Oct 29, 2020

The only medication available currently to prevent and treat opioid overdose (naloxone) was approved by the Food and Drug Administration (FDA) nearly 50 years ago. Because of its pharmacokinetic and p...

Oct 29, 2020

The aim of this study is to compare postoperative outcomes and follow-up of two different modifications facilitating surgical technique of frozen elephant trunk (FET) procedure for complex thoracic ao...

Oct 29, 2020

Animal embryogenesis requires a precise coordination between morphogenesis and cell fate specification. During mesoderm induction, mesodermal fate acquisition is tightly coordinated with the morphogen...

Oct 29, 2020

Fibroblast-like synoviocytes (FLSs) are important non-immune cells located mostly in the inner layer of the synovium. Indeed, these cells are specialized mesenchymal cells, implicated in collagen home...

Oct 29, 2020

The objective was to evaluate the relationships between multimorbidity and overall fatigue as well as fatigue subdomains in patients with rheumatoid arthritis (RA).A cross-sectional study of a populat...

Oct 29, 2020

Studies in axial spondyloarthritis (AxSp) have shown that intensity of pain, anxiety, depression, and inflammatory activity are associated with poor sleep quality.To describe mood and sleep disorders ...

Oct 29, 2020

Preterm infants show a higher incidence of cognitive, social and behavioral problems, even in the absence of major medical complications during their stay in the neonatal intensive care unit (NICU). S...

Oct 29, 2020

Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without n...

Oct 29, 2020

Agonists to subtype C of the Mas-related G-protein-coupled receptors (MrgC) induce pain inhibition after intrathecal (i.t.) administration in rodent models of nerve injury. Here, we investigated wheth...

Oct 26, 2020

Multimodal pain management is the most effective way to treat postsurgical pain. However, the use of opioids for acute pain management has unfortunately been a significant contributor to the current...

Oct 26, 2020

Opioid use disorder (OUD) is characterized by heightened cognitive, physiological, and neural responses to opioid-related cues that are mediated by mesocorticolimbic brain pathways. Craving and withdr...

Oct 26, 2020

Complex regional pain syndrome (CRPS), formerly known as reflex sympathetic dystrophy (RSD), is a difficult to treat condition characterized by debilitating pain and limitations in functional ability....

Oct 26, 2020

In recent years, radiological and biochemical data has emerged regarding the development of cellular damage in the brain of patients with migraine, calling into question what has traditionally been ac...

Oct 26, 2020

Migraine is typically divided into 2 headache frequency denominated categories, episodic migraine (EM) and chronic migraine (CM). Characterizing more narrow headache day frequency groups may be of val...

Oct 26, 2020

Triptans, the most commonly prescribed acute treatments for migraine attacks are, per FDA labeling, contraindicated in cardiovascular (CV) disease patients and have warnings and precautions for those ...

Oct 26, 2020

Fibromyalgia (FM) is a chronic pain condition characterized by impaired emotional regulation. This study explored the brain response to pain-related fear as a potential brain signature of FM.We used a...

Oct 26, 2020

Current therapies for Juvenile Fibromyalgia (JFM), such as cognitive-behavioral therapy (CBT), improve pain coping but are less effective for pain reduction or engagement in physical activity. The Fib...

Oct 26, 2020

The phenotype of Spinal Muscular Atrophy (SMA) has been changing with the recent availability of three FDA-approved treatments: intrathecal Nusinersen, intravenous Onasemnogene abeparvovec-xioi and en...

Oct 26, 2020

Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine t...

Oct 26, 2020

The study of Patient-Controlled Analgesia (PCA) behaviors has led to greater understanding of factors that affect the pain experience. Although PCA behaviors can be influenced by cues to medication av...