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Pain General

Adjunct interventions to standard medical management of buprenorphine in outpatient settings: A systematic review of the evidence.

Sep 13, 2021

A growing body of research has examined adjunctive interventions supportive of engagement and retention in treatment among patients receiving buprenorphine for opioid use disorder (OUD). We conducted ...

Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study.

Sep 13, 2021

Medication-overuse headache (MOH) is a relatively frequently occurring secondary headache caused by overuse of analgesics and/or acute migraine medications. It is believed that MOH is associated with ...

Migraine patients in Germany - need for medical recognition and new preventive treatments: results from the PANORAMA survey.

Sep 13, 2021

Migraine is a primary headache disorder characterized by recurrent attacks that may have a significant impact on patients' daily life. Treatment options must often be re-evaluated in light of efficacy...

Impact of COVID-19 pandemic on migraine management in the United States: insights from migraine tracking app users.

Sep 13, 2021

The nature of COVID-19 pandemic measures has altered the clinical management of migraine, and has also created barriers to evaluate the impact of such measures of migraine patients. Using the Migraine...

Effects of Physiotherapy vs. Acupuncture in Quality of Life, Pain, Stiffness, Difficulty to Work and Depression of Women with Fibromyalgia: A Randomized Controlled Trial.

Sep 13, 2021

Fibromyalgia is a chronic clinical condition characterized by pain and other associated symptoms that have a negative impact on the quality of life of the affected person. The objective of this study ...

Effects of Non-Pharmacological Treatment on Pain, Flexibility, Balance and Quality of Life in Women with Fibromyalgia: A Randomised Clinical Trial.

Sep 13, 2021

The functional deficits in people with fibromyalgia can be related to the level of physical activity performed. This study investigated the effectiveness of an active exercise programme versus exercis...

Effectiveness of myofascial release on pain, sleep, and quality of life in patients with fibromyalgia syndrome: A systematic review.

Sep 13, 2021

There is limited evidence on the effects of myofascial release on fibromyalgia symptoms. This review aims to update the evidence on the effectiveness of myofascial release on pain, sleep, and quality ...

The impact of community-level prevention strategies on high-dose opioid dispensing rates: 2014-2019.

Sep 13, 2021

Prescription opioids played a major role in the current opioid overdose epidemic. High rates of opioid prescribing and dispensing exposed many people to opioids, and high-dose opioid prescriptions (e....

Pharmacological and metabolic characterization of the novel synthetic opioid brorphine and its detection in routine casework.

Sep 13, 2021

After their first emergence in 2009, Novel synthetic opioids (NSO) have become an emerging class of New Psychoactive Substances (NPS) on the market for these new drugs. So far, 67 NSO have been report...

Effects of lumbar spinal disorders on the vertical ground reaction force and Spatio-temporal parameters in gait.

Sep 13, 2021

Ground reaction forces are biomechanical data, providing information to investigate pathological gait. The vertical component of ground reaction force introduces the upward thrust force within gait pr...

Spinal cord injury in mice impacts central and peripheral pathology in a severity-dependent manner.

Sep 13, 2021

Chronic pain is a common medical complication experienced by those living with spinal cord injury (SCI) and leads to worsened quality of life. The pathophysiology of SCI pain is poorly understood, ham...

Muscle function, quality, and relative mass are associated with knee pain trajectory over 10.7 years.

Sep 13, 2021

Periarticular muscle plays an important role in the pathogenesis of musculoskeletal pain. We recently reported that pain population consists of distinct subgroups of which the causes and mechanisms ma...

Pragmatic trials of pain therapies: a systematic review of methods.

Sep 13, 2021

Pragmatic randomised clinical trials aim to directly inform clinical or health policy decision making. Here, we systematically review methods and design of pragmatic trials of pain therapies to examin...

Netrin1 and reelin signaling are required for the migration of anterolateral system neurons in the embryonic spinal cord.

Sep 06, 2021

Projection neurons of the spinal cord dorsal horn which transmit pain, itch and temperature information to the brain comprise the anterolateral system (AS). A recent molecular and genetic study showed...

Outcomes in patients with acute myocardial infarction and history of illicit drug use: a French nationwide analysis.

Aug 30, 2021

Several reports suggest that illicit drug use may be a major cause of acute myocardial infarction (AMI) independently of smoking habits and associated with a poorer prognosis. The aim of our study was...

Lost diagnoses in not otherwise specified headache in Emergency Department.

Aug 30, 2021

 The diagnosis of Not Otherwise Specified (NOS) headaches in the Emergency Department (ED) is frequent despite many specialist visits performed. The aim of the study was to examine specialist visits ...

Current Perspective on Retinal Migraine.

Aug 30, 2021

Retinal migraine was first formally described in 1882. Various terms such as "ocular migraine" and "ophthalmic migraine" have since been used interchangeably in the literature. The lack of a consisten...

Periorbital Nociception in a Progressive Multiple Sclerosis Mouse Model Is Dependent on TRPA1 Channel Activation.

Aug 30, 2021

Headaches are frequently described in progressive multiple sclerosis (PMS) patients, but their mechanism remains unknown. Transient receptor potential ankyrin 1 (TRPA1) was involved in neuropathic noc...

The Role of Pain Catastrophizing and Pain Acceptance in Performance-Based and Self-Reported Physical Functioning in Individuals with Fibromyalgia and Obesity.

Aug 30, 2021

Impaired physical functioning is one of the most critical consequences associated with fibromyalgia, especially when there is comorbid obesity. Psychological factors are known to contribute to perceiv...

Immunometabolic Modulatory Role of Naltrexone in BV-2 Microglia Cells.

Aug 30, 2021

: Naltrexone is an opioid receptor antagonist commonly used to treat opioid and alcohol dependence. The use of low dose naltrexone (LDN) was found to have anti-inflammatory properties for treatment of...

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