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Orthopedics General

Comparison of 3D quantitative osteoarthritis imaging biomarkers from paired CT and MR images: data from the IMI-APPROACH study.

Jan 30, 2023

MRI bone surface area and femoral bone shape (B-score) measures have been employed as quantitative endpoints in DMOAD clinical trials. Computerized Tomography (CT) imaging is more commonly used for 3D...

Comparison of the effectiveness of different machine learning algorithms in predicting new fractures after PKP for osteoporotic vertebral compression fractures.

Jan 23, 2023

The use of machine learning has the potential to estimate the probability of a second classification event more accurately than traditional statistical methods, and few previous studies on predicting ...

A real-world study of treatment patterns among patients with osteoporotic fracture: analysis of a Japanese hospital database.

Jan 23, 2023

Health records of patients hospitalized for osteoporotic fracture were analyzed. Prior to the index hospital admission, most patients were not receiving any antiosteoporotic treatment. During the inde...

Impaction grafting of lumbar pedicle defects: a biomechanical study of a novel technique for pedicle screw revision.

Jan 23, 2023

The two most common revision options available for the management of loose pedicle screws are larger-diameter screws and cement augmentation into the vertebral body for secondary fixation. An alternat...

Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice.

Jan 23, 2023

Glucagon-like peptide-2 (GLP-2) is secreted postprandially by enteroendocrine L-cells and stimulates growth of the gut and bone. One GLP-2 analogue is approved for short bowel syndrome (SBS). To impro...

Outcome After Treatment of Distal Fibula Fractures Using One-Third Tubular Plate, Locking Compression Plate or Distal Anatomical Locking Compression Plate.

Jan 16, 2023

Surgical treatment of lateral distal fibula fractures is associated with high risk of reoperation and complications. The primary aim was to report risks of surgical site infection (SSI) and reoperatio...

Failure modes after anterior cruciate ligament reconstruction: a systematic review and meta-analysis.

Jan 16, 2023

The reason for graft failure after anterior cruciate ligament reconstruction (ACLR) is multifactorial. Controversies remain regarding the predominant factor and incidence of failure aetiology in the l...

The Integrator complex desensitizes cellular response to TGF-β/BMP signaling.

Jan 16, 2023

Maintenance of stem cells requires the concerted actions of niche-derived signals and stem cell-intrinsic factors. Although Decapentaplegic (Dpp), a Drosophila bone morphogenetic protein (BMP) molecul...

The prevalence of headshaking in horses with primary and secondary dental sinusitis and computed tomographic evidence of infraorbital canal pathology.

Jan 16, 2023

Sinusitis is a common disease of horses yet there are a limited number of reports in the literature that describe the prevalence of infraorbital canal (IOC) pathology and headshaking behaviour in hors...

Auditory rehabilitation after temporal bone fracture with cochlea implants - a case control study.

Jan 09, 2023

Temporal bone fracture can cause posttraumatic deafness. Sequelae like ossification or obliteration of the cochlea can impact the outcome of cochlea implantation. This study highlights the effect of ...

Effects of surgical factors on the outcomes of zygoma reduction malarplasty: a quantitative computed tomography study.

Jan 09, 2023

Malarplasty is widely performed for zygoma reduction. The effects of body segmentation, plate bending, and postoperative arch location on zygomatic movement have not been analyzed using computed tomog...

Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression.

Jan 02, 2023

Fibroblast activation protein (Fap) is a serine protease that degrades denatured type I collagen, α2-antiplasmin and FGF21. Fap is highly expressed in bone marrow stromal cells and functions as an os...

Effect of Abaloparatide on Bone Microarchitecture Assessed by Trabecular Bone Score in Women with Osteoporosis: Post Hoc Analysis of ACTIVE and ACTIVExtend.

Jan 02, 2023

Although bone mineral density (BMD) is a predictor of fracture, many fractures occur in women with T-scores >-2.5. Bone microarchitecture, assessed by trabecular bone score (TBS), predicts fracture...

Position Statement: Vitamin D Intake to Prevent Osteoporosis and Fracture in Adults.

Dec 19, 2022

Adequate vitamin D status is essential for bone health. New randomized controlled trials investigating the effect of vitamin D supplementation on bone health have recently been published. This positio...

Staging of newly diagnosed Ewing sarcoma: Results of bone marrow aspiration and biopsy versus (18)FDG-PET/CT imaging for bone marrow involvement.

Dec 12, 2022

Ewing sarcoma (ES) is an aggressive bone or extraosseous tumour with an unfavourable prognosis when bone marrow metastases are present at diagnosis. The gold standard diagnosis for bone marrow (BM) in...

Body Fat Percentage and the Long-term Risk of Fractures. The EPIC-Norfolk Prospective Population Cohort Study.

Dec 12, 2022

This cohort study aimed to determine the association between body fat percentage (BF%), incident fractures and calcaneal broadband ultrasound attenuation (BUA).Participants were drawn from the EPIC-No...

Adaptive Risk Modeling: Improving Risk Assessment of Geriatric Hip Fracture Patients Throughout their Hospitalization.

Dec 05, 2022

The purpose of this study was twofold: 1. To assess how adaptive modeling, accounting for development of inpatient complications, affects the predictive capacity of the risk tool to predict inpatient ...

External root resorption (ERR) and rapid maxillary expansion (RME) at post-retention stage: a comparison between tooth-borne and bone-borne RME.

Dec 05, 2022

The study aimed to compare external root resorption (ERR) three-dimensionally in subjects treated with tooth-borne (TB) versus bone-borne (BB) rapid maxillary expansion (RME). Forty subjects who recei...

External root resorption (ERR) and rapid maxillary expansion (RME) at post-retention stage: a comparison between tooth-borne and bone-borne RME.

Dec 05, 2022

The study aimed to compare external root resorption (ERR) three-dimensionally in subjects treated with tooth-borne (TB) versus bone-borne (BB) rapid maxillary expansion (RME). Forty subjects who recei...

Data-driven development of the nationwide hip fracture registry in the Netherlands.

Dec 05, 2022

Additional variables for a nationwide hip fracture registry must be carefully chosen to prevent unnecessary registry load. A registry pilot in seven hospitals resulted in recommending polypharmacy, se...

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