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Pain General

Suggestion Timing Moderates the Effects of Prior Pain Experiences on Pain Perception.

Jul 03, 2023

Two common elements in patient care are reoccurring painful events (e.g., blood draws) and verbal suggestions from others for lessened pain. Research shows that verbal suggestions for lower pain can d...

Successful Emergency Decompressive Laminectomy for Burkitt Lymphoma with Metastatic Spinal Lesions: A Case Report.

Jun 26, 2023

Although Burkitt lymphoma (BL) usually arises in the abdomen or pelvis, it can also arise in the epidural space as a primary or secondary site and present with back pain or limb weakness. Emergency ma...

[Effect of body mass index on short-term effectiveness of high tibial osteotomy in treatment of varus knee arthritis].

Jun 19, 2023

To investigate the effect of body mass index (BMI) on the short-term effectiveness of high tibial osteotomy (HTO) in the treatment of varus knee arthritis.The clinical data of 84 patients (84 knees) w...

Covariate adjustment in chronic pain trials: An oft-missed opportunity.

Jun 19, 2023

Self-reported pain intensity, frequently used as an outcome in randomized clinical trials (RCTs) of chronic pain, is often highly variable and could be associated with multiple baseline factors. Thus,...

Cluster-Randomized Comparative Effectiveness Trial of Physician-Directed Clinical Decision Support vs. Patient-Directed Education to Promote Appropriate Use of Opioids for Chronic Pain.

Jun 19, 2023

We compared the effectiveness of physician-directed clinical decision support (CDS) administered via electronic health record (EHR) vs. patient-directed education to promote appropriate use of opioids...

Estradiol administration increases anxiety-like behavior following chronic escalating morphine administration in hormone-replaced ovariectomized female rats.

Jun 12, 2023

Withdrawal from opioids can induce a state of anxiety and irritability. This negative state can facilitate continued drug taking, as the administration of opioids can alleviate unpleasant symptoms ass...

Understanding sedative effects within the context of acute Neuroinflammation in the developing brain: Potential induction of delirium-like behaviors.

Jun 12, 2023

Neurologic morbidity is highly prevalent in pediatric critical illness, and the use of benzodiazepines and/or opioids are risk factors for delirium and post-discharge sequelae. However, little is know...

Cervicogenic headache.

Jun 12, 2023

Cervicogenic headache, first proposed as a distinct headache in 1983, is a secondary headache to a primary cervical musculoskeletal disorder. Research into physical impairments was integral to clinica...

The Registry for Migraine (REFORM) study: methodology, demographics, and baseline clinical characteristics.

Jun 12, 2023

Erenumab has demonstrated effectiveness for prevention of migraine attacks, but the treatment is costly, and a considerable proportion of patients do not respond to it. The Registry for Migraine study...

How Does Meditation-Based Lifestyle Modification Affect Pain Intensity, Pain Self-Efficacy, and Quality of Life in Chronic Pain Patients? An Experimental Single-Case Study.

Jun 12, 2023

Chronic pain is a growing worldwide health problem and complementary and integrative therapy options are becoming increasingly important. Multi-component yoga interventions represent such an integrati...

Low Dose Naltrexone's Utility for Non-Cancer Centralized Pain Conditions - A Scoping Review.

Jun 12, 2023

At low doses, naltrexone (LDN) has been shown to modulate inflammation through the interruption of microglial cell activation within the central nervous system. One of the most likely contributors to ...

Causal association of rheumatoid arthritis with obstructive lung disease: Evidence from Mendelian randomization study.

Jun 12, 2023

Observational studies have found an association between rheumatoid arthritis (RA) and risk of obstructive lung disease (ORDs). However, whether RA plays a role in ORDs development remains unclear.This...

Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: Underlying mechanisms based on cell and molecular targets.

Jun 12, 2023

Inflammatory arthritis, primarily including rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, is a group of chronic inflammatory diseases, whose general feature is joint dysfunction wit...

Reductions in kinesiophobia and distress after pain neuroscience education and exercise lead to favourable outcomes: a secondary mediation analysis of a randomized controlled trial in primary care.

Jun 12, 2023

Pain neuroscience education combined with exercise (PNE + exercise) is an effective treatment for patients with chronic spinal pain. Yet, however, little is known about its underlying therapeutic mech...

Referred sensations in the orofacial region are associated with a decreased descending pain inhibition and modulated by remote noxious stimuli and local anesthesia.

Jun 12, 2023

Referred sensation (RS) as a specific clinical phenomenon has been known for a long time, although the underlying mechanisms remain unclear. The aims of this study were to assess if (1) healthy indivi...

Inequities in the treatment of opioid use disorder: A scoping review.

Jun 05, 2023

Given the lack of access to evidenced-based OUD treatment and the corresponding overdose crisis, researchers must evaluate and report health care inequities involving the treatment of OUD. Additionall...

Intra-articular injections of biological disease-modifying anti-rheumatic drugs in inflammatory arthropathies: an up-to-date narrative review.

Jun 05, 2023

Since the 1990s bDMARDs have revolutionized the treatment of chronic dysimmune inflammatory arthropathies such as Rheumatoid Arthritis, Psoriatic Arthritis and Axial Spondylarthritis. Nevertheless, de...

No Evidence that Working Memory Modulates the Plasticity of the Nociceptive System, as Measured by Secondary Mechanical Hypersensitivity.

Jun 05, 2023

The effect of cognition on the plasticity of the nociceptive system remains controversial. In this study, we examined whether working memory can buffer against the development of secondary hypersensit...

Modulation of thalamocingulate nociceptive transmission and glutamate secretion by targeting P2X7 receptor.

Jun 05, 2023

The complexity and diversity of pain signaling have led to obstacles for prominent treatments due to mechanisms that are not yet fully understood. Among adenosine triphosphate (ATP) receptors, P2X7 di...

Multimodal hypersensitivity derived from quantitative sensory testing predicts pelvic pain outcome: an observational cohort study.

May 29, 2023

Multimodal hypersensitivity (MMH)-greater sensitivity across multiple sensory modalities (eg, light, sound, temperature, pressure)-is associated with the development of chronic pain. However, previous...

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