Mar 02, 2020

Opioid agonist activation at the mu opioid receptor (MOR) can lead to a wide variety of physiological responses. Many opioid agonists share the ability to selectively and preferentially activate speci...

Mar 02, 2020

Morphine-3-glucuronide (M3G), the main metabolite of morphine, has been implicated in the development of tolerance and of opioid-induced hyperalgesia, both limiting the analgesic use of morphine. We e...

Mar 02, 2020

In the past decade, there has been a rising trend in the emergency department (ED) visits in the US and these visits carry a significant burden of prescription opioids. This study utilized the latest ...

Mar 02, 2020

Migraine is a debilitating condition that affects approximately 16% of adults and is the fifth leading cause of emergency department visits in the United States. There are several treatment options fo...

Mar 02, 2020

gammaCore is cleared by the FDA for acute and preventive treatment of cluster headache and the acute treatment of migraine in adults. Previously, only 2 treatments were approved for acute treatment of...

Mar 02, 2020

Chronic daily headache is a group of headache syndromes including most commonly chronic migraine and chronic tension-type headache, which often overlap, are complicated by medication overuse and are d...

Mar 02, 2020

Migraine is a chronic disorder with episodic attacks, and patients with a migraine often report that certain factors can trigger their headache, with chocolate being the most popular type of food-base...

Mar 02, 2020

An epidural nerve block injection is the most common modality of treatment for control of low backache associated with radiating pain. Epidural catheter injections are also widely used by pain physici...

Mar 02, 2020

Spinal epidural abscess is a rare pathology with an incidence that has tripled in the past two decades. Ventral cervical epidural abscesses (vCEA) of the cervical spine pose particular treatment chall...

Mar 02, 2020

Outcome improvement is a major goal of pancreatic surgery. Such efforts include decreasing perioperative narcotic use to optimize care and reduce potential contributions to the opioid crisis. Ketorola...

Mar 02, 2020

Multiple sclerosis (MS) is often associated with fatigue, with an increased prevalence of sleep disorders compared to the general population, notably restless legs syndrome (RLS). The aim of this stud...

Mar 02, 2020

The presence of a disease continuum in inflammatory arthritis (IA) is a recognised concept, with distinct stages from at-risk stage (presence of anti citrullinated-peptide autoantibody) to diagnosis o...

Mar 02, 2020

The aim of this study was to examine the concurrent and predictive relations between healthy toddlers' pain behavior and cardiac indicators (i.e., heart rate [HR], respiratory sinus arrhythmia [RSA]) ...

Mar 02, 2020

Our research group recently published a positive association between early postoperative pain and 30-day postoperative complications in a broad surgical population. To investigate whether heterogeneit...

Mar 02, 2020

Tissue acidosis due to ischemia occurs under several pathological conditions, and is thought to contribute to pain in these circumstances. TRPV1, TRPA1 and ASICs are known to be sensitive to acidic pH...

Mar 02, 2020

The dorsal root ganglia is a key structure in nociception and chronic pain disorders. Several gene expression studies of dorsal root ganglia in pre-clinical pain models have been performed, but it is ...

Mar 02, 2020

Chronic midline low back pain is the number one reason for disability in the United States despite the prolific use of medical and surgical interventions. Notwithstanding the widespread use of epidura...

Mar 02, 2020

Pregabalin is approved for the management of neuropathic pain, partial-onset seizures, and fibromyalgia. Although it is considered to have low potential for abuse, reports of misuse of pregabalin are ...

Mar 02, 2020

Individuals with hypermobility spectrum disorder or hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) are increasingly encountered by gastroenterologists and pose complex clinical challenges. Uncontrolled...

Mar 02, 2020

Fibromyalgia is a rheumatologic syndrome leading to increased pain sensitivity, sleep disturbance, fatigue, stiffness, and tenderness of joints, muscles, and tendons due to dysregulation of neurophysi...