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Pain General

Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition from Acute to Chronic Low Back Pain.

Feb 25, 2020

A number of factors, including heritability and the environment, contribute to risk of transition from acute low back pain (ALBP) to chronic low back pain (CLBP). The aim of this study was to A) compa...

The Influence of a Positive Empathetic Interaction on Conditioned Pain Modulation and Manipulation Induced Analgesia in People with Lateral Epicondylalgia.

Feb 25, 2020

Conditioned pain modulation (CPM) and manipulation induced analgesia (MIA) are two forms of endogenous analgesia. Many forms of analgesia can be influenced by the nature of the patient clinician inter...

Effect on Opioids Requirement of Early Administration of Intranasal Ketamine for Acute Traumatic Pain.

Feb 25, 2020

To evaluate the efficacy and safety of early administration of low-dose intranasal ketamine on reducing the need for opioid and non-opioid analgesic agents in emergency department (ED) patients with a...

Pain-related Self-efficacy Among People with Back Pain: A Systematic Review of Assessment Tools.

Feb 25, 2020

Before an intervention can be implemented to improve pain-related self-efficacy, assessment is required. The aim of the present study was to provide a systematic review on which self-efficacy scales a...

Hypervigilance for Bodily Sensations in the Back During a Movement Task in People with Chronic and Recurrent Low Back Pain.

Feb 25, 2020

The current study assessed the role of hypervigilance for bodily sensations in the back in long term low back pain (LBP) problems.People with chronic low back pain (CLBP), recurrent low back pain (RLB...

How does the joint Dermatology-Rheumatology clinic benefit both patients and Dermatologists?

Feb 25, 2020

Psoriasis (Pso) and psoriatic arthritis (PsA) are chronic and debilitating diseases which often develop in the same patient and are linked to a wide range of comorbid conditions. Dermatologists and Rh...

Impact of fatigue on health-related quality of life and illness perception in a monocentric cohort of patients with systemic lupus erythematosus.

Feb 25, 2020

Fatigue is a very common and debilitating symptom in patients with systemic lupus erythematosus (SLE), even among those with a mild or inactive disease. The objective of this study is to define fatigu...

Effects of a functional training programme in patients with Fibromyalgia: A 9-years prospective longitudinal cohort study.

Feb 25, 2020

There are evidences that physical exercise is an effective instrument for improving physical fitness, health and quality of life and causes beneficial effects on the symptoms of patients with fibromya...

Bioinformatics analysis of gene and microRNA targets for fibromyalgia.

Feb 25, 2020

Fibromyalgia (FM) is the most common chronic pain disease in middle-aged women. Patients may also complain of migraine, irritable bowel syndrome and depression, which seriously affect their work and l...

Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients.

Feb 25, 2020

Advancements in nucleic acid sequencing technology combined with an unprecedented availability of metadata have revealed that 45% of the human genome constituted by transposable elements (TEs) is not ...

Association between lower back pain and lower extremity pain among young volleyball players: A cross-sectional study.

Feb 25, 2020

Lower back pain (LBP), as well as lower extremity injuries, are major problems among young volleyball players. Nevertheless, only few studies have focused on the relationship between lower extremity i...

Investigation of the Effect of Secreted Factors from Mesenchymal Stem Cells on Disc Cells from Degenerated Discs.

Feb 25, 2020

Low back pain is experienced by a large number of people in western countries and may be caused and influenced by many different pathologies and psychosocial factors including disc degeneration. Disc ...

Primary culture of mouse adipose and fibrous synovial fibroblasts under normoxic and hypoxic conditions.

Feb 25, 2020

Synovial fibroblasts have attracted considerable attention in studies of joint diseases. Although mice are useful and powerful in in vitro and in vivo experiments, primary cultures of mouse synovial f...

Depression and trait-anxiety mediate the influence of clinical pain on health-related quality of life in fibromyalgia.

Feb 25, 2020

Fibromyalgia syndrome (FMS) is a chronic pain condition associated with a substantial decrease in health-related quality of life (HRQoL). This study investigated the relationships of HRQoL with clinic...

A Multi-Centered Case Series Highlighting the Clinical Use and Dosing of Lidocaine and Mexiletine for Refractory Cancer Pain.

Feb 25, 2020

Lidocaine infusion for pain control has been used for years. While some centers transition from continuous infusion lidocaine to oral mexiletine, there are no published studies to guide this conversio...

Law, Culture, and Fear: A Qualitative Study of Health Professionals' Perceptions of Narcotic Use Related to Cancer Pain.

Feb 25, 2020

Studies have shown barriers to appropriate narcotic use in the Middle East have negatively impacted patient outcomes. This study aimed to explore health professionals' perspectives regarding opioid us...

Prenatal Substance Use Disorders and Dental Caries in Children.

Feb 25, 2020

Substance use is common in women of reproductive age, but limited data exist on the dental health of their children, including risk of caries. We conducted a longitudinal cohort study of 790,758 infan...

Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives.

Feb 25, 2020

Morphine and its derivatives play inevitably important role in the μ-opioid receptor (MOR) targeted antinociception. A structure-activity relationship study is presented for novel and known orvinol a...

microRNA-422a Inhibits DCC Expression in a Manner Dependent on SNP rs12607853.

Feb 25, 2020

DCC netrin 1 receptor (DCC) affects the structure and function of the dopamine circuitry, which in turn affects the susceptibility to developing addiction. In a previous study, we found that single nu...

nVNS for Vestibular Migraine

Feb 24, 2020

Although data indicate that vestibular migraine (VM) is the most common neurologic cause of vertigo in adults, no FDA-approved agents exist for its treatment. With few studies having pursued rescue tr...

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