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Pain General

Distinct tribological endotypes of pathological human synovial fluid reveal characteristic biomarkers and variation in efficacy of viscosupplementation at reducing local strains in articular cartilage.

Feb 28, 2020

Viscosupplementation has been used for decades to treat mild to moderate osteoarthritis, yet it is unknown if the lubricating function of different pathological synovial fluids (SF) vary, or if they r...

Cardiac glycoside digoxin ameliorates pro-inflammatory cytokines in PBMCs of rheumatoid arthritis patients in vitro.

Feb 28, 2020

Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by hyperplasia of the synovial membrane along with persistent inflammation of joints. Earlier studies suggest the crucial role...

The Comparison of the Biological Rhythms of Patients with Fibromyalgia Syndrome with Biological Rhythms of Healthy Controls.

Feb 28, 2020

BACKGROUND Fibromyalgia syndrome (FMS) is a rheumatic disease characterized by diffuse body pain and decreased muscle function. The aim of the present study was to compare the biological rhythms of pa...

Identification of MOR-Positive B Cell as Possible Innovative Biomarker (Mu Lympho-Marker) for Chronic Pain Diagnosis in Patients with Fibromyalgia and Osteoarthritis Diseases.

Feb 28, 2020

Fibromyalgia (FM) diagnosis follows the American College of Rheumatology (ACR) criteria, based on clinical evaluation and written questionnaires without any objective diagnostic tool. The lack of spec...

Force-time curve features of handgrip strength in fibromyalgia syndrome.

Feb 28, 2020

The aim of this study was to compare the handgrip strength (HGs), assessed with a cylindrical-shape grip device, of fibromyalgia syndrome (FM) patients with healthy subjects and to demonstrate the rel...

Comparison of sleep structure in patients with fibromyalgia and healthy controls.

Feb 28, 2020

Sleep disturbances such as nonrestorative sleep and nighttime awakenings play a crucial role in fibromyalgia (FMS). Pain and sleep disturbances show a bidirectional relationship which affect outcomes ...

Current and Emerging Pharmacotherapy for Fibromyalgia.

Feb 28, 2020

. Fibromyalgia syndrome (FMS) is a pain disorder with an estimated prevalence of 1-5%. It is associated with a variety of somatic and psychological disorders. Its exact pathogenesis is still unclear b...

The association between ambient temperature and clinical visits for inflammation-related diseases in rural areas in China.

Feb 28, 2020

The association between temperature and mortality has been widely reported. However, it remains largely unclear whether inflammation-related diseases, caused by excessive or inappropriate inflammatory...

Antinociceptive Effect of the Essential Oil of (female) Leaves on Adult Zebrafish ().

Feb 28, 2020

Raddi (Anacardiaceae) is popularly known in Brazil as and has pharmacological use as an astringent, antidiarrheal, anti-inflammatory, depurative, diuretic, and antifebrile agent. Although the neurop...

The Impact of Morphine Equivalent Daily Dose Threshold Guidelines on Prescribed Dose in a Workers' Compensation Population.

Feb 28, 2020

Prescription opioid overdose has increased markedly and is of great concern among injured workers receiving workers' compensation insurance. Given the association between high daily dose of prescripti...

Effects of transcutaneous electrical nerve stimulation on physical symptoms in advanced cancer patients receiving palliative care.

Feb 28, 2020

Transcutaneous electrical nerve stimulation (TENS) is primarily used for pain, but might be useful for various other physical symptoms, including nausea, fatigue, dyspnea, and constipation. However, f...

Chronic disease comorbidity in patients with oral leukoplakia: A matched case-control study.

Feb 28, 2020

The purpose of this study was to investigate the presence of chronic diseases in patients with oral leukoplakia (OL) compared to controls matched for age group, gender, smoking and alcohol use.This ca...

Using contributing causes of death improves prediction of opioid involvement in unclassified drug overdoses in US death records.

Feb 28, 2020

A substantial share of fatal drug overdoses is missing information on specific drug involvement, leading to under-reporting of opioid-related death rates and a misrepresentation of the extent of the o...

Opioid Use After ED Visits for Acute Pain

Feb 26, 2020

While the frequency of short-term side effects of opioids are well-known, the long-term risks of opioid use are inadequately quantified. For a study published in Annals of Emergency Medicine, my colle...

Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine.

Feb 25, 2020

Migraine is a very common, multifactorial, and recurrent central nervous system disorder that causes throbbing headache, photophobia, phonophobia, nausea, and disability. Migraine occurs more often in...

Treatment of Vestibular Migraine: A Systematic Review and Meta-analysis.

Feb 25, 2020

To assess the efficacy of the various therapies used for the prevention of vestibular migraine (VM).Primary studies were identified though PubMed, Scopus, PsycINFO, and Cochrane Library by two indepen...

Short and Mid-Term Predictors of Response to OnabotulinumtoxinA: Real-Life Experience Observational Study.

Feb 25, 2020

To identify clinical predictors of excellent response to OnabotulinumtoxinA in patients with chronic migraine (CM) at 6 and 12 months of follow-up.Clinical predictors of response to Onabotulinumtoxin...

The impact of external trigeminal nerve stimulator (e-TNS) on prevention and acute treatment of episodic and chronic migraine: A systematic review.

Feb 25, 2020

The aim of this systematic review was to analyze the effectiveness and safety of the external trigeminal nerve stimulator (eTNS) for the prevention and acute treatment of migraine attacks in episodic ...

Framingham Risk Stratification of Middle-Aged Migraineurs.

Feb 25, 2020

. Migraine is a common primary headache disorder involving about 10-15% of the whole population. Several epidemiological and prospective studies showed a link between migraine (especially migraine wit...

SMN gene copy number analysis by exome-seq: assisting SMA diagnosis and carrier screening.

Feb 25, 2020

Spinal muscular atrophy (SMA) is a leading genetic cause of infant death, influenced by the copy number of two highly-homologous genes: SMN1 and SMN2. Although exome-seq is widely applied for genetic ...

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