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Pain General

Intravenous Endothelin-1 Infusion Does Not Induce Aura or Headache in Migraine Patients With Aura.

Jan 30, 2020

To investigate whether intravenously infused provokes migraine aura and migraine headache in migraine patients with aura.Migraine with aura has been associated with endothelial dysfunction and increas...

Impact of Melatonin on Skeletal Muscle and Exercise

Jan 30, 2020

Skeletal muscle disorders are dramatically increasing with human aging with enormous sanitary costs and impact on the quality of life. Preventive and therapeutic tools to limit onset and progression o...

Sleep and Pain in Subjects with Fibromyalgia and Comorbid Insomnia: Double-blind, Crossover, Study of Suvorexant 20 mg versus Placebo.

Jan 30, 2020

The chronic pain disorder, fibromyalgia, is associated with sleep disturbance, typically sleep maintenance. No studies have evaluated the effect of sleep medication on pain sensitivity in this populat...

Primary Pulmonary MALT Lymphoma: A Case Report and Literature Review.

Jan 30, 2020

Primary pulmonary MALT (mucosa-associated lymphoid tissue) lymphoma is a rare entity that imposes a rigorous and demanding diagnostic work-up.We present the case of a 74-year-old female non-smoker wit...

Use of Complementary and Integrative Therapies by Fibromyalgia Patients

Jan 30, 2020

To reevaluate the frequency and pattern of complementary and integrative medicine (CIM) use in patients with fibromyalgia (FM).Consecutive patients with FM who were referred to the Mayo Clinic fibromy...

Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production.

Jan 30, 2020

Abatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by ex...

Neural substrates for post-stroke complex regional pain syndrome type I: a retrospective case-control study using voxel-based lesion symptom mapping analysis.

Jan 30, 2020

Post-stroke Complex Regional Pain Syndrome (CRPS) is characterized by swelling, pain and changes in the skin that appear on the affected wrist and hand. In this retrospective study, we analyzed the re...

Outcomes of Prescription Opioid Dose Escalation for Chronic Pain

Jan 30, 2020

The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms asso...

Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis?

Jan 30, 2020

Non-invasive measures of neuroinflammatory processes in humans could substantially aid diagnosis and therapeutic development for many disorders, including chronic pain. Several proton Magnetic Resonan...

Shared liability to pain, common mental disorders, and long-term work disability differs among women and men.

Jan 27, 2020

Knowledge of factors involved in the associations between pain, common mental disorders and future work incapacity is still scarce. The aim of this study was to examine the overlap between genetic and...

c-Jun/p38MAPK/ASIC3 pathways specifically activated by NGF through TrkA is crucial for mechanical allodynia development.

Jan 27, 2020

Mechanical allodynia is a cardinal sign of several inflammatory pain disorders where Nerve Growth Factor, a prototypic neurotrophin, plays a crucial role by binding to TrkA receptors. Here, we took th...

Neck Pain and Headache Following Whiplash Injury

Jan 27, 2020

Neck pain and headache are two of the most common complications of whiplash injury. Therefore, we performed a systematic literature search on PubMed and Embase for publications reporting on the preval...

Pharmacological characterization of a rat Nav1.7 loss-of-function model with insensitivity to pain.

Jan 27, 2020

Sodium channel Nav1.7, encoded by the SCN9A gene, is a well validated target that plays a key role in controlling pain sensation. Loss-of-function mutations of Nav1.7 can cause a syndrome of profound ...

Brain networks and endogenous pain inhibition are modulated by age and sex in healthy rats.

Jan 27, 2020

Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women and older people, making...

Effect of Early Surgery vs Endoscopy-First Approach on Pain in Patients With Chronic Pancreatitis: The ESCAPE Randomized Clinical Trial.

Jan 24, 2020

For patients with painful chronic pancreatitis, surgical treatment is postponed until medical and endoscopic treatment have failed. Observational studies have suggested that earlier surgery could miti...

The Growth in Magic: Anti-Science Behavior Is on the Rise & Gaining Ground

Jan 22, 2020

There has been a rise in many forms of science-rejection, ranging from vaccine hesitancy and refusal, antithesis to research investment, and legislation that would encourage factual-relativism. Unless...

First U.S. Patient With Coronavirus ID'd in Washington State

Jan 21, 2020

TUESDAY, Jan. 21, 2020 (HealthDay News) -- The first U.S. case of a new coronavirus illness that originated in central China has been identified in a patient in Washington State, federal health of...

Marked sexual dimorphism in neuroendocrine mechanisms for the exacerbation of paclitaxel-induced painful peripheral neuropathy by stress.

Jan 17, 2020

Chemotherapy-induced neuropathic pain is a serious adverse effect of chemotherapeutic agents. Clinical evidence suggests that stress is a risk factor for development and/or worsening of chemotherapy-i...

Prescription of analgesics to long-term survivors of cancer in early adulthood, adolescence and childhood in Norway: a national cohort study.

Jan 17, 2020

Increasing numbers survive cancers in childhood and adolescence. Long-term survivors of cancers in adulthood have increased prevalence of pain and consumption of analgesics. It is not established whet...

An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery.

Jan 17, 2020

Alleviating chronic pain is challenging, due to lack of drugs that effectively inhibit nociceptors without off target effects on motor or central neurons. Dorsal root ganglia (DRG) contain nociceptive...

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