Apr 26, 2021

Chronic pain in childhood is an international public health problem. We conducted a systematic review and meta-analysis to provide a summary of the published evidence of pharmacological, physical, and...

Apr 22, 2021

Wastewater testing offers a cost-effective strategy for measuring population disease prevalence and health behaviors. For COVID-19, wastewater surveillance addresses testing gaps and provides an early...

Apr 22, 2021

The purpose of the current study was to: (1) determine the percentage of new orthopaedic patients reporting their symptoms to be acceptable at presentation, as measured by the Patient Acceptable Sympt...

Apr 22, 2021

to compare the outcomes of single position (SP) circumferential lumbar interbody fusion in lateral decubitus versus dual position (DP) fusion.A systematic literature review was performed in accordance...

Apr 22, 2021

Pain increases with age, disproportionately affects women, and is a major contributor to decreased quality of life. Because pain is dynamic, trajectories are important to consider. Few studies have ex...

Apr 22, 2021

Spinal cord stimulation (SCS) has been suggested as a treatment option for patients with painful diabetic neuropathy (PDN). We conducted a systematic review and undertook a meta-analysis on individual...

Apr 22, 2021

Although effective agents are available to prevent painful vaso-occlusive episodes of sickle cell disease (SCD), there are no disease-modifying therapies for ongoing painful vaso-occlusive episodes; t...

Apr 15, 2021

The fetoscopic approach to the prenatal closure of a neural tube defect (NTD) may offer similar advantages to the newborn compared to prenatal open closure of a NTD, with a reduction in maternal risks...

Apr 15, 2021

Acetyl fentanyl (AF) is a Schedule I fentanyl analog that has been increasingly seen in heroin and fentanyl polydrug toxicity overdoses in Michigan (MI). Drug users are often unaware of the presence o...

Apr 15, 2021

Total knee arthroplasty (TKA) is associated with significant postoperative pain. The population receiving TKA is generally elderly and often have multiple comorbidities that can present a challenge to...

Apr 15, 2021

We recently showed headache to be common in children (aged 7-11 years) and adolescents (aged 12-17) in Lithuania. Here we provide evidence from the same study of the headache-attributable burden.Fol...

Apr 15, 2021

Clinical studies have suggested that internal and/or external aversive cues may produce a negative affective-motivational component whereby maladaptive responses (plasticity) of dural afferent neurons...

Apr 15, 2021

The aim of this study was to review current evidence concerning potential risks and interactions associated with concomitant use of drugs indicated for the abortive treatment of migraine, namely tript...

Apr 15, 2021

The aim of this study was to analyse the 2020 burden of Systemic Lupus Erythematosus (SLE) in Europe, from the patients' perspective.In May 2020, Lupus Europe, the European umbrella patient associatio...

Apr 15, 2021

Exercise therapies are advocated in osteoarthritis (OA) clinical guidelines. However, challenges to accessing exercise may be limiting widespread uptake.To evaluate the effects of a self-directed web-...

Apr 12, 2021

To estimate the cost-effectiveness of tofacitinib for patients with moderate-to-severe rheumatoid arthritis (RA) who failed conventional synthetic disease-modifying antirheumatic drugs from the Chines...

Apr 09, 2021

Disclaimer: The thoughts and ideas in this post are Dr. Tuchler's alone and do not represent Kaiser Permanente’s positions, strategies, or opinions.   A tsunami is building. Even a...

Apr 08, 2021

The purpose of this paper is to discuss the history of cannabis, its benefits, risks and the federal re-legalization of cannabis for medical use in the USA.Thirty-six states have legalized cannabis as...

Apr 08, 2021

Motor neuron diseases are untreatable with common pharmacological approaches. Spinal Muscular Atrophy (SMA) is caused by SMN1 gene mutations leading to lowered SMN expression. Symptoms are alleviated ...

Apr 08, 2021

In a healthcare landscape in which costs increasingly matter, the authors sought to distinguish among the clinical and nonclinical drivers of patient length of stay (LOS) in the hospital following ele...