the leading causes of death and greatly decreases a patient's quality of life. Vertebral metastases often lead to epidural spinal cord compression (ESCC) requiring surgical therapy. I...

Macroscopic anatomy, radiography and computed tomography of normal paranasal sinuses of the adult one-humped dromedary (Camelus dromedarius).

May 03, 2021

In order to improve the current knowledge of the topography and the anatomy of the paranasal sinuses of the one-humped dromedary (Camelus dromedarius), we applied both conventional and advanced imagin...

Hydrochemical changes of a spring due to the May 30, 2014 Ms 6.1 Yingjiang earthquake, southwest China.

Apr 29, 2021

Groundwater chemistry can be affected by and related to earthquakes, thus it is crucial to understand the hydrochemical changes and associated processes caused by earthquakes for post-seismic groundwa...

Quantifying Lumbar Movement Patterns of Allied Health Professionals in an Australian Health Care Facility.

Apr 29, 2021

Health professionals responsible for return to work plans have little data about allied health movement to guide recommendations following lower back injury. This study aimed to quantify the lumbar mo...

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