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Pain General

MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling.

Mar 11, 2024

Secreted microRNAs (miRNAs) have been detected in various body fluids including the cerebrospinal fluid, yet their direct role in regulating synaptic transmission remains uncertain. We found that intr...

The Effect of Unpredictability on Perception of Pain

Mar 02, 2024

Despite being widely assumed, the worsening impact of unpredictability on pain perception remains unclear because of conflicting empirical evidence, and a lack of systematic integration of past resear...

Efficacy and Safety of Botulinum Toxin Type A in the Treatment of Trigeminal Neuralgia: An update systematic review with meta-analyses.

Feb 26, 2024

This review aims to analyze the current data for the use of botulinum toxin type A (BTX-A) in the treatment of trigeminal neuralgia (TN) and highlight the evidence for its efficacy and safety. Pain ma...

RNA helicase IGHMBP2 regulates THO complex to ensure cellular mRNA homeostasis.

Feb 19, 2024

RNA helicases constitute a large protein family implicated in cellular RNA homeostasis and disease development. Here, we show that the RNA helicase IGHMBP2, linked to the neuromuscular disorder spinal...

SOMATOSENSORY PROFILING OF PATIENTS WITH CLUSTER HEADACHE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Feb 19, 2024

The objectives were 1) to synthesize Quantitative Sensory Testing results in Cluster Headache (CH) patients and to identify somatosensory differences from healthy subjects (HS) and 2) between symptoma...

Overcoming patient pain together: Breast cancer patients and caregivers' pre-treatment psychosocial distress linked to patients' pain interference during the first year of treatment.

Feb 12, 2024

Breast cancer patients experience treatment-related pain from surgery, radiation, chemotherapy, and long-term hormonal treatment, which can lead to poorer outcomes. Patient and family caregivers' psyc...

Women's Self-Management of Dyspareunia Associated with Endometriosis: A Qualitative Study.

Feb 12, 2024

Given the limitations of medical treatment for endometriosis, self-management is a critical component of symptom management, and providing patients with information and education is a necessary comple...

Pain Predictors in Patients in the Postanesthesia Care Unit.

Feb 05, 2024

To analyze the effects of pain-predicting factors on patients in the postanesthesia care unit (PACU).This is an observational and prospective study.This study was conducted at a University Hospital in...

The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study.

Feb 05, 2024

Previous epidemiological evidence suggests rheumatoid arthritis is associated with sarcopenia-related features. However, most of the current evidence is from cross-sectional studies, and the causal li...

Roadmap to the 'Chronic Pain GPS for Adolescents' Intervention: Content and Design Considerations for a Group Peer Support Intervention.

Feb 05, 2024

A biopsychosocial approach to understand and treat pain is crucial; however, there are limited socially-targeted interventions for adolescents with chronic pain. Peer support interventions implemented...

Unravelling the Left-Right Judgment Task in Chronic Low Back Pain: Insights through Behavioural, Electrophysiological, Motor Imagery, and Bodily Disruption Perspectives.

Feb 05, 2024

Bodily disruptions have been consistently demonstrated in individuals with chronic low back pain. The performance on the left-right judgment task has been purposed as an indirect measure of the cortic...

An improved conflict avoidance assay reveals modality-specific differences in pain hypersensitivity across sexes.

Jan 29, 2024

Abnormal encoding of somatosensory modalities (ie, mechanical, cold, and heat) are a critical part of pathological pain states. Detailed phenotyping of patients' responses to these modalities have rai...

Meaningful clinical outcomes for young people and parents when treated for chronic musculoskeletal pain in the UK: Q set development.

Jan 29, 2024

Previous studies have established a core outcome set for paediatric chronic pain clinical trials. The aim of this research was to establish which outcomes young people and parents considered important...

Genomic heterozygosity is associated with a lower risk of osteoarthritis.

Jan 22, 2024

Genomic heterozygosity has been shown to confer a health advantage in humans and play a protective role in complex diseases. Given osteoarthritis (OA) is a highly polygenic disease, we set out to dete...

Skeletal muscle index together with body mass index is associated with secondary osteoporosis in patients with rheumatoid arthritis.

Jan 22, 2024

The objective of this study was to explore the associations of body mass index (BMI), fat mass index (FMI), skeletal mass index (SMI) and secondary osteoporosis (OP) in patients with rheumatoid arthri...

Effects of Savoring Meditation on Positive Emotions and Pain-Related Brain Function: A Mechanistic Randomized Controlled Trial in People With Rheumatoid Arthritis.

Jan 22, 2024

Positive emotions are a promising target for intervention in chronic pain, but mixed findings across trials to date suggest that existing interventions may not be optimized to efficiently engage the t...

Comparison of intravenous ibuprofen and paracetamol for peri-operative analgesia in paediatric day care tonsillectomy.

Jan 15, 2024

To determine the effectiveness of intravenous ibuprofen and acetaminophen as perioperative analgesics in paediatric patients undergoing day- care tonsillectomy with general anaesthesia.The quasi-exper...

Health-related quality of life and clinical outcomes for magnetically controlled growing rod patients after treatment termination.

Jan 15, 2024

To determine the health-related quality of life (HRQoL) and clinical outcomes of children with early onset scoliosis (EOS) treated with magnetically controlled growing rods (MCGR) followed to definiti...

Editorial Commentary: Artificial Intelligence Analysis of Biomedical, Large, Clinical Registry Data Using Machine Learning Requires Tens of Thousands of Subjects and a Focus on Substantial Clinical Benefit: MCID Is too Low a Bar.

Jan 15, 2024

As the field of arthroscopic hip preservation surgery grows, large high-quality registries represent a foundational study design for establishing whether hip arthroscopy is effective for patients with...

Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice.

Jan 15, 2024

Chronic pain presents an enormous personal and economic burden and there is an urgent need for effective treatments. In a mouse model of chronic neuropathic pain, selective silencing of key neurons in...

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