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Pain General

The Pain Course: a randomised controlled trial and economic evaluation of an internet-delivered pain management program.

Oct 11, 2021

There is interest in the potential of internet-delivered programs to cost-effectively increase access to pain management for people with chronic pain. However, few large-scale clinical and economic ev...

Does the Addition of iPACK Block to Adductor Canal Block Provide Improved Analgesic Effect in Total Knee Arthroplasty? A Systematic Review and Meta-Analysis.

Oct 04, 2021

The interspace between popliteal artery and the capsule of posterior knee (iPACK) block was proposed in recent years to relieve posterior knee pain. Since adductor canal block (ACB) and iPACK involve ...

The effects of a new seat suspension system on whole body vibration exposure and driver low back pain and disability: Results from a randomized controlled trial in truck drivers.

Sep 27, 2021

Through a randomized controlled trial, we evaluated the effects of an electro-magnetic active seat suspension that reduces exposure of a long-haul truck driver to whole body vibration (WBV) on low bac...

Emerging evidence of Toll-like receptors as a putative pathway linking maternal inflammation and neurodevelopmental disorders in human offspring: a systematic review.

Sep 27, 2021

Inflammation is increasingly recognised to play a major role in gene-environment interactions in neurodevelopmental disorders (NDDs). The effects of aberrant immune responses to environmental stimuli ...

Sleep problems in pain patients entering tertiary pain care: the role of pain-related anxiety, medication use, self-reported diseases, and sleep disorders.

Sep 27, 2021

Chronic pain and sleep problems frequently co-occur. Pain itself disturbs sleep, but other factors may also contribute to sleep problems in pain patients. This cross-sectional study of 473 patients (6...

A systematic review of addiction substitution in recovery: Clinical lore or empirically-based?

Sep 20, 2021

This systematic review synthesized the literature examining addiction substitution during recovery from substance use or behavioral addictions. A total of 96 studies were included with sample sizes ra...

Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via the NLRP3 inflammasome axis in nerve-injured rats.

Sep 20, 2021

Neuropathic pain has been shown to be modulated by the activation of the chemokine C-X-C motif ligand 12 (CXCL12)/chemokine CXC receptor 4 (CXCR4) dependent nucleotide-binding oligomerization domain (...

Pain phenotypes among adults living with cerebral palsy and spina bifida.

Sep 20, 2021

Chronic pain is the most commonly reported physical symptomology of cerebral palsy (CP) and spina bifida (SB) throughout the lifespan, and yet, pain is perhaps the least understood comorbidity in thes...

Outpatient Pain Management Via Telementoring Proves Effective

Sep 15, 2021

Although opioid prescribing and opioid overdose are very important topics in pain management medicine, there are not enough pain management specialists to handle all the patients in need. For a paper ...

Adjunct interventions to standard medical management of buprenorphine in outpatient settings: A systematic review of the evidence.

Sep 13, 2021

A growing body of research has examined adjunctive interventions supportive of engagement and retention in treatment among patients receiving buprenorphine for opioid use disorder (OUD). We conducted ...

Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study.

Sep 13, 2021

Medication-overuse headache (MOH) is a relatively frequently occurring secondary headache caused by overuse of analgesics and/or acute migraine medications. It is believed that MOH is associated with ...

Migraine patients in Germany - need for medical recognition and new preventive treatments: results from the PANORAMA survey.

Sep 13, 2021

Migraine is a primary headache disorder characterized by recurrent attacks that may have a significant impact on patients' daily life. Treatment options must often be re-evaluated in light of efficacy...

Impact of COVID-19 pandemic on migraine management in the United States: insights from migraine tracking app users.

Sep 13, 2021

The nature of COVID-19 pandemic measures has altered the clinical management of migraine, and has also created barriers to evaluate the impact of such measures of migraine patients. Using the Migraine...

Effects of Physiotherapy vs. Acupuncture in Quality of Life, Pain, Stiffness, Difficulty to Work and Depression of Women with Fibromyalgia: A Randomized Controlled Trial.

Sep 13, 2021

Fibromyalgia is a chronic clinical condition characterized by pain and other associated symptoms that have a negative impact on the quality of life of the affected person. The objective of this study ...

Effects of Non-Pharmacological Treatment on Pain, Flexibility, Balance and Quality of Life in Women with Fibromyalgia: A Randomised Clinical Trial.

Sep 13, 2021

The functional deficits in people with fibromyalgia can be related to the level of physical activity performed. This study investigated the effectiveness of an active exercise programme versus exercis...

Effectiveness of myofascial release on pain, sleep, and quality of life in patients with fibromyalgia syndrome: A systematic review.

Sep 13, 2021

There is limited evidence on the effects of myofascial release on fibromyalgia symptoms. This review aims to update the evidence on the effectiveness of myofascial release on pain, sleep, and quality ...

The impact of community-level prevention strategies on high-dose opioid dispensing rates: 2014-2019.

Sep 13, 2021

Prescription opioids played a major role in the current opioid overdose epidemic. High rates of opioid prescribing and dispensing exposed many people to opioids, and high-dose opioid prescriptions (e....

Pharmacological and metabolic characterization of the novel synthetic opioid brorphine and its detection in routine casework.

Sep 13, 2021

After their first emergence in 2009, Novel synthetic opioids (NSO) have become an emerging class of New Psychoactive Substances (NPS) on the market for these new drugs. So far, 67 NSO have been report...

Effects of lumbar spinal disorders on the vertical ground reaction force and Spatio-temporal parameters in gait.

Sep 13, 2021

Ground reaction forces are biomechanical data, providing information to investigate pathological gait. The vertical component of ground reaction force introduces the upward thrust force within gait pr...

Spinal cord injury in mice impacts central and peripheral pathology in a severity-dependent manner.

Sep 13, 2021

Chronic pain is a common medical complication experienced by those living with spinal cord injury (SCI) and leads to worsened quality of life. The pathophysiology of SCI pain is poorly understood, ham...

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