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Orthopedics General

Efficacy of conservative therapy in older people with nonspecific low back pain: A systematic review with meta-analysis and GRADE recommendations.

Jul 20, 2020

This systematic review aimed to investigate the effectiveness of conservative therapy in older people with nonspecific low back pain.Searches were conducted on Medline, Amed, Embase, Cochrane, Psycinf...

Prognostic value of different metastatic sites for patients with FIGO stage IVB endometrial cancer after surgery: A SEER database analysis.

Jul 20, 2020

This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) st...

Technical note: Efficient and accurate MRI-only based treatment planning of the prostate using bulk density assignment through atlas-based segmentation.

Jul 20, 2020

This study investigates the dosimetric accuracy as well as the robustness of a bulk density assignment approach to MRI-only based treatment planning of the prostate, with bulk density regions automati...

UPLC-MS metabolomics method provides valuable insights into the effect and underlying mechanisms of Rhizoma Drynariae protecting osteoporosis.

Jul 20, 2020

Osteoporosis (OP) is a metabolic bone disease in which that volume of bone tissue per unit volume decrease, which is a common disease disturbing the elderly or postmenopausal women. Rhizoma Drynariae ...

Clavicle Non-Union: Plate and Graft Type Do Not Affect Healing Rates - A Single Surgeon Experience With 71 Cases.

Jul 16, 2020

Clavicle non-unions often result after nonoperative treatment for the acute fracture. Those that require >1 surgical procedure in order for a nonunion to heal are termed recalcitrant. The aims of t...

Risk factors for hardware removal following operative treatment of middle and distal third clavicle fractures.

Jul 16, 2020

The incidence of hardware removal (HWR) after operative fixation of clavicle fractures varies widely. Risk factors related to HWR remain incompletely understood. The aim of this study was to evaluate ...

Motion-Onset Visual Potentials Evoked in a Sport-Specific Visuomotor Reaction Task.

Jul 16, 2020

Although neural visual processes play a crucial role in sport, experiments have been restricted to laboratory conditions lacking ecological validity. Therefore, this study examined the feasibility of ...

Rationale for Definitive Mini Dental Implant Treatment.

Jul 16, 2020

Mini dental implants can be used to support crowns and partial and complete dentures in compromised edentulous sites. Lack of bone width or site length may be treated with mini implants. Mini implants...

Classification, Categorization, and Algorithms for Articular Cartilage Defects.

Jul 16, 2020

There is a critical unmet need in the clinical implementation of valid preventative and therapeutic strategies for patients with articular cartilage pathology based on the significant gap in understan...

Estimation of [177Lu]PSMA-617 tumor uptake based on voxel-wise 3D Monte Carlo tumor dosimetry in patients with metastasized castration resistant prostate cancer.

Jul 16, 2020

 Patients with advanced prostate cancer are suitable candidates for [Lu]PSMA-617 therapy. Integrated SPECT/CT systems have the potential to improve the accuracy of patient-specific tumor dosimetry. ...

Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017.

Jul 13, 2020

Musculoskeletal diseases (MSDs) are the leading cause of disability and facing them demands updated reports on their burden for efficient policymaking. We showed Iran had the highest female-to-male ra...

Effect of Botulinum Toxin Type A on Mandibular Fracture Healing: An Experimental Study in Rabbits.

Jul 13, 2020

The effect of botulinum toxin type A (BTX-A) on fracture healing of the long bones is controversial, and no controlled clinical or experimental study has investigated the effect of BTX-A on mandibular...

Patient Preferences for Osteoarthritis Pain and Chronic Low Back Pain Treatments in the United States: A Discrete-Choice Experiment.

Jul 13, 2020

To quantify preferences for attributes of potential analgesic treatments for moderate-to-severe pain associated with osteoarthritis (OA) and/or chronic low back pain (CLBP) as relevant to injectable n...

Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.

Jul 13, 2020

Osteoarthritis (OA) is a common degenerative disease that affects the musculoskeletal structure of the whole joint, which is characterized by progressive destruction of both articular cartilage and su...

The Response of Gingiva Monolayer, Spheroid and ex vivo Tissue Cultures to Collagen Membranes and Bone Substitute.

Jul 13, 2020

Collagen membranes and bone substitute are popular biomaterials in guided tissue regeneration for treatment of traumatized or diseased periodontal tissue. Development of these biomaterials starts in m...

MMP13 and TIMP1 are functional markers for two different potential modes of action by mesenchymal stem/stromal cells when treating osteoarthritis.

Jul 13, 2020

Mesenchymal stem cells (MSCs) have been investigated as a potential injectable therapy for the treatment of knee osteoarthritis, with some evidence of success in preliminary human trials. However, opt...

A rare case of intramedullary spinal dermoid cyst in adult: A case report.

Jul 09, 2020

Intramedullary spine dermoid cysts are rare and benign tumors that occur mainly due to the defective closure of the neural tube during the development process. They are slow-growing tumor that manifes...

Spinal epidural lipomatosis with osteoporotic vertebral fracture presenting as acute thoracic myelopathy in a 33-year-old man with Cushing's disease.

Jul 09, 2020

Steroid-related spinal epidural lipomatosis (SEL) is a well-known condition most commonly encountered in patients taking chronic steroid medications. Endogenous Cushing's syndrome is a rare cause of S...

Comfrey (Symphytum spp.) as an alternative field crop contributing to closed agricultural cycles in chicken feeding.

Jul 09, 2020

Local cultivars of comfrey (Symphytum spp.) have been used to cover protein and mineral requirements of farm animals in low-input systems. Due to its known health-promoting (e.g. allantoin), but also ...

Bone interface modulates drug resistance in breast cancer bone metastasis.

Jul 09, 2020

Metastatic breast cancer cells on arriving at bone site interact with the bone cells to influence their growth, proliferation, and chemoresistance. There are currently no effective therapeutics availa...

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