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Pain General

Does aerobic exercise training alter responses to opioid analgesics in individuals with chronic low back pain?: a randomized controlled trial.

Jan 07, 2021

We tested whether aerobic exercise training altered morphine analgesic responses or reduced morphine dosages necessary for adequate analgesia. Chronic back pain patients were randomized to an 18-sessi...

Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice.

Jan 07, 2021

Patients with a history of early life stress (ELS) exposure have an increased risk of developing chronic pain and mood disorders later in life. The severity of ELS in patients with urologic chronic pe...

How should we treat palindromic rheumatism? A systematic literature review.

Jan 07, 2021

To perform a systematic literature review (SLR) analysing all studies that reported on the efficacy and safety of pharmacological treatments for palindromic rheumatism (PR).We performed a SLR using Pu...

Risk of solid cancers overall and by subtypes in patients with psoriatic arthritis treated with TNF inhibitors - a Nordic cohort study.

Jan 07, 2021

To investigate whether TNF inhibitors (TNFi) are associated with increased risk of solid cancer in patients with psoriatic arthritis (PsA).From the Nordic clinical rheumatology registers (CRR) here: S...

The JANUS of chronic inflammatory and autoimmune diseases onset during COVID-19 - A systematic review of the literature.

Jan 07, 2021

The diverse clinical manifestations of COVID-19 is emerging as a hallmark of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. While the initial target of SARS-CoV-2 is the r...

Assessing Prescription Analgesic Use in Older Adults With CKD

Jan 05, 2021

Opioids and NSAIDs are the most commonly used analgesics for managing pain in patients with chronic kidney disease (CKD), but these therapies come with important risks. “NSAIDs have direct nephrotox...

Efficacy and Safety Profile of Rectus Sheath Block in Adult Laparoscopic Surgery: A Meta-analysis.

Jan 04, 2021

Rectus sheath block (RSB) has been increasingly used for pain management after laparoscopic procedures but with a conflicting data on its analgesic efficacy. We conducted a systematic review and meta-...

Management of migraine in the emergency department: Findings from the 2010-2017 National Hospital Ambulatory Medical Care Surveys.

Jan 04, 2021

The study objective was to describe trends in the medical management of migraine in the emergency department (ED) using the 2010-2017 National Hospital Ambulatory Medical Care Survey (NHAMCS) datasets...

Vestibular migraine of childhood and recurrent vertigo of childhood: Diagnostic criteria consensus document of the committee for the classification of vestibular disorders of the bárány society and the international headache society.

Jan 04, 2021

This paper describes the diagnostic criteria for "Vestibular Migraine of Childhood", "probable Vestibular Migraine of Childhood" and "Recurrent Vertigo of Childhood" as put forth by the Committee for ...

The prevalence of psychiatric and chronic pain comorbidities in fibromyalgia: An acttion systematic review.

Jan 04, 2021

Fibromyalgia (FM) is a chronic widespread pain condition that overlaps with multiple comorbid health conditions and contributes to considerable patient distress. The aim of this review was to provide ...

Novel tankyrase inhibitors suppress TDP-43 aggregate formation.

Jan 04, 2021

Transactive response DNA-binding protein of 43 kDa (TDP-43) abnormally forms aggregates in certain subtypes of frontotemporal lobar degeneration (FTLD) and in amyotrophic lateral sclerosis (ALS). The...

Impact of a shelter-in-place order during the COVID-19 pandemic on the incidence of opioid overdoses.

Jan 04, 2021

Since the beginning of the novel coronavirus (COVID-19) pandemic in the United States, there have been concerns about the potential impact of the pandemic on persons with opioid use disorder. Shelter-...

Barriers and facilitators to PDMP IS Success in the US: A systematic review.

Jan 04, 2021

Prescription Drug Monitoring Programs (PDMP) help prevent prescription drug misuse and promote appropriate pain management. Despite these benefits and PDMP mandates in most states, PDMPs face challeng...

Type 1 helper T cells generate CXCL9/10-producing T-bet effector B cells potentially involved in the pathogenesis of rheumatoid arthritis.

Jan 04, 2021

Efficacy of B-cell depletion therapy highlights the antibody-independent effector functions of B cells in rheumatoid arthritis (RA). Given type 1 helper T (Th1) cells abundant in synovial fluid (SF) o...

How can neighborhood environments facilitate management of osteoarthritis: A scoping review.

Jan 04, 2021

The association between neighborhood environments and health outcomes has long been recognized, but the importance of environmental factors is less well examined in osteoarthritis (OA). We aimed to gi...

Association of interleukin-17 gene polymorphisms with the onset of Rheumatoid Arthritis.

Jan 04, 2021

Rheumatoid Arthritis (RA) is an autoimmune disorder where multiple cytokines including IL-17A and IL-17F produced by T helper cell 17 (Th17), contribute to its pathogenesis. By initiating inflammatory...

Application of the OMERACT synovitis ultrasound scoring system in juvenile idiopathic arthritis: a multicenter reliability exercise.

Dec 31, 2020

To evaluate the reliability of the OMERACT paediatric ultrasound (US) synovitis definitions and scoring system in JIA.Thirteen sonographers analysed 75 images for the presence/absence of elementary le...

Measuring complications of serious pediatric emergencies using ICD-10.

Dec 31, 2020

To create definitions for complications for 16 serious pediatric conditions using the International Classification of Diseases, 10th Revision, Clinical Modification or Procedure Coding System (ICD-10-...

Stepped Exercise Program for Patients With Knee Osteoarthritis : A Randomized Controlled Trial.

Dec 31, 2020

Evidence-based models are needed to deliver exercise-related services for knee osteoarthritis efficiently and according to patient needsTo examine a stepped exercise program for patients with knee ost...

Yishen-tongbi decoction inhibits excessive activation of B cells by activating the FcγRIIb/Lyn/SHP-1 pathway and attenuates the inflammatory response in CIA rats.

Dec 31, 2020

Rheumatoid arthritis (RA) is a chronic autoimmune disease. Strong evidence supports that excessive activation of B cells plays a critical role in the pathogenesis of RA. Fc gamma receptor b (FcγRIIb)...

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