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Pain General

Optimized acupuncture treatment (acupuncture and intradermal needling) for cervical spondylosis-related neck pain: a multicenter randomized controlled trial.

Sep 21, 2020

Cervical spondylosis (CS)-related neck pain is difficult to treat due to its degenerative nature. The aim of this nine-center, single-blinded, randomized controlled trial was to evaluate the efficacy ...

Neuropathic pain: clinical classification and assessment in patients with pain due to cancer.

Sep 21, 2020

Neuropathic cancer pain (NcP) is associated with worse treatment responses and specific therapy indications, but a standardized clinical diagnosis of NcP is still lacking.This is a prospective observa...

Safety and efficacy of galcanezumab in patients for whom previous migraine preventive medication from two to four categories had failed (CONQUER): a multicentre, randomised, double-blind, placebo-controlled, phase 3b trial.

Sep 21, 2020

Many patients who require migraine preventive treatment have not been able to tolerate or have not responded to multiple previous preventive medications. We aimed to assess the safety and efficacy of ...

MiR103a-3p and miR107 are related to adaptive coping in a cluster of fibromyalgia patients.

Sep 21, 2020

MicroRNA (miRNA) mainly inhibit post-transcriptional gene expression of specific targets and may modulate disease severity.We aimed to identify miRNA signatures distinguishing patient clusters with fi...

Comparison of patient-led, fibromyalgia-orientated physical activity and a non-specific, standardised 6-month physical activity program on quality of life in individuals with fibromyalgia: a protocol for a randomised controlled trial.

Sep 21, 2020

Exercise has been shown to significantly improve pain and function in individuals with fibromyalgia. Research into the effectiveness of exercise is often based on standardised exercise programmes that...

Fibromyalgia in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: prevalence and screening.

Sep 21, 2020

To explore the prevalence, clinical characteristics, and screening strategy for fibromyalgia (FM) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.A total of 3...

PF-06410293: An Adalimumab Biosimilar.

Sep 21, 2020

PF-06410293 (Amsparity/Abrilada) is a biosimilar of the anti-tumor necrosis factor (TNF)-α antibody adalimumab. It is approved for use in all indications for which adalimumab is approved, including i...

Pain Responses to Protease-Activated Receptor-2 Stimulation in the Spinal Cord of Naïve and Arthritic Rats.

Sep 21, 2020

There is strong evidence showing that the activation of peripheral proteinase-activated receptors type 2 (PAR-2) can initiate hyperalgesic and inflammatory responses in the joint. However, to date, th...

A risk score for postoperative nausea and/or vomiting in women undergoing cesarean delivery with intrathecal morphine.

Sep 21, 2020

Postoperative nausea/vomiting affects up to 80% of parturients undergoing cesarean delivery, but there is a lack of obstetric-specific risk-prediction models. We performed this study to identify posto...

A Multifaceted Approach to Opioid Education, Prescribing, and Disposal for Patients with Breast Cancer Undergoing Surgery.

Sep 17, 2020

Standardized prescribing practices are recommended to decrease opioid abuse, however, data regarding the handling and disposal of leftover narcotics are lacking. This quality improvement project and a...

Development and validation of a clinical prediction score for poor postoperative pain control following elective spine surgery.

Sep 17, 2020

Thirty percent to sixty-four percent of patients experience poorly controlled pain following spine surgery, leading to patient dissatisfaction and poor outcomes. Identification of at-risk patients bef...

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial.

Sep 17, 2020

Observational studies have shown a link between zinc deficiency and migraine headaches. We aimed to examine the effect of zinc supplementation on the characteristics of migraine attacks in patients wi...

Efficacy of patent foramen ovale closure for treating migraine: a prospective follow-up study.

Sep 17, 2020

This study aims to evaluate the potential of percutaneous patent foramen ovale (PFO) closure to improve the headache in patients with migraine and PFO, and discuss the difference between the randomize...

Validity and Intrarater Reliability Using a Smartphone Clinometer Application to Measure Active Cervical Range of Motion Including Rotation Measurements in Supine.

Sep 17, 2020

Technological advances have given smartphones the capabilities of sensitive clinical measurement equipment at lesser cost and higher availability. The Clinometer is a smartphone application that can b...

Association between FokI polymorphism of Vitamin D Receptor gene and lumbar spine disc degeneration: A systematic review and meta-analysis.

Sep 17, 2020

The aim of the present meta-analysis was to explore the association between FokI polymorphism of the VDR gene and lumbar spine disc degeneration.The search was performed in PubMed, Scopus and Web of S...

Effect of Perioperative Active Body Surface Warming Systems on Analgesic and Clinical Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Sep 17, 2020

Inadvertent perioperative hypothermia is a common complication of surgery, and active body surface warming (ABSW) systems are used to prevent adverse clinical outcomes. Prior data on certain outcomes ...

Effectiveness of Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial.

Sep 17, 2020

Current pharmacologic therapies for patients with osteoarthritis are suboptimal.To determine the efficacy of extract (CL) for reducing knee symptoms and effusion-synovitis in patients with symptomati...

Transcranial direct current stimulation accelerates the onset of exercise-induced hypoalgesia: a randomised controlled study.

Sep 17, 2020

Exercise-induced hypoalgesia (EIH) describes acute reductions in pain that occur following exercise. Current evidence suggests that the magnitude of EIH is small-to-moderate at best, warranting explor...

Changes in patient functioning and disability: results from a phase 3, double-blind, randomized, placebo-controlled clinical trial evaluating galcanezumab for chronic migraine prevention (REGAIN).

Sep 17, 2020

To evaluate secondary outcomes including changes in functioning and disability associated with galcanezumab, a humanized monoclonal antibody to calcitonin gene-related peptide, in patients with chroni...

Patient Perception of Depressive Symptoms in Rheumatic Diseases: A Cross-sectional Survey.

Sep 17, 2020

The presented study aimed to explore the presence and the self-identification of depressive symptoms among patients with rheumatic musculoskeletal diseases (RMDs) through the use of the Patient Health...

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