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Pain General

Maternal oxycodone treatment causes pathophysiological changes in the mouse placenta.

Sep 07, 2020

Pregnant women are increasingly being prescribed and abusing opioid drugs. As the primary communication organ between mother and conceptus, the placenta may be vulnerable to opioid effects but also ho...

Study on the pharmacodynamics and metabolomics of five medicinal species in Atractylodes DC. on rats with rheumatoid arthritis.

Sep 07, 2020

Atractylodes DC. mainly includes Atractylodis Rhizoma and Atractylodis macrocephalae Rhizoma. According to Chinese Pharmacopoeia, Atractylodis Rhizoma is the rhizome of Atractylodes lancea (Thunb.) DC...

Risk Factors for Increased Postoperative Pain and Recommended Order Set for Postoperative Analgesic Usage.

Sep 07, 2020

An interdisciplinary pain team (IPT) was established at our institution to explore options for improving pain control in patients undergoing orthopaedic surgery by identifying traits that put a patien...

Visuomotor impairments in Complex Regional Pain Syndrome during pointing tasks.

Sep 07, 2020

Complex Regional Pain Syndrome (CRPS) is thought to be characterized by cognitive deficits affecting patients' ability to represent, perceive and use their affected limb as well as its surrounding spa...

Intergenerational transmission of chronic pain-related disability: the explanatory effects of depressive symptoms.

Sep 07, 2020

Parents with chronic pain have a higher likelihood of having depression and anxiety and more often have children with these conditions. Depressive and anxious symptoms in children worsen pain-related ...

Passive stiffness characteristics and neutral zone quality of the scoliotic lumbar torso in the principle anatomical planes of motion.

Sep 07, 2020

The 1-10% prevalence rate of adult scoliosis frequently requires expensive therapy and surgical treatments and demands further research into the disease, especially with an aging population. Most stud...

Symptoms and Clinical Findings in Primary Headache Syndrome Versus Chronic Rhinosinusitis.

Sep 07, 2020

Primary headache syndrome (PHS) patients frequently present to otolaryngologists with sinonasal complaints and diagnosis of chronic rhinosinusitis (CRS) due to symptomatic overlap. In this study, we c...

Acupuncture versus Various Control Treatments in the Treatment of Migraine: A Review of Randomized Controlled Trials from the Past 10 Years.

Sep 07, 2020

Migraine is defined as a recurrent headache of moderate to severe intensity that seriously affects the quality of life. Recent clinical trials have confirmed that acupuncture is effective in treating ...

Evaluating the effect of syrup on being migraine-free using mixture models.

Sep 07, 2020

(coriander) is prescribed as a treatment for headache in traditional Persian medicine. Several investigations have been carried out to find the medicinal properties of this plant. However, no study h...

Risk of hearing loss in patients with fibromyalgia: A nationwide population-based retrospective cohort study.

Sep 07, 2020

Our objectives are to examine whether patients with fibromyalgia (FM) present an increased risk of hearing loss (HL) compared with those without FM and to explore the relationship between comorbiditie...

Efficacy of pregabalin as a monotherapy versus combined pregabalin and milnacipran in the management of fibromyalgia.

Sep 07, 2020

To compare the efficacy and tolerability of combined pregabalin (PGB) and milnacipran (MLN) in female patients with fibromyalgia (FM) versus PGB as a monotherapy.The present randomized open study incl...

A feasibility randomised controlled trial of a fibromyalgia self-management programme in a community setting with a nested qualitative study (FALCON): Study protocol.

Sep 07, 2020

Fibromyalgia (FM) is a complex long-term condition associated with chronic widespread pain, fatigue, sleep problems, memory and concentration difficulties and irritable bowel syndrome. Current guideli...

Pentraxin 3 inhibits fibroblast growth factor 2 induced osteoclastogenesis in rheumatoid arthritis.

Sep 07, 2020

Synovial fibroblasts (SFs) act as key effector cells mediating synovial inflammation and joint destruction in rheumatoid arthritis (RA). Fibroblast growth factor 2 (FGF2) and its receptors (FGFRs) pla...

Evaluation of anti rheumatic activity of Piper betle L. (Betelvine) extract using in silico, in vitro and in vivo approaches.

Sep 07, 2020

Rheumatoid Arthritis is a chronic, inflammatory, and systemic autoimmune disease, it affects elders worldwide. Herbal medicines have been used for the treatment of various ailments from ancient times....

Thienorphine induces antinociception without dependence through activation of κ- and δ-, and partial activation of μ- opioid receptor.

Sep 03, 2020

Thienorphine hydrochloride is a new anti-relapse drug for opioid abusers that is currently in phase II clinical trial. In the present study, the antinociception, dependence, and signal transduction in...

Review of addiction risk potential associated with adolescent opioid use.

Sep 03, 2020

Adolescence is a critical period of development with robust behavioral, morphological, hormonal, and neurochemical changes including changes in brain regions implicated in the reinforcing effects of d...

Postoperative Opioid Utilization Associated with Revision Risk Following Primary Shoulder Arthroplasty.

Sep 03, 2020

With a substantial increase in utilization of primary shoulder arthroplasty, it is important to understand risk factors that may signal early failure and need for revision. Recent studies have reporte...

Predicting the outcome of the greater occipital nerve block - an observational study on migraine patients with and without musculoskeletal cervical impairment.

Sep 03, 2020

The importance of neck pain and the trigeminocervical complex in migraine is of high pathophysiological interest since a block to the greater occipital nerve is more effective for some primary headach...

Reason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: A nested cohort study.

Sep 03, 2020

Posttraumatic headache is difficult to define and there is debate about the specificity of the 7-day headache onset criterion in the current definition. There is limited evidence available to guide de...

Implications of Transient Receptor Potential Cation Channels in Migraine Pathophysiology.

Sep 03, 2020

Migraine is a common and debilitating headache disorder. Although its pathogenesis remains elusive, abnormal trigeminal and central nervous system activity is likely to play an important role. Transie...

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