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Orthopedics General

Inhibition of PTP1B Phosphorylation Enhances Early Adhesion of Mesenchymal Stem Cells to Facilitate Fabrication of Tissue-Engineered Bone.

Feb 18, 2020

Enhancement of cell-matrix adhesion is preferable and crucial in various fields of tissue engineering. Integrins are important receptors that facilitate cell-matrix adhesion, mediated by intracellular...

Lumbar intervertebral disc characterization through quantitative MRI analysis: An automatic voxel-based relaxometry approach.

Feb 17, 2020

To develop an automated pipeline based on convolutional neural networks to segment lumbar intervertebral discs and characterize their biochemical composition using voxel-based relaxometry, and establi...

LncRNA KCNQ1OT1 accelerates fracture healing via modulating miR-701-3p/FGFR3 axis.

Feb 17, 2020

Emerging evidence highlights the role of the long noncoding RNA (lncRNA) KCNQ1OT1 in fracture healing. Osteoblast proliferation, migration, and survival are pivotal during this process. In this study,...

Pulsed Radiofrequency Treatment for Bertolotti's Syndrome Presenting with Low Back Pain: Report of Four Cases.

Feb 17, 2020

Pulsed radiofrequency (PRF) has been used successfully to treat myriad types of chronic pain, including spinal radicular pain and that associated with facet arthropathy. Although there are a few repor...

Oxytocin modulates intrinsic neural activity in patients with chronic low back pain.

Feb 17, 2020

Modulation of pain perception by oxytocin (OXT) has attracted increased scientific and clinical interest. Neural mechanisms underlying these effects are poorly understood. In this study, we aimed to i...

Use of portfolios in teaching communication skills and professionalism for Portuguese-speaking medical students.

Feb 17, 2020

This study aimed to analyse the effect of a portfolio with three activities fostering students' reflection, self-efficacy and teaching of communication skills and professionalism.A cross-sectional stu...

The Wickerhamiella/Starmerella clade - a treasure trove for the study of the evolution of yeast metabolism.

Feb 17, 2020

The Wickerhamiella and Starmerella genera form a clade (W/S clade) that branches close to Yarrowia lipolytica in the Saccharomycotina species tree. It comprises approximately 90 recognized species and...

Conservation and expansion of a necrosis-inducing small secreted protein family from host-variable phytopathogens of the Sclerotiniaceae.

Feb 17, 2020

Fungal effector proteins facilitate host-plant colonization and have generally been characterized as small secreted proteins (SSPs). We classified and functionally tested SSPs from the secretomes of t...

Bioinspired oxidation in the CYP of isomers orientin and isoorientin using Salen complexes.

Feb 17, 2020

Orientin and isoorientin are C-glycosidic flavonoids, considered as markers of some plant species as Passiflora edulis var. flavicarpa Degener and reported in the literature to have pharmacological pr...

Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy.

Feb 17, 2020

Osteosarcoma (OSA) is the most common primary bone cancer in children, adolescents and dogs. Current combination surgical and chemotherapeutic treatments have increased survival. However, in recurrent...

Cyclins E1 and E2 in ER+ breast cancer: prospects as biomarkers and therapeutic targets.

Feb 17, 2020

Cyclin E1 is one the most promising biomarkers in estrogen receptor positive (ER+) breast cancer for response to the new standard of care drug class, CDK4/6 inhibitors. Because of its strong predictiv...

Is Bone Non-Union, Vertebral Deformity, or Spino-Pelvic Malalignment the Best Therapeutic Target for Amelioration of Low Back Pain after Osteoporotic Vertebral Fracture?

Feb 13, 2020

Cohort study (level 3).To identify independent risk factors for residual low back pain (LBP) following osteoporotic vertebral fracture (OVF).Non-union has been proposed as the primary cause of residua...

Traumatic Atlanto-occipital Dislocation: Analysis of 15 Survival Cases With Emphasis on Associated Upper Cervical Spine Injuries.

Feb 13, 2020

Retrospective case analyses.The aim of this study was to investigate the incidence and characteristics of associated upper cervical spine injuries in 15 survival cases of traumatic atlanto-occipital d...

Predictive Forward Dynamic Simulation of Manual Wheelchair Propulsion on a Rolling Dynamometer.

Feb 13, 2020

Research studies to understand the biomechanics of manual wheelchair propulsion often incorporate experimental data and mathematical models. This project aimed to advance this field of study by develo...

Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial.

Feb 13, 2020

Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could redu...

Long-term use of dienogest for the treatment of primary and secondary dysmenorrhea.

Feb 13, 2020

To investigate the safety and efficacy of dienogest (DNG), a progestational 19-norsteroid, administered for 52 weeks in patients with primary and secondary dysmenorrhea.A total of 147 patients with ...

Certified Nurse Midwives as Teachers of Family Medicine Residents.

Feb 13, 2020

The high quality of obstetric care provided by certified nurse midwives (CNMs) has led some to hypothesize that collaboration with CNMs may encourage more family medicine (FM) residents to subsequentl...

Unmasking Identity: Observations From a Cohort of Entering Medical Students.

Feb 13, 2020

Professional identity formation (PIF) is increasingly recognized as a core element of medical education. The use of narrative reflection is traditionally the most common means to explore PIF. We explo...

Family Medicine Journal Club: To Tweet or Not to Tweet?

Feb 13, 2020

Online journal clubs have recently become popular, but their effectiveness in promoting meaningful discussion of the evidence is unknown. We aimed to understand the learner experience of a hybrid onli...

EHR Overtime: An Analysis of Time Spent After Hours by Family Physicians.

Feb 13, 2020

Time spent in the electronic health record (EHR), away from direct patient care, is associated with physician burnout. Yet there is a lack of evidence quantifying EHR use among family physicians. The ...

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