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Pain General

Racial Disparities in Opioid Use and Lumbar Spine Surgery for Chronic Pain and in Pain and Function over Three Years: A Retrospective Cohort Study.

Oct 02, 2023

This study aims to compare treatments and outcomes among Black and White patients with chronic low back pain in the United States. A retrospective cohort study was conducted within a pain research reg...

Prognosis of patients with neuropathic low back-related leg pain: An exploratory study using prospective data from UK primary care.

Oct 02, 2023

This prospective cohort study investigates the prognosis of patients with neuropathic low back-related leg pain (LBLP) consulting in UK primary care. Data from 511 patients were collected using standa...

Patient Controlled Subcutaneous Analgesia of Hydromorphone Versus Morphine to Treat Moderate and Severe Cancer Pain: A Randomized Double-Blind Controlled Trial.

Sep 25, 2023

Hydromorphone and morphine are the common drugs used for the treatment of moderate to severe cancer pain. Patient controlled subcutaneous analgesia (PCSA) is an effective technique to manage cancer pa...

Traumatic Injuries and Radiographic Study Utilization Among Children with Drowning Presenting to U.S. Pediatric Hospitals.

Sep 25, 2023

The role of traumatic injuries in fatal and non-fatal drownings is poorly described. We sought to characterize the incidence of traumatic injuries and diagnostic imaging performed among children who r...

PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis.

Sep 25, 2023

Ankylosing spondylitis (AS) is a common inflammatory arthritis without a reliable biomarker. The role of methylation and mRNA expression of PRICKLE1 promoter in the pathogenesis of ankylosing spondyli...

"Buprenorphine, It Works so Differently": Adults with Sickle Cell Disease Describe Transitioning to Buprenorphine for Treatment of Chronic Pain.

Sep 25, 2023

A growing body of literature describes the use of buprenorphine for the treatment of chronic pain in people with sickle cell disease. The experiences of people with sickle cell disease who have tried ...

Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15-39 years from 1990 to 2019: findings from the global burden of disease study 2019.

Sep 18, 2023

In recent years, headache disorders have garnered significant attention as a pressing global health issue. This concern is especially pronounced in low- to middle-income countries and exhibits a notab...

Functional neurological seizures and migraine: A systematic review and case series.

Sep 18, 2023

The seizure subtype of functional neurological disorder (FND-seizures) is a common neuropsychiatric condition manifesting with episodic epilepsy-like events. Despite the common belief that FND-seizure...

A novel drug combination of Tofacitinib and Iguratimod alleviates rheumatoid arthritis and secondary osteoporosis.

Sep 18, 2023

The inadequate response of some patients with rheumatoid arthritis (RA) to current therapies is an issue that needs to be addressed. Patients with refractory RA (RRA) are often accompanied by high Tum...

Choice Enhances Placebo Hypoalgesia More in Weaker Placebo Contexts: A Partial Reinforcement Study.

Sep 18, 2023

Providing individuals with choice over treatment has been found to enhance placebo hypoalgesia. However, this choice effect is not always present. The current study tested whether the strength of the ...

Gout therapeutics and drug delivery.

Sep 11, 2023

Gout is a common inflammatory arthritis caused by persistently elevated uric acid levels. With the improvement of people's living standards, the consumption of processed food and the widespread use of...

Performance-related Pain Among Musicians Questionnaire (PPAM): multicenter validation of the first questionnaire to evaluate performance-related pain among musicians with different musical backgrounds.

Sep 11, 2023

We aim to present the first psychometric evaluation of the Performance-related Pain among Musicians Questionnaire (PPAM), the first questionnaire specifically designed to evaluate performance-related ...

Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder.

Sep 04, 2023

Opioid use disorder (OUD) is a chronic and relapsing brain disease that results in significant mortality worldwide. Genetic factors are estimated to contribute to 40%-60% of the liability, with polymo...

Ketamine metabolite alleviates morphine withdrawal-induced anxiety via modulating nucleus accumbens parvalbumin neurons in male mice.

Sep 04, 2023

Opioid withdrawal generates extremely unpleasant physical symptoms and negative affective states. A rapid relief of opioid withdrawal-induced anxiety has obvious clinical relevance but has been rarely...

Vitamin D supplementation for improving bone density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials.

Sep 04, 2023

Vitamin D supplements are widely used for improving bone health in children and adolescents, but their effects in vitamin D-deficient children are unclear.This study aimed to examine whether the effec...

Clinical Outcomes of Anatomic Versus Reverse Total Shoulder Arthroplasty in Primary Osteoarthritis with Preoperative External Rotation Weakness and an Intact Rotator Cuff: A Case-Control Study.

Sep 04, 2023

Anatomic and reverse total shoulder arthroplasty (aTSA, rTSA) are well-established treatments for patients with primary osteoarthritis and an intact cuff. However, it is unclear whether aTSA or rTSA p...

Pro-inflammatory Dietary Intake Relates to Pain Sensitivity in Chronic Non-Specific Low Back Pain: A Case-Control Study.

Sep 04, 2023

Non-specific chronic low back pain (nCLBP) has been associated with nutrition. Yet, it is not clear how nutritional factors and nCLBP relate to one another. Therefore, the aim of the present study was...

Associations between psychological stress and hand pain among rural and urban adults: Findings from the KoGES community cohort study.

Sep 04, 2023

Despite known health disparities in chronic pain conditions between rural and urban adults, few studies have examined whether longitudinal associations among psychological stress and hand pain differ ...

Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Center for Integrative Global Oral Health at the University of Pennsylvania.

Aug 28, 2023

A guideline panel convened by the American Dental Association Council on Scientific Affairs, American Dental Association Science and Research Institute, University of Pittsburgh School of Dental Medic...

Start RA treatment - Biologics or JAK-inhibitors?

Aug 28, 2023

Janus Kinase inhibitors (JAKis) have been approved for the treatment of Rheumatoid Arthritis (RA) for several years. They are the first oral advanced treatments with efficacy similar to, if not, great...

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