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Pain General

Monoclonal antibodies against calcitonin gene-related peptide in chronic migraine: an adjusted indirect treatment comparison.

Aug 31, 2020

New monoclonal antibodies against the calcitonin generelated peptide pathway have recently been developed for the  prevention of migraine. The aim of this study is to compare the efficacy  of mono...

Longitudinal Impact of Parent Factors in Adolescents With Migraine and Tension-Type Headache.

Aug 31, 2020

To examine longitudinal associations between parent factors (parent headache frequency and disability, protective parenting behaviors, parent catastrophizing) with adolescent headache-related disabili...

Implementation of an Intravenous Dihydroergotamine Protocol for Refractory Migraine in Children.

Aug 31, 2020

Retrospective chart review to assess the effectiveness of an institutional intravenous (IV) dihydroergotamine (DHE) therapy protocol for refractory migraine in the pediatric population.Limited high-qu...

Patients with fibromyalgia show increased beta connectivity across distant networks and microstates alterations in resting-state electroencephalogram.

Aug 31, 2020

Fibromyalgia (FM) is a chronic condition characterized by widespread pain of unknown etiology associated with alterations in the central nervous system. Although previous studies demonstrated altered ...

Pharmacokinetics of Ampreloxetine, a Norepinephrine Reuptake Inhibitor, in Healthy Subjects and Adults with Attention-Deficit/Hyperactive Disorder or Fibromyalgia Pain.

Aug 31, 2020

Ampreloxetine is a novel norepinephrine reuptake inhibitor in development for the treatment of symptomatic neurogenic orthostatic hypotension. The objectives of this analysis were to define the pharma...

Polymorphisms of brain-derived neurotrophic factor genes are associated with anxiety and body mass index in fibromyalgia syndrome patients.

Aug 31, 2020

Fibromyalgia syndrome has been associated with familial clusters although the specific genetic predisposition is not clear. Accordingly, studies concerning genetic factors associated with this disease...

Measurement of minimal disease activity in psoriatic arthritis using PROMIS-Physical Function or the Health Assessment Questionnaire-Disability Index.

Aug 31, 2020

To assess the interchangeability of the Health Assessment Questionnaire-Disability Index (HAQ-DI) with the Patient-Reported Outcomes Measurement Information System-Physical Function (PROMIS-PF) in the...

A Closer Look at Patterns in Prescription Opioid Use & Misuse Among Cancer Survivors

Aug 28, 2020

Recent reports have shown that about one-third of cancer survivors experience cancer-related pain, and prescription rates for opioids are higher for these patients than the general population. The Ame...

A Population Study of Prescribed Opioid-based Pain Reliever Use among Individuals with Mood and Anxiety Disorders in Canada.

Aug 27, 2020

In the context of the ongoing North American overdose crisis, a clear understanding of opioid prescription and usage trends is important. Although individuals with mood and/or anxiety disorders are a ...

Efficacy of an Enhanced Recovery After Surgery (ERAS) Pathway in Elderly Patients Undergoing Spine and Peripheral Nerve Surgery.

Aug 27, 2020

Elderly patients are a vulnerable patient population in elective spinal surgery. Older patients have more medical comorbidities and are also more sensitive to opiate medications. Despite this, spine a...

Treatment-Refractory Headache in the Setting of COVID-19 Pneumonia: Migraine or Meningoencephalitis? Case Report.

Aug 27, 2020

The coronavirus responsible for the COVID-19 pandemic, SARS-2-CoV, most commonly involves the respiratory tract; however, more severe cases have been found to have multi-organ involvement, including t...

A Review on the Potential Receptors of Migraine with a Special Emphasis on Cgrp to Develop an Ideal Antimigraine Drug.

Aug 27, 2020

Background and Objective: Migraine is a neurovascular syndrome associated with unilateral, throbbing headache accompanied with nausea, vomiting and photo/phonophobia. Several proteins are involved in ...

Relative Cost Differences of Initial Treatment Strategies for Newly Diagnosed Opioid Use Disorder: A Cohort Study.

Aug 27, 2020

Relative costs of care among treatment options for opioid use disorder (OUD) are unknown.We identified a cohort of 40,885 individuals with a new diagnosis of OUD in a large national de-identified clai...

Low bone mass and hypovitaminosis D in haemophilia: A single-centre study in patients with severe and moderate haemophilia A and B.

Aug 27, 2020

Haemophilia (H) is frequently associated with a multifactorial reduction in bone mineral density (BDM), but little is known about possible differences between HA and HB according to their severity.To ...

Bleeding complications during pregnancy and delivery in haemophilia carriers and their neonates in Western France: An observational study.

Aug 27, 2020

Pregnancy, delivery and the postpartum period expose haemophilia carriers, as well as their potentially affected neonates to a high risk of haemorrhagic complications.To describe bleeding complication...

Flourensia fiebrigii S.F. Blake: A medicinal plant from the Argentinean highlands with potential use as anti-rheumatic and anti-inflammatory.

Aug 27, 2020

Flourensia fiebrigii is a plant used in traditional medicine in the Argentine Calchaquí Valley as purgative, expectorant, anti-rheumatic and anti-inflammatory.The aim of this study was to analyze the...

Criteria Used for the Diagnosis of Myofascial Trigger Points in Clinical Trials on Physical Therapy: Updated Systematic Review.

Aug 27, 2020

To conduct an updated systematic review of diagnostic criteria for myofascial trigger points (MTrPs) used in clinical trials of physical therapy interventions from 2007 to 2019.MEDLINE and Physiothera...

Longitudinal Patterns of Pain Reporting among Community-dwelling Older Adults.

Aug 27, 2020

To identify and describe long-term trajectories of bothersome pain and activity-limiting pain in a population-based sample of older adults.We conducted a retrospective cohort study of 6783 community-d...

Placebo Response Reduction and Accurate Pain Reporting Training Reduces Placebo Responses in a Clinical Trial on Chronic Low Back Pain: Results from a Comparison to the Literature.

Aug 27, 2020

A literature review was conducted to compare placebo responses in a recent trial-which implemented an Accurate Pain Reporting (APR) and Placebo Response Reduction (PRR) training program-to placebo res...

Attentional bias to somatosensory stimuli in chronic pain patients: a systematic review and meta-analysis.

Aug 27, 2020

This systematic review and meta-analysis aimed to evaluate the evidence pertaining to attentional bias for painful and non-painful somatosensory stimuli in individuals with chronic pain. Eligible stud...

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