Oct 12, 2020

In the present study we examined the potential association between age, gender, the genetic variant FKBP5 rs9470080 and subjective health complaints.The data were collected through a three-wave nation...

Oct 12, 2020

Opioids are the "gold standard" treatment for postoperative pain, but these drugs also have limiting adverse effects. Thus, adjuvant drugs might be useful in opioid therapy for postoperative pain. The...

Oct 12, 2020

Despite the growing recognition of acromial stress fractures (ASFs) following reverse total shoulder arthroplasty (RTSA), much of the current data is derived from single-center studies with limited ge...

Oct 12, 2020

As dysregulation of immunometabolism plays a key role in the immunological diseases, dyslipidemia frequently observed in rheumatoid arthritis (RA) patients (60%) is associated with the disease activit...

Oct 08, 2020

Opioid/heroin use is an epidemic in the United States (US). Polysubstance use dramatically increases risk of adverse overdose outcomes, versus use of a single substance. Co-use of heroin and cocaine, ...

Oct 08, 2020

Persons with opioid use disorder (OUD) often experience anhedonia and demoralization, yet there is relatively little research on the pathophysiology of anhedonia and demoralization in OUD treatment an...

Oct 08, 2020

Headaches are common complaints in children. The International Classification of Headache Disorders, 3 edition (beta version), defines more than 280 types of headaches. Primary headaches refer to inde...

Oct 08, 2020

In the "headache world," great attention has always been paid to migraine patients, especially for the research and development of new therapies. For the other forms of primary headaches, especially t...

Oct 08, 2020

To develop and internally validate a multivariable predictive model for days with new-onset migraine headaches based on patient self-prediction and exposure to common trigger factors.Accurate real-tim...

Oct 08, 2020

Fibromyalgia is a musculoskeletal disorder characterized by chronic, widespread muscle pain. This condition is associated with disturbed sleep, which has a direct impact on patient quality of life. Pa...

Oct 08, 2020

The trigeminal nerve complex is a very important and somewhat unique component of the nervous system. It is responsible for the sensory signals that arise from the most part of the face, mouth, nose, ...

Oct 08, 2020

Neuromyelitis optica spectrum disorder (NMOSD) is a type of central nervous system antibody-mediated disease which affects mainly optic nerves and spinal cord, but may also present with acute brainste...

Oct 08, 2020

Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis.Su...

Oct 08, 2020

This nationwide study aimed to compare use of oxycodone and doctor shopping for oxycodone in 2010 and 2016, and to quantify doctor shopping for oxycodone by sex, age, formulation, and dosage in 2010 a...

Oct 08, 2020

Little is known about risk factors for emergency department (ED) attendance for chronic pain (CP) management and the relative service burden. We examined emergency department (ED) utilisation in patie...

Oct 08, 2020

Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity and poorer response to treatment. Genetic factors acting in an age-specific ...

Oct 08, 2020

 The Rome IV criteria for primary chronic obstipation help to distinguish between short-term ailments and a chronic pattern of complaints 1. In general, there are several causes of defecation disord...

Oct 08, 2020

Herein, we describe the rapid synthesis of a focused library of trisubstituted imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines from 2,4-dichloro-3-nitropyridine using the combination of solution-p...

Oct 08, 2020

Androgen deprivation therapy (ADT) is a cornerstone of treatment for advanced prostate cancer (PCa); however, it accelerates the loss of bone mineral density (BMD), which increases fracture risk. Guid...

Oct 05, 2020

The opioid receptor (OPR) family comprises the mu-, delta-, and kappa-opioid, and nociceptin receptors that belong to the superfamily of 7-transmembrane spanning G protein-coupled receptors (GPCRs). T...