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Orthopedics

Knockout of NRAGE promotes autophagy related gene expression and the periodontitis process in mice.

Aug 06, 2020

Neurotrophin receptor-interacting MAGE homologue (NRAGE) plays a crucial role in the regulation of bone metabolism. The present study investigated the regulation role of NRAGE on autophagy activation ...

Extent of Hyperostotic Bone Resection in Convexity Meningioma to Achieve Pathologically Free Margins.

Aug 06, 2020

Hyperostosis in meningiomas can be present in 4.5% to 44% of cases. Radical resection should include aggressive removal of invaded bone. It is not clear however to what extent bone removal should be c...

BMP2 signalling activation enhances bone metastases of non-small cell lung cancer.

Aug 06, 2020

Distant metastases occur when non-small cell lung cancer (NSCLC) is at late stages. Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported th...

Worldwide Burden of Gout Increased From 1990 to 2017

Aug 05, 2020

WEDNESDAY, Aug. 5, 2020 (HealthDay News) -- From 1990 to 2017, the burden of gout increased across the world, according to a study published online Aug. 5 in Arthritis & Rheumatology. Saeid Safir...

Health Plans Not Implementing Prior Authorization Reforms

Aug 05, 2020

WEDNESDAY, Aug. 5, 2020 (HealthDay News) -- Physicians say prior authorization (PA) continues to interfere with patient care and can lead to adverse clinical consequences, according to the results of ...

Prevalence of osteoporosis and osteopenia diagnosed using quantitative CT in 296 consecutive lumbar fusion patients.

Aug 03, 2020

Osteoporosis is a metabolic bone disease that increases the risk for fragility fractures. Screening and diagnosis can be achieved by measuring bone mineral density (BMD) using quantitative CT tomograp...

The association between lower Hounsfield units of the upper instrumented vertebra and proximal junctional kyphosis in adult spinal deformity surgery with a minimum 2-year follow-up.

Aug 03, 2020

Patients undergoing long-segment fusions from the lower thoracic (LT) spine to the sacrum for adult spinal deformity (ASD) correction are at risk for proximal junctional kyphosis (PJK). One mechanism ...

Preoperative bone health assessment and optimization in spine surgery.

Aug 03, 2020

The purpose of this investigation was to characterize the bone health in preoperative spine surgery patients. This information will provide a framework to understand the needs and methods for providin...

Association of osteopenia and osteoporosis with higher rates of pseudarthrosis and revision surgery in adult patients undergoing single-level lumbar fusion.

Aug 03, 2020

Patients with osteopenia or osteoporosis who require surgery for symptomatic degenerative spondylolisthesis may have higher rates of postoperative pseudarthrosis and need for revision surgery than pat...

Lumbar disc height and vertebral Hounsfield units: association with interbody cage subsidence.

Aug 03, 2020

Postoperative subsidence of transforaminal lumbar interbody fusion (TLIF) cages can result in loss of lordosis and foraminal height, and potential recurrence of nerve root impingement. The objectives ...

Sex Differences in Income Vary With Proportion of Male Doctors

Aug 02, 2020

FRIDAY, July 31, 2020 (HealthDay News) -- For surgical and nonsurgical specialists, sex differences in income vary with the proportion of male physicians in a practice, according to a study published ...

Telemedicine Use Explodes During COVID-19 Pandemic

Aug 02, 2020

FRIDAY, July 31, 2020 (HealthDay News) -- The emergence of telemedicine has accelerated during the coronavirus pandemic. HD Live! sat down with Rujuta Saksena, M.D., an oncologist at Overlook Medical ...

Implementation of a multidisciplinary rehabilitation program for patients with chronic low back pain-experiences and perspectives of rehabilitation team members.

Jul 30, 2020

Low back pain is a common condition and one of the leading reasons for years of chronic disability. Rehabilitation has been shown to be effective on low back pain, because it is based on the complex a...

Assesment of the influence of global and local exercises on core stabilisation mechanisms: randomised control trial.

Jul 30, 2020

Over the last few years, various concepts of applying core stabilisation mechanisms in the formation of human motor function have come to existence. The objective of the research was to assess the inf...

Short Stature is Progressive in Patients with Heterozygous NPR2 Mutations.

Jul 30, 2020

NPR2 encodes atrial natriuretic peptide receptor B (ANPRB), a regulator of skeletal growth. Biallelic loss-of-function mutations in NPR2 result in acromesomelic dysplasia Maroteaux type (AMDM; OMIM 60...

Insulin receptor substrate-1 inhibits high-fat diet-induced obesity by browning of white adipose tissue through miR-503.

Jul 30, 2020

Genetic variation of insulin receptor substrate 1 (IRS-1) was found to modulate the insulin resistance of adipose tissues, but the underlying mechanism was not clear. To investigate how the IRS-1 was ...

Bone scan index can be a useful biomarker of survival outcomes in patients with metastatic castration-resistant prostate cancer treated with radium-223.

Jul 30, 2020

Bone metastasis of prostate cancer is associated with pain and reduced overall survival (OS). Radium-223, which is expected to reduce bone pain and prolong OS, was recently approved in Japan.The aim o...

Clinical and Psychosocial Factors Over Time Following an Acute Low Back Pain Episode.

Jul 27, 2020

Low back pain (LBP) is a prevalent condition with overwhelming healthcare costs and high disability rates. Characterization of clinical and psychosocial variables over time in patients experiencing an...

Supplementary Energy Increases Bone Formation during Arduous Military Training.

Jul 27, 2020

To investigate the effect of supplementary energy on bone formation and resorption during arduous military training in energy deficit.Thirty male soldiers completed an 8-week military combat course (m...

Trunk and Lower Extremity Movement Patterns, Stress Fracture Risk Factors, and Biomarkers of Bone Turnover in Military Trainees.

Jul 27, 2020

Military service members commonly sustain lower extremity stress fractures (SFx). How SFx risk factors influence bone metabolism is unknown. Understanding how SFx risk factors influence bone metabolis...

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