Jan 27, 2020

Sodium channel Nav1.7, encoded by the SCN9A gene, is a well validated target that plays a key role in controlling pain sensation. Loss-of-function mutations of Nav1.7 can cause a syndrome of profound ...

Jan 27, 2020

Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women and older people, making...

Jan 24, 2020

For patients with painful chronic pancreatitis, surgical treatment is postponed until medical and endoscopic treatment have failed. Observational studies have suggested that earlier surgery could miti...

Jan 22, 2020

There has been a rise in many forms of science-rejection, ranging from vaccine hesitancy and refusal, antithesis to research investment, and legislation that would encourage factual-relativism. Unless...

Jan 21, 2020

TUESDAY, Jan. 21, 2020 (HealthDay News) -- The first U.S. case of a new coronavirus illness that originated in central China has been identified in a patient in Washington State, federal health of...

Jan 17, 2020

Chemotherapy-induced neuropathic pain is a serious adverse effect of chemotherapeutic agents. Clinical evidence suggests that stress is a risk factor for development and/or worsening of chemotherapy-i...

Jan 17, 2020

Increasing numbers survive cancers in childhood and adolescence. Long-term survivors of cancers in adulthood have increased prevalence of pain and consumption of analgesics. It is not established whet...

Jan 17, 2020

Alleviating chronic pain is challenging, due to lack of drugs that effectively inhibit nociceptors without off target effects on motor or central neurons. Dorsal root ganglia (DRG) contain nociceptive...

Jan 17, 2020

Race disparities in pain care are well-documented. Given that the majority of Black patients are treated by White providers, patient-provider racial discordance is one hypothesized contributor to thes...

Jan 17, 2020

Patellofemoral pain (PFP) is a common complaint among young sports active adolescents. This study evaluated the longitudinal changes in pro-nociceptive and anti-nociceptive mechanisms in young adolesc...

Jan 08, 2020

Significantly more patients treated with Ubrelvy versus placebo achieved pain freedom two hours post-treatment TUESDAY, Dec. 24, 2019 (HealthDay News) -- Ubrelvy (ubrogepant) tablets have been ap...

Jan 07, 2020

Percentage of critical care admissions and suicidal intent increased in each era. MONDAY, Dec. 30, 2019 (HealthDay News) -- The severity of pediatric admissions for acute opioid ingestions, especia...

Dec 27, 2019

The longer patients continue with buprenorphine treatment, the lower their risk of adverse outcomes.   THURSDAY, Dec. 26, 2019 (HealthDay News) -- Buprenorphine treatment may be needed ...

Dec 18, 2019

At the age of 3 months, Charlotte Figi had her first seizure. She was later diagnosed with Davet Syndrome, a rare form of epilepsy. Her seizures continued, increasing in both frequency and severity. I...

Dec 05, 2019

THURSDAY, Dec. 5, 2019 (HealthDay News) -- Individuals with chronic pain who use daily cannabis have lower odds of using illicit opioids, according to a Canadian study published online Nov. 19 in PLOS...

Dec 04, 2019

WEDNESDAY, Dec. 4, 2019 (HealthDay News) -- Imaging is obtained for about one in three patients with emergency department visits for low back pain, according to a study published online Nov. 19 in the...

Nov 26, 2019

TUESDAY, Nov. 26, 2019 (HealthDay News) -- In an expert panel consensus, published online Nov. 12 in the Journal of the American Academy of Dermatology, opioid-prescribing guidelines are presented for...

Nov 19, 2019

TUESDAY, Nov. 19, 2019 (HealthDay News) -- Acute treatment of migraine with ubrogepant leads to significantly greater rates of pain freedom at two hours than placebo, according to a study published on...

Nov 08, 2019

Opioid-related hospitalizations among patients with cancer appear to be rare but are increasing slowly over time. Clinicians should screen for risk factors of opioid abuse prior to prescribing opioids...

Nov 05, 2019

TUESDAY, Nov. 5, 2019 (HealthDay News) -- From 2010 to 2016, there was an increase in the number of adolescents admitted to emergency departments for confirmed sexual abuse, according to a research le...