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Pain General

Influence of Future Prescribers' Personal and Clinical Experiences With Opioids on Plans to Treat Patients With Opioid Use Disorder.

Mar 12, 2020

Recreational use of opioids is a growing problem in the United States, particularly in the Midwest. Educators have called for inclusion of pain- and opioid-specific courses in health professional scho...

The impact of intravenous opioid shortages on postoperative pain control in a pediatric cardiac intensive care unit.

Mar 12, 2020

The national supply of intravenous pain medications has been restricted since 2018 due to shortages. In late 2017, the ongoing shortages combined with the increased demand for alternative formulations...

Phenotype of Innate Immune Cells in Uveitis Associated with Axial Spondyloarthritis- and Juvenile Idiopathic Arthritis-associated Uveitis.

Mar 12, 2020

: To analyze circulating immune cells in patients with anterior uveitis (AU) associated to axial spondyloarthritis (SpA), or juvenile idiopathic arthritis (JIA).: Venous blood samples were collected f...

Gender Bias and Genotype Influence on Opioid Safety Profile in Chronic Low Back Pain.

Mar 12, 2020

The use of opioids to relieve pain is a challenge because of the high variability in dose requirements and tolerance profiles. Amongst potential modulators are individual's genetic background as well ...

Pain-related behaviors associated with persistence of mechanical hyperalgesia post antigen-induced arthritis in rats.

Mar 12, 2020

Upon transient musculoskeletal diseases, some patients develop persistent pain while others recover from pain. Here we studied whether such heterogeneity also occurs in rats after recovery from unilat...

Activation of EphB receptors contributes to primary sensory neuron excitability by facilitating Ca2+ influx directly or through Src kinase-mediated NMDA receptor phosphorylation.

Mar 12, 2020

EphrinB-EphB receptor tyrosine kinases have been demonstrated to play important roles in pain processing after peripheral nerve injury. We have previously reported that ephrinB-EphB receptor signaling...

Learning mechanisms in nocebo hyperalgesia: the role of conditioning and extinction processes.

Mar 12, 2020

Nocebo hyperalgesia is a clinically relevant phenomenon and may be formed as a result of associative learning, implemented by classical conditioning. This study explored for the first time distinct no...

Individual variability and sex differences in conditioned pain modulation and the impact of resilience, and conditioning stimulus pain unpleasantness and salience.

Mar 12, 2020

Distinct pain experiences are shaped both by personal attributes and characteristics of noxious stimuli. An individual's capacity for endogenous pain inhibition (reflected by conditioned pain modulati...

Novel compound heterozygous pathogenic variants in ASCC1 in a Chinese patient with spinal muscular atrophy with congenital bone fractures 2 : Evidence supporting a "Definitive" gene-disease relationship.

Mar 12, 2020

A very limited spectrum of ASCC1 pathogenic variants had been reported in six (mostly consanguineous) families with spinal muscular atrophy with congenital bone fractures 2 [OMIM #616867] since 2016.A...

Fatal overdose prevention and experience with naloxone: A cross-sectional study from a community-based cohort of people who inject drugs in Baltimore, Maryland.

Mar 12, 2020

Overdose is a leading cause of death in the United States, especially among people who inject drugs (PWID). Improving naloxone access and carrying among PWID may offset recent increases in overdose mo...

Artificial neural network analysis of bone quality DXA parameters response to teriparatide in fractured osteoporotic patients.

Mar 12, 2020

Teriparatide is a bone-forming therapy for osteoporosis that increases bone quantity and texture, with uncertain action on bone geometry. No data are available regarding its influence on bone strain. ...

Stromal Cells in the Pathogenesis of Inflammatory Bowel Disease.

Mar 12, 2020

Up till now, research on inflammatory bowel disease [IBD] has mainly been focused on the immune cells present in the gastrointestinal tract. However, recent insights indicate that stromal cells also p...

Prevalence of extra-articular manifestations in psoriatic arthritis: a systematic review and meta-analysis.

Mar 12, 2020

To describe the prevalence of extra-articular manifestations-enthesitis, dactylitis, nail disease, uveitis and IBD-in PsA, and their impact on longitudinal disease outcomes.We searched Medline, PubMed...

Comparison of cannulated lag screws and lateral locking plate in the treatment of Schatzker type II tibial plateau fractures.

Mar 12, 2020

This study aims to compare the clinical and radiological outcomes of the two fixation methods frequently used in the treatment of Schatzker type II fractures: lag screw fixation and lateral anatomic p...

Can infection after anterior cruciate ligament surgery be prevented by inserting a Hemovac drain into graft donor site?

Mar 12, 2020

This study aims to investigate the effect of Hemovac drainage placed in graft harvesting area on preventing deep surgical site infection (SSI) and/or septic arthritis through draining the hematoma for...

Characterization of Cortisol Dysregulation in Fibromyalgia and Chronic Fatigue Syndromes: A State-Space Approach.

Mar 10, 2020

Fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS) are complicated medical disorders, with little known etiologies. The purpose of this research is to characterize FMS and CFS by studying ...

Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis.

Mar 09, 2020

To combine meta-analyses of multiple long-term outcomes in children prenatally exposed to methadone or buprenorphine through their mothers' Opioid maintenance therapy (OMT) with a systematic review of...

Pain catastrophizing as a predictor of suicidal ideation in chronic pain patients with an opiate prescription.

Mar 09, 2020

Chronic pain and opioid use are associated with increased risk for suicidal ideation and behaviors (SIB) in cross-sectional studies, particularly among individuals who catastrophize about their pain. ...

Step-Headache: A Distinct Symptom of Migraine.

Mar 09, 2020

 The diagnosis of migraine depends on various characteristics of headache with their associated constitutional symptoms such as nausea, vomiting, photophobia, and phonophobia. Relatively severe int...

Prolonged Migraine Stuttering Aura: Structural, Functional, and Video Neuroimaging Study of an Atypical Migraine Aura. A Case Report.

Mar 09, 2020

Stuttering is a disorder in the rhythm of speech characterized by an involuntary repetition, prolongation, and cessation of sounds. Neurogenic acquired stuttering is a very rare disorder which could r...

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