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Pain General

Pathogenic mechanisms of lipid mediator lysophosphatidic acid in chronic pain.

Dec 03, 2020

A number of membrane lipid-derived mediators play pivotal roles in the initiation, maintenance, and regulation of various types of acute and chronic pain. Acute pain, comprising nociceptive and inflam...

Dorsal Atlantoaxial Ligament Hypertrophy as a Cause for Clinical Signs in Dogs with Dens Abnormalities.

Dec 03, 2020

The objective of this study is to suggest clinical and subclinical atlantoaxial (AA) instability as a cause for dorsal AA ligament hypertrophy responsible for clinical signs in dogs with dens abnormal...

Treatment of Neck Pain with Opioids in the Primary Care Setting: Trends and Geographic Variation.

Dec 03, 2020

Neck pain is a leading cause of years lived with disability and is often managed with opioid medications in primary care settings, though this is contraindicated by national guidelines. The aim of thi...

Neuromonitoring in Cervical Spine Surgery: When Is a Signal Drop Clinically Significant?

Dec 03, 2020

Retrospective cohort study.To identify the clinical significance of different patterns of intraoperative neuromonitoring (IONM) signal alerts.IONM is a long-established valuable adjunct to complex spi...

Integrated Analysis of Gene Expression and Metabolite Data Reveals Candidate Molecular Markers in Colorectal Carcinoma.

Dec 03, 2020

This study was aimed to investigate the potential gene targets and metabolite markers associated with colorectal carcinoma (CRC). Gene expression data (GSE110224) related with CRC were obtained from...

Open-label placebo for chronic low back pain: a 5-year follow-up.

Dec 03, 2020

Long-term follow-up of patients treated with open-label placebo (OLP) are non-existent. Herein, we report a 5-year follow-up of a three-weeks OLP randomized controlled trial (RCT) in chronic low back ...

Enhancing analgesic spinal cord stimulation for chronic pain with personalized immersive virtual reality.

Dec 03, 2020

Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, sometimes requiring additi...

The sociocultural context of pediatric pain: an examination of the portrayal of pain in children's popular media.

Dec 03, 2020

Pain (eg, needle injections, injuries, and chronic pain) is highly prevalent in childhood and occurs in social contexts. Nevertheless, broader sociocultural influences on pediatric pain, such as popul...

Clinical features and outcomes from the Singapore Sjögren's syndrome study.

Dec 03, 2020

To study the clinical features, treatment and outcomes of primary Sjögren's Syndrome (pSS) in a Singapore cohort from an outpatient rheumatology clinic.Computerised Physician Order entry records of p...

Accelerated atherosclerosis in premenopausal women with rheumatoid arthritis - 15-year follow-up.

Dec 03, 2020

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased mortality and morbidity due to the higher cardiovascular risk in these patients. Traditional risk factors are not ...

High Prevalence of Perineural Cysts in Patients with Fibromyalgia and Chronic Fatigue Syndrome.

Dec 03, 2020

Pain in fibromyalgia (FM) and chronic fatigue syndrome (CFS) is assumed to originate from central sensitization. Perineural cysts or Tarlov cysts (TCs) are nerve root dilations resulting from patholog...

Trends in Academic Neurological Spine Surgeon Productivity as Measured by the Relative Citation Ratio (RCR).

Nov 30, 2020

The assessment of academic physicians should utilize field-independent publication metrics to measure improvement of grant outcomes, promotion, and continued evaluation of research productivity. Publi...

Does oblique lumbar interbody fusion promote adjacent degeneration in degenerative disc disease: A finite element analysis.

Nov 30, 2020

The number of oblique lumbar interbody fusion (OLIF) procedures has continued to rise over recent years. Adjacent segment degeneration (ASD) is a common complication following vertebral body fusion. A...

Yersinia enterocolitica: A Follow-up of the Outbreak in the Norwegian Armed Forces in 2014.

Nov 30, 2020

In the spring of 2014, there was an outbreak of Yersinia enterocolitica (YE) gastroenteritis in four Norwegian military camps-the largest outbreak ever reported in Norway. YE is usually transmitted vi...

G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain via the induction of Gβγ/ERK-mediated neuroinflammation in the trigeminal ganglion.

Nov 30, 2020

Trigeminal nerve injury-induced neuropathic pain is a debilitating chronic orofacial pain syndrome but lack of effective treatment. G protein-coupled receptors (GPCRs), especially orphan GPCRs (oGPCRs...

Brain imaging signature of neuropathic pain phenotypes in small-fiber neuropathy: altered thalamic connectome and its associations with skin nerve degeneration.

Nov 30, 2020

Small-fiber neuropathy (SFN) has been traditionally considered as a pure disorder of peripheral nervous system, characterized by neuropathic pain and degeneration of small-diameter nerve fibers in the...

Activation of Trace Amine-Associated Receptor 1 Selectively Attenuates the Reinforcing Effects of Morphine.

Nov 30, 2020

Trace amine-associated receptor 1 (TAAR1) plays a critical role in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TAAR1 mo...

Chronic Developmental Lead Exposure increases μ-Opiate Receptor Levels in the Adolescent Rat Brain.

Nov 30, 2020

Childhood lead (Pb) intoxication is a global public health problem best known for producing deficits in learning and poor school performance. Human and preclinical studies have suggested an associatio...

The HEALing (Helping to End Addiction Long-term ) Communities Study: Protocol for a cluster randomized trial at the community level to reduce opioid overdose deaths through implementation of an integrated set of evidence-based practices.

Nov 30, 2020

Opioid overdose deaths remain high in the U.S. Despite having effective interventions to prevent overdose deaths, there are numerous barriers that impede their adoption. The primary aim of the HEALing...

Effect of migraine attack on pupil size, accommodation and ocular aberrations.

Nov 30, 2020

To evaluate the pupil size, accommodation, and ocular higher-order aberrations (HOAs) in patients with migraine during migraine attacks and compare them with interictal period and healthy controls.Thi...

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