Aug 19, 2021

Erenumab is a monoclonal antibody, targeted against the calcitonin gene-related peptide (CGRP) receptor. Clinical studies have demonstrated prophylactic efficacy in both episodic (EM) and chronic migr...

Aug 19, 2021

Atogepant is an oral, small-molecule, calcitonin gene-related peptide receptor antagonist that is being investigated for the preventive treatment of migraine.In a phase 3, double-blind trial, we rando...

Aug 19, 2021

Juvenile-onset Fibromyalgia (JFM) is a chronic pain condition characterized by widespread musculoskeletal pain, fatigue, sleep difficulties, mood concerns, and other associated symptoms. Although diag...

Aug 19, 2021

The cause for the increased sensitivity of fibromyalgia (FM) patients to painful stimuli is unclear but sensitization of dorsal horn spinal cord neurons has been suggested. There, critical changes of ...

Aug 19, 2021

This study explored hypoglycaemia and metabolic crises, including hyperketosis, in patients with spinal muscular atrophy (SMA).The study comprised four adolescents aged 15-17 and six adults aged 19-37...

Aug 19, 2021

Prospective, randomized, placebo-controlled, double-blind exploratory study.To compare effects of dexmedetomidine or a subanesthetic dose of ketamine on the amplitude and latency of transcranial elect...

Aug 19, 2021

To investigate passive smoking throughout the life course and the risk of rheumatoid arthritis (RA), while accounting for personal smoking.We analyzed the Nurses' Health Study II prospective cohort, u...

Aug 19, 2021

Eurya nitida Korth. belonging to the family Theaceae is an evergreen shrub or small tree and is usually used as a very important ornamental tree and nectar source plant (Khan et al. 1992; Ma et al. 20...

Aug 19, 2021

In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been pee...

Aug 19, 2021

Patients with migraine suffer from high morbidity related to the repeated headache attacks, characteristic of the disorder, poor sleep, and a high prevalence of comorbid psychosocial disorders. Curren...

Aug 19, 2021

Large placebo responses often negatively affect randomized controlled trials within the pain area. Understanding different possible factors that influence the placebo response is therefore important. ...

Aug 19, 2021

Chronic neuropathic pain (NP) is a common and often debilitating secondary condition for persons with spinal cord injury (SCI) and is minimally responsive to existing pharmacological and nonpharmacolo...

Aug 17, 2021

“Tinnitus is a condition that affects approximately 10% of the adult population in the United States and can diminish one’s quality of life,” explains Hamid R. Djalilian, MD. “To date, there a...

Aug 16, 2021

Individuals who initiate injection drug use often receive assistance from an injection-knowledgeable peer. Persons who assist peers in injection initiation events often inject frequently, which height...

Aug 16, 2021

In this study, a rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the targeted analysis of 98 New Psychoactive Substances (NPS) from the hair...

Aug 16, 2021

One of the common disorders in people with quadriplegia is having a weak grip strength that can affect activities of daily living (ADL). This study presents the design of a soft robotic glove via pneu...

Aug 16, 2021

Altered brain structure and function is evident in adults with multisite chronic pain. Although many such adults trace their pain back to childhood, it has been difficult to disentangle whether centra...

Aug 16, 2021

Concomitant use of pregabalin with opioids and/or benzodiazepines is common, despite the increased risks. However, clinical trials suggest pregabalin can have an opioid-sparing effect when treating ac...

Aug 16, 2021

The Dysfunctional Chronic Pain (Dysfunctional CP) phenotype is an empirically-identifiable CP subtype with unclear pathophysiological mechanisms that cuts across specific medical CP diagnoses. This st...

Aug 12, 2021

“For most patients, pain control remains unsatisfactory,” explains Feng Pan, PhD, MMed, MBBS. “The few pharmacologic analgesic options available have limited efficacy and carry a substantial ris...