Jun 12, 2023

Pain neuroscience education combined with exercise (PNE + exercise) is an effective treatment for patients with chronic spinal pain. Yet, however, little is known about its underlying therapeutic mech...

Jun 12, 2023

Referred sensation (RS) as a specific clinical phenomenon has been known for a long time, although the underlying mechanisms remain unclear. The aims of this study were to assess if (1) healthy indivi...

Jun 05, 2023

Given the lack of access to evidenced-based OUD treatment and the corresponding overdose crisis, researchers must evaluate and report health care inequities involving the treatment of OUD. Additionall...

Jun 05, 2023

Since the 1990s bDMARDs have revolutionized the treatment of chronic dysimmune inflammatory arthropathies such as Rheumatoid Arthritis, Psoriatic Arthritis and Axial Spondylarthritis. Nevertheless, de...

Jun 05, 2023

The effect of cognition on the plasticity of the nociceptive system remains controversial. In this study, we examined whether working memory can buffer against the development of secondary hypersensit...

Jun 05, 2023

The complexity and diversity of pain signaling have led to obstacles for prominent treatments due to mechanisms that are not yet fully understood. Among adenosine triphosphate (ATP) receptors, P2X7 di...

May 29, 2023

Multimodal hypersensitivity (MMH)-greater sensitivity across multiple sensory modalities (eg, light, sound, temperature, pressure)-is associated with the development of chronic pain. However, previous...

May 29, 2023

Pain radiating from the spine into the leg is commonly referred to as "sciatica," "Sciatica" may include various conditions such as radicular pain or painful radiculopathy. It may be associated with s...

May 22, 2023

Polyarthritis is commonly reported in idiopathic inflammatory myositis patients, but few studies have focused on the overlap of myositis with rheumatoid arthritis which is a difficult diagnosis in the...

May 22, 2023

While a range of work-related psychosocial factors have been associated with various pain disorders and early retirement, less is known about pain cognitions and their influence on premature exit from...

May 22, 2023

We aimed to determine whether adipokines are associated with pain and polysymptomatic distress in patients with rheumatoid arthritis (RA) over time in a large patient registry. The cohort study was co...

May 15, 2023

To predict behavioral disruptions in middle childhood, we identified latent classes of prenatal substance use.As part of the Environmental influences on Child Health Outcomes (ECHO) Program, we harmon...

May 15, 2023

DNA methylation is one of the epigenetic mechanisms involved in opioid use disorder. GAD2 is a key catalyticase in gamma amino butyric acid (GABA) synthesis from glutamate, that is implicated in opioi...

May 15, 2023

Retrospective cohort study.To compare the relative value units (RVUs) per minute of operative time between primary and revision surgery for adult spinal deformity (ASD).Surgery for ASD is technically ...

May 15, 2023

The timing of the switch from intravenous (IV) to oral antibiotic therapy for orthopaedic bone and joint infections (BJI) is debated. In this narrative article, we discuss the evidence for and against...

May 15, 2023

Inflammation plays pivotal role in the development of chronic diseases. Reducing chronic inflammation is an important strategy for preventing and managing many chronic diseases. In traditional Chinese...

May 15, 2023

Shoulder pain is a highly prevalent musculoskeletal condition that frequently leads to suboptimal clinical outcomes. This study tested the extent to which circulating inflammatory biomarkers are assoc...

May 08, 2023

Oxytocin is routinely administered after delivery for prophylaxis and treatment of postpartum hemorrhage, but it is associated with considerable cardiovascular side-effects. Carbetocin, a synthetic ox...

May 08, 2023

Overweight and/or obese patients with inflammatory arthritis (IA) have higher disease activity and lower chances of achieving and/or maintaining the treatment targets. Weight/obesity also appears to n...

May 08, 2023

Chronic pain is a multidimensional experience and pain treatments targeting psychosocial factors reduce pain and improve function. These treatments often overlook the sociocultural factors that influe...