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Pain General

Non-celiac gluten sensitivity and chronic refractory low back pain with spondyloarthritis features.

Mar 09, 2020

To propose the hypothesis that non-celiac gluten sensitivity is associated with chronic low-back pain related to spondyloarthritis, and a gluten free diet has a therapeutic benefit in a subgroup of pa...

Methamphetamine and Opioid Cue Database (MOCD): Development and Validation.

Mar 09, 2020

Drug cue reactivity (DCR) is widely used in experimental settings for both assessment and intervention. There is no validated database of pictorial cues available for methamphetamine and opioids.360 i...

The spatio-temporal distribution of naloxone administration events in rural Ohio 2010-16.

Mar 09, 2020

In 2017, Ohio had the second highest rate of drug overdose deaths in the United States. Current opioid related epidemiologic literature has begun to uncover the environmental level influences on the o...

Botulinum neurotoxin injections for muscle-based (dystonia and spasticity) and non-muscle-based (neuropathic pain) pain disorders: a meta-analytic study.

Mar 09, 2020

Apart from the known efficacy of Botulinum Neurotoxin Type A (BoNT/A) in hyperactive striated and smooth muscles, different pain states have become potential targets of toxin effects. This present stu...

Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes.

Mar 09, 2020

Astrocytes mediate a remarkable variety of cellular functions, including gliotransmitter release. Under pathological conditions, high concentrations of the purinergic receptor agonist adenosine tripho...

Remission in psoriatic arthritis: Definition and predictors.

Mar 09, 2020

To determine the frequency of remission defined by the absence of the various disease manifestations of psoriatic arthritis (PsA) and identify predictors for remission.Patients followed at the PsA cli...

Nerve growth factor promotes ASIC1a expression via the NF-κB pathway and enhances acid-induced chondrocyte apoptosis.

Mar 09, 2020

Nerve growth factor (NGF) is a neurotrophic factor that is thought to have a broad role in the nervous system and tumors, and has recently been described as a mediator of inflammation. It is not clear...

Differential impact of psychological and psychophysical stress on low back pain in mice.

Mar 09, 2020

Low back pain (LBP) is a highly prevalent and disabling condition whose initiating factors are poorly understood. It is known that psychological and physical stress is associated with LBP but the caus...

Alcohol-aggravated episodic pain in humans with SCN11A mutation and ALDH2 polymorphism.

Mar 09, 2020

Mutations in Nav1.9 encoded by SCN11A have been associated with episodic pain, small-fiber neuropathy and congenital insensitivity to pain. In this study, we collected and characterized one Chinese fa...

Parent cognitive, behavioural, and affective factors and their relation to child pain and functioning in pediatric chronic pain: a systematic review and meta-analysis.

Mar 09, 2020

Prior studies have demonstrated that parental cognitive, behavioral and emotional factors are related to child functioning in children and adolescents with chronic pain. This is particularly important...

Non-surgical mouse model of endometriosis-associated pain that responds to clinically active drugs.

Mar 09, 2020

Endometriosis is an estrogen-dependent inflammatory disease that affects approximately 10% of women. Debilitating pelvic or abdominal pain is one of its major clinical features. Current animal models ...

Examining risk behavior and syringe coverage among people who inject drugs accessing a syringe services program: A latent class analysis.

Mar 09, 2020

Injection drug use (IDU) remains a significant public health problem. IDU has been associated closely with the opioid crisis; driving overdose, HIV, and Hepatitis C (HCV) infection nationwide. Syringe...

Autonomic nervous system and inflammation interaction in endometriosis-associated pain.

Mar 09, 2020

Endometriosis is a chronic inflammatory disease. Pain is the most common symptom in endometriosis. Endometriosis-associated pain is caused by inflammation, and is related to aberrant innervation. Alth...

Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis: A meta-analysis.

Mar 09, 2020

The association between Interleukin (IL)-17A and IL-17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies. This meta-analysis aimed to determine the association be...

Association of blood pressure with knee cartilage composition and structural knee abnormalities: data from the osteoarthritis initiative.

Mar 09, 2020

To investigate the associations of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with changes in knee cartilage composition and joint structure over 48 months, using magnetic reson...

Evaluating naloxegol for the treatment of opioid-induced constipation.

Mar 05, 2020

: Due to the increased use of opioids for pain and their abuse globally, the rate of restrictive side effects is elevating. Opioid-induced constipation (OIC) is probably the most widespread, underdiag...

To What Extent Does Clinically Assisted Nutrition and Hydration Have a Role in the Care of Dying People?

Mar 05, 2020

The question over whether to administer clinically assisted nutrition and hydration (CANH) to a dying patient is controversial, with much debate concerning this sensitive issue. The administration of ...

Opioid growth factor and its derivatives as potential non-toxic multifunctional anticancer and analgesic compounds.

Mar 05, 2020

Despite significant research progress on the pathogenesis, molecular biology, diagnosis, treatment, and prevention of cancer its morbidity and mortality is still high around the world. The emerging re...

Promoting Reproducible Research for Characterizing Nonmedical Use of Medications Through Data Annotation: Description of a Twitter Corpus and Guidelines.

Mar 05, 2020

Social media data are being increasingly used for population-level health research because it provides near real-time access to large volumes of consumer-generated data. Recently, a number of studies ...

Migraine With Aura as Early Disease Marker in Hereditary Dutch-Type Cerebral Amyloid Angiopathy.

Mar 05, 2020

Background and Purpose- To determine whether migraine, which has often been described as an inaugural manifestation in monogenic cerebrovascular syndromes, is associated with cerebral amyloid patholog...

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