Aug 21, 2020

A multimodal approach is most often necessary to adequately manage chronic nonspecific neck pain and low back pain (LBP). The treatment plan may include medications with differing sites of action, phy...

Aug 20, 2020

Many diabetic individuals use prescription and non-prescription opioids and opiates. We aimed to investigate the joint effect of diabetes and opiate use on all-cause and cause-specific mortality.Goles...

Aug 20, 2020

Cannabinoids, cannabis, and cannabis-based medicines (CBMs) are increasingly used to manage pain, with limited understanding of their efficacy and safety. We summarised efficacy and adverse events (AE...

Aug 20, 2020

The American College of Physicians (ACP) and American Academy of Family Physicians (AAFP) developed this guideline to provide clinical recommendations on nonpharmacologic and pharmacologic management ...

Aug 20, 2020

Patients and clinicians can choose from several treatment options to address acute pain from non-low back musculoskeletal injuries.To assess the comparative effectiveness of outpatient treatments for ...

Aug 20, 2020

Most people with opioid use disorder (OUD) are not treated with FDA-approved medications methadone, buprenorphine, or naltrexone. Expanding capacity for evidence-based OUD medication in primary care i...

Aug 20, 2020

The trigemino-vascular system (TVS) plays a key role in migraine pathophysiology. Glial cells are abundant in the TVS system and mainly in the trigeminal ganglion. S100B protein is a calcium-binding p...

Aug 20, 2020

Administration of ATP-sensitive potassium channel opener levcromakalim triggers headache in healthy volunteers and migraine attacks in migraine patients. Here, we investigated the effect of ATP-sensit...

Aug 20, 2020

Medication overuse headache is estimated to affect 2% of the population, and is ranked in the top 20 most disabling disorders due to its high level of disability. Several therapies used in the treatme...

Aug 20, 2020

Chronic pain is commonly associated with anxiety and depression, making it more challenging to be managed. Psychological interventions are suggested for such complicated issues which are well evident...

Aug 20, 2020

Individuals with hypermobility spectrum disorders/hypermobile Ehlers-Danlos syndrome (HSD/hEDS) frequently fulfill criteria for Rome IV functional gastrointestinal disorders (FGIDs). Postural orthosta...

Aug 20, 2020

The aim of this study was to evaluate the impact of comorbidities on disease activity, patient's impact of the disease, patient global assessment, and function in psoriatic arthritis (PsA).Consecutive...

Aug 20, 2020

As well-known medicinal materials in traditional Chinese medicine, scorpions, commonly called as Quanxie () in Chinese, have been widely used to treat several diseases such as rheumatoid arthritis, ap...

Aug 20, 2020

CD83, either in its membrance-bound form (mCD83) or soluble form (sCD83), is an important immunomodulatory molecule in humans and mice. While mCD83 is immunostimulatory, sCD83 exhibits striking immuno...

Aug 20, 2020

MicroRNAs (miRNAs) are single-strand endogenous and non-coding RNA molecules with a length of about 22 nucleotides, which regulate genes expression, through modulating the translation and stability of...

Aug 19, 2020

“There has been very little practical guidance on how to consistently implement reductions in prescribed doses, how to safely taper opioids after surgery, and how to personalize opioid prescribing t...

Aug 17, 2020

Patients hospitalised with COVID-19 have increased morbidity and mortality, which requires extensive involvement of specialist Hospital Palliative Care Teams. Evaluating the response to the surge in d...

Aug 17, 2020

Osseous-associated cervical spondylomyelopathy (OA-CSM) is a complex disorder with limited long-term survival. The longitudinal progression is currently unknown.To describe changes on magnetic resonan...

Aug 17, 2020

Interstitial lung disease (ILD) accounts for the major cause of morbidity and mortality in rheumatoid arthritis (RA). However, little is known of the pathogenesis, diagnosis and treatment of RA-associ...

Aug 17, 2020

A vaccine against coronavirus disease 2019 (COVID-19) is urgently needed.To evaluate the safety and immunogenicity of an investigational inactivated whole-virus COVID-19 vaccine in China.In the phase ...