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Pain General

[Analysis of clinical features of vestibular migraine].

Aug 27, 2020

To analyze the clinical features of Vestibular migraine(VM) and provide evidence for its accurate diagnosis and medical identification of flight personnel. A total of 490 samples of VM patients we...

Alternative therapy of rheumatoid arthritis with a novel transdermal patch containing Siegesbeckiae Herba extract.

Aug 27, 2020

Siegesbeckiae Herba (SiH) is a traditional anti-rheumatic herbal medicine in China. A SiH derived product, Phynova Joint and Muscle Relief Tablets™, has been granted the UK license in 2015. Alt...

Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice.

Aug 27, 2020

Liriodendron chinense (Hemsl.) Sarg, known as the Chinese tulip tree, has a long history of cultivation and utilization in many Asia countries, especially in China to use in traditional Chinese medici...

Treating Fibromyalgia Pain With Lidocaine

Aug 26, 2020

Previous studies indicate that chronic pain, including fibromyalgia (FM), negatively impacts quality of life (QoL) for the reportedly affected 3%-6% of the world population. “There is supportive evi...

Emerging regulatory roles of opioid peptides, endogenous morphine, and opioid receptor subtypes in immunomodulatory processes: Metabolic, behavioral, and evolutionary perspectives.

Aug 24, 2020

Integrated behavioral paradigms such as nociceptive processing coupled to anti-nociceptive responsiveness include systemically-mediated states of alertness, vigilance, motivation, and avoidance. Withi...

Psychological factors associated with substance use initiation during the COVID-19 pandemic.

Aug 24, 2020

The 2019 outbreak of the novel coronavirus (COVID-19) has had a devastating impact. Given the on-going nature of the outbreak, the deleterious toll on mental health, including substance use, is unknow...

Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods: MScanFit MUNE and muscle velocity recovery cycles.

Aug 24, 2020

To examine the peripheral nervous system (PNS) in spinal cord injured (SCI) patients using two novel methods: (1) MScanFit MUNE; a motor unit number estimation method detecting motor unit loss and (2)...

Nano wet milled celecoxib extended release microparticles for local management of chronic inflammation.

Aug 24, 2020

Osteoarthritis (OA), the most common form of arthritis, is characterized by chronic inflammation, degeneration of articular cartilage and whole joints. Local delivery by intra-articular (IA) injection...

A spider-venom peptide with multi-target activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome.

Aug 24, 2020

Chronic pain is a serious debilitating condition that affects ∼20% of the world's population. Currently available drugs fail to produce effective pain relief in many patients and have dose-limiting ...

The use and reporting of neonatal pain scales: a systematic review of randomized trials.

Aug 24, 2020

The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infan...

Nociceptive afferent phenotyping reveals that TRPA1 promotes cold pain via neurogenic inflammation upstream of the neurotrophic factor receptor GFRα3 and the menthol receptor TRPM8.

Aug 24, 2020

The proper detection and behavioral response to painfully cold temperatures is critical for avoiding potentially harmful tissue damage. Cold allodynia and hyperalgesia, pain associated with innocuous ...

Machine learning-based automated classification of headache disorders using patient-reported questionnaires.

Aug 24, 2020

Classification of headache disorders is dependent on a subjective self-report from patients and its interpretation by physicians. We aimed to apply objective data-driven machine learning approaches to...

A Paradoxical Vasodilatory Nutraceutical Intervention for Prevention and Attenuation of Migraine-A Hypothetical Review.

Aug 24, 2020

Studies suggest that migraine pain has a vascular component. The prevailing dogma is that peripheral vasoconstriction activates baroreceptors in central, large arteries. Dilatation of central vessels ...

MRI in migraineurs: are there abnormalities in the area where the myofascial trigger points are palpable and in volume measurements?

Aug 24, 2020

Patients with migraine may present a higher quantity of myofascial trigger points (MTrP) and alterations in the cervical muscles when compared to non-migraineurs. The magnetic resonance imaging (MRI) ...

Is there a dose response relationship between soft tissue manual therapy and clinical outcomes in fibromyalgia?

Aug 24, 2020

Current clinical guidelines do not support the use of manual therapy (MT) interventions for Fibromyalgia (FM) patients, despite evidence of positive biochemical, mechanical and psychological effects, ...

Impaired Cardiac Autonomic Control in Women With Fibromyalgia Is Independent of Their Physical Fitness.

Aug 24, 2020

Evidence has suggested abnormal cardiac autonomic responses to exercise in patients with fibromyalgia (FM). However, it is not clear whether the dysautonomia represents a reduced physical fitness rath...

Effects of Brief Guided Imagery on Female Patients Diagnosed with Fibromyalgia: An Exploratory Controlled Trial.

Aug 24, 2020

To evaluate the effect of Brief Guided Imagery (BGI) on patients suffering chronic, fibromyalgia-related pain.Fibromyalgia is characterized by chronic pain and accompanied by fatigue, depression, slee...

Restless legs syndrome in children and adolescents with attention-deficit/hyperactivity disorder: prevalence, mimic conditions, risk factors, and association with functional impairment.

Aug 24, 2020

To determine the prevalence of restless legs syndrome (RLS) and RLS-mimic conditions, the risk factors for RLS, and whether RLS contributes to functional impairment in children and adolescents with at...

Comprehensive analysis of multiple cytokines and blood parameters for the diagnosis of bacterial infections in rheumatoid arthritis.

Aug 24, 2020

Patients with rheumatoid arthritis (RA) are more susceptible to infections, which elevate the levels of relative cytokines. However, the ability of the cytokines levels to predicate bacterial infectio...

Heme attenuates beta-endorphin levels in leukocytes of HIV positive individuals with chronic widespread pain.

Aug 24, 2020

The prevalence of chronic widespread pain (CWP) in people with HIV is high, yet the underlying mechanisms are elusive. Leukocytes synthesize the endogenous opioid, β-endorphin, within their endoplasm...

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