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Pain General

Decompression sickness after a highly conservative dive in a diver with known persistent foramen ovale: Case report.

Mar 25, 2021

A diver returned to diving, 15 months after an episode of neuro-spinal decompression sickness (DCS) with relapse, after which she had been found to have a moderate to large provoked shunt across a per...

Paradoxical Psoriasis in Children Receiving Anti-TNFα Treatment for Inflammatory/autoimmune Disease.

Mar 25, 2021

Tumor necrosis factor alpha inhibitors (TNFi) are widely used in children with autoimmune and autoinflammatory conditions. Although TNFi are approved to treat psoriasis, they have also been shown to p...

Patient Perceptions of Psoriatic Arthritis Management and Communication with Physicians in Australia: Results from a Patient Survey.

Mar 25, 2021

The objective of this report was to evaluate perceptions of psoriatic arthritis (PsA) treatment and satisfaction with healthcare professional (HCP) communication among patients with PsA in Australia, ...

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.

Mar 25, 2021

Arthritis typically involves recurrence and progressive worsening at specific predilection sites, but the checkpoints between remission and persistence remain unknown. Here, we defined the molecular a...

The Value of Total Knee Replacement in Patients With Knee Osteoarthritis and a Body Mass Index of 40 kg/m or Greater : A Cost-Effectiveness Analysis.

Mar 25, 2021

Total knee replacement (TKR) is an effective and cost-effective strategy for treating end-stage knee osteoarthritis. Greater risk for complications among TKR recipients with a body mass index (BMI) of...

Assessing Prescription Opioid Medical Use & Misuse in Parents & Offspring

Mar 22, 2021

According to recent data, nearly 50% of adolescents who misuse prescription opioids report obtaining the drugs from relatives or friends. Understanding the parental origins of adolescent prescription ...

The Efficacy of Rituximab in Patients with Neuromyelitis Optica Spectrum Disorder: a Real-World Study from Turkey.

Mar 22, 2021

Neuromyelitis optica spectrum disorders (NMOSD) are a group of antibody-mediated chronic inflammatory diseases of the central nervous system. Rituximab is a monoclonal antibody that leads to a reducti...

Impact of rheumatoid arthritis and biologic and targeted synthetic disease modifying antirheumatic agents on cancer risk and recurrence.

Mar 22, 2021

Several new therapeutic drugs are now available for the management of rheumatoid arthritis (RA). Given that RA has been associated with an increased risk of certain cancers like lymphoma and lung canc...

Perioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients.

Mar 18, 2021

Despite application of multimodal pain management strategies, patients undergoing spinal fusion surgery frequently report severe postoperative pain. Methadone and ketamine, which are N-methyl-d-aspart...

Enhanced Recovery After Surgery Protocol with Ultrasound-Guided Regional Blocks in Outpatient Plastic Surgery Patients Leads to Decreased Opioid Prescriptions and Consumption.

Mar 18, 2021

Opioids are a mainstay of pain management. To limit the use of opioids, enhanced recovery after surgery (ERAS) protocols implement multimodal approaches to treat postoperative pain.This paper aims to ...

Personalizing Cancer Pain Therapy: Insights from the Rational Use of Analgesics (RUA) Group.

Mar 18, 2021

A previous Delphi survey from the Rational Use of Analgesics (RUA) project involving Italian palliative care specialists revealed some discrepancies between current guidelines and clinical practice wi...

Pain Severity and Psychosocial Quality of Life in Adolescents with Migraine and Tension-Type Headache: Mediation by Perceived Expressed Emotion and Self-Esteem.

Mar 18, 2021

To investigate perceived expressed emotion (EE) and self-esteem in adolescents with primary headaches and to assess the psychologic factors, especially perceived EE, that may play a mediating role in ...

Partial and non responders to onabotulinumtoxinA can benefit from anti-CGRP monoclonal preventive treatment: a real-world evidence study.

Mar 18, 2021

Monoclonal antibodies targeting CGRP or its receptor (anti-CGRP mAbs) are proven to be effective treatments in migraine prevention. Real-world evidence studies assessing their efficacy are scarce.Our ...

Electroencephalographic Evaluation in Fibromyalgia: A Systematic Review.

Mar 18, 2021

. The evaluation of individuals with fibromyalgia is challenging. Electroencephalography is a promising resource for identifying physiological biomarkers in fibromyalgia, contributing to its diagnosis...

High cost of illness in fibromyalgia patients in Iran, irrespective of disease severity: A prospective cost study.

Mar 18, 2021

This study aimed to estimate the economic burden of fibromyalgia (FM) in 6 months, using a cost-diary, and to evaluate its relationship with the disease severity.This is a prospective cost-of-illness...

Dense Circuit Reconstruction to Understand Neuronal Computation: Focus on Zebrafish.

Mar 18, 2021

The dense reconstruction of neuronal wiring diagrams from volumetric electron microscopy data has the potential to generate fundamentally new insights into mechanisms of information processing and sto...

Managing noncommunicable diseases during the COVID-19 pandemic in Brazil: findings from the PAMPA cohort.

Mar 18, 2021

The objective was to identify the impact of social distance in the management of noncommunicable diseases (NCD) in the adult population from the state of Rio Grande do Sul, southern Brazil. This is an...

Predictors of functional capacity as measured by the Glittre activities of daily living test in women with rheumatoid arthritis.

Mar 18, 2021

Although pulmonary involvement is the most common extra-articular manifestation of rheumatoid arthritis (RA), traditional pulmonary function tests (PFTs) do not show a good correlation with the field ...

Patient perspectives on how to improve education on medication side effects: cross-sectional observational study at a rheumatology clinic in The Netherlands.

Mar 18, 2021

Rheumatoid arthritis (RA) patients often report lacking information on medication side effects. The aims of this study were to observe how rheumatology healthcare providers deliver medication informat...

Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies.

Mar 18, 2021

This narrative review represents an output from the International Association for the Study of Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based medicines (CBM) for pai...

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