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Orthopedics General

β-Elemonic acid inhibits the growth of human Osteosarcoma through endoplasmic reticulum (ER) stress-mediated PERK/eIF2α/ATF4/CHOP activation and Wnt/β-catenin signal suppression.

Mar 02, 2020

Osteosarcoma (OS) is a significant threat to the lives of children and young adults. Although neoadjuvant chemotherapy is the first choice of treatment for OS, it is limited by serious side-effects an...

Prevent action of magnoflorine with hyaluronic acid gel from cartilage degeneration in anterior cruciate ligament transection induced osteoarthritis.

Mar 02, 2020

According to the Chinese medicine, magnoflorine exerted significant anti-inflammatory effects and potentially promoted synthesis of proteoglycans in chondrocytes to reverse the progression of rheumato...

Case Study: Resumption of Eumenorrhea in Parallel With High Training Load After 4 Years of Menstrual Dysfunction: A 5-Year Follow-Up of an Elite Female Cyclist.

Feb 28, 2020

The female athlete triad is a condition where low energy availability is typically observed together with menstrual dysfunction and/or low bone mineral density. How this condition affects maximal work...

The Temporal Ordering of Motivation and Self-Control: A Cross-Lagged Effects Model.

Feb 28, 2020

Mechanisms leading to cognitive energy depletion in performance settings such as high-level sports highlight likely associations between individuals' self-control capacity and their motivation. Invest...

Epidemiology of Pediatric Upper Extremity Fractures in Tertiary Care Center in Switzerland.

Feb 28, 2020

Fractures in children are common and account for 10% to 25% of injuries in children with considerable effects on activity restriction and subsequent high socioeconomically impact. Eighty percent of al...

Subgaleal Hemorrhage Secondary to Child Physical Abuse in a 4-Year-Old Boy.

Feb 28, 2020

Subgaleal hemorrhage is commonly described in the neonatal population but is a rare injury in young children and adolescents. Though infrequently seen, it can follow blunt head trauma or hair pulling....

New Developments in Diagnosis, Prognostication, and Treatment of Advanced Systemic Mastocytosis.

Feb 28, 2020

Systemic mastocytosis (SM) has greatly benefited from the broad application of precision medicine techniques to hematolymphoid neoplasms. Sensitive detection of the recurrent KIT D816V mutation and us...

Avulsion Injuries of the Pelvis and Hip.

Feb 28, 2020

 Avulsion injuries of the pelvis and hip region are typical injuries in adolescent athletes but can be found in adults as well. Typical sites for avulsion injuries include the origin/insertion of te...

Association of clinical severity with FANCB variant type in Fanconi anemia.

Feb 28, 2020

Fanconi anemia (FA) is the most common genetic cause of bone marrow failure, and is caused by inherited pathogenic variants in any of 22 genes. Of these, only FANCB is X-linked. We describe a cohort o...

Spatiotemporal signal detection using continuous shrinkage priors.

Feb 28, 2020

Periodontal disease (PD) is a chronic inflammatory disease that affects the gum tissue and bone supporting the teeth. Although tooth-site level PD progression is believed to be spatio-temporally refer...

ZNF687 mutations in an extended cohort of neoplastic transformations in Paget's disease of bone: implication for clinical pathology.

Feb 28, 2020

Neoplastic transformation is a rare but serious complication of Paget's disease of bone (PDB), occurring in fewer than 1% of individuals with polyostotic disease. Their prognosis is poor, with less th...

Pain Education With Therapeutic Exercise in Chronic Nonspecific Low Back Pain Rehabilitation: A Critically Appraised Topic.

Feb 28, 2020

Clinical Scenario: Low back pain is widely prevalent in the general population as well as in athletes. Therapeutic exercise is a low-risk and effective treatment option for chronic pain that can be ut...

Consistency between anticholinergic burden scales in the elderly with fractures.

Feb 25, 2020

Falls and bone fractures are important causes of morbidity and mortality in the elderly. The objective of this study was to identify the degree of consistency between the anticholinergic scales used f...

Favorable skeletal benefit/risk of long-term denosumab therapy: A virtual-twin analysis of fractures prevented relative to skeletal safety events observed.

Feb 25, 2020

Antiresorptive therapies reduce fracture risk; however, long-term bone turnover inhibition may raise concerns about rare, but serious, skeletal adverse events-atypical femoral fracture (AFF) and osteo...

Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study.

Feb 25, 2020

To investigate the effectiveness of the T-score values provided by Radiofrequency Echographic Multi Spectrometry (REMS) in the identification of patients at risk for incident osteoporotic fractures.A ...

Association between lower back pain and lower extremity pain among young volleyball players: A cross-sectional study.

Feb 25, 2020

Lower back pain (LBP), as well as lower extremity injuries, are major problems among young volleyball players. Nevertheless, only few studies have focused on the relationship between lower extremity i...

Investigation of the Effect of Secreted Factors from Mesenchymal Stem Cells on Disc Cells from Degenerated Discs.

Feb 25, 2020

Low back pain is experienced by a large number of people in western countries and may be caused and influenced by many different pathologies and psychosocial factors including disc degeneration. Disc ...

Accelerating bone defects healing in calvarial defect model using 3D cultured bone marrow-derived mesenchymal stem cells on demineralized bone particle scaffold.

Feb 18, 2020

Bone defects are usually difficult to be regenerated due to pathological states or the size of the injury. Researchers are focusing on tissue engineering approaches in order to drive the regenerative ...

Histone Hyperacetylation Mediates Enhanced IL-1β Production in LPS/IFN-γ stimulated Macrophages.

Feb 18, 2020

Under the condition of LPS/IFN-γ activation, macrophage metabolism is conversed from oxidative phosphorylation to glycolysis. In the present work, we analyzed whether glycolysis could affect IL-1β e...

Malignant struma ovarii with a robust response to radioactive iodine.

Feb 18, 2020

Struma ovarii is a rare, usually benign ovarian tumour with malignancy occurring in 3000 µg/L following recombinant TSH administration prior to her first dose of I131. At 25 months following radioiod...

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